The Philadelphia Eagles will look to defend their Lombardi Trophy later today as they open the postseason against the San Francisco 49ers.
Kickoff is set for 4:30 p.m. ET from Lincoln Financial Field, and we have you covered for this Wild Card Weekend showdown with our best 49ers vs. Eagles predictions for Sunday, January 11.
49ers vs Eagles SNF predictions
- Eagles -5 (-115 at FanDuel)
- Goedert anytime touchdown (+190 at FanDuel)
- Purdy Over 0.5 interceptions (-146 at FanDuel)
49ers vs Eagles SNF best bets
Eagles -5
Led by their stop-unit, Rohit Ponnaiya expects the defending champs to stand tall at home.
"San Francisco's offense was held to three points and 173 yards in their season finale and now travels across the country to face an elite Philadelphia Eagles defense. Philly rested many of its starters last week and ranked second in the NFL in defensive success rate between Weeks 8 and 17."
49ers vs Eagles SNF TD picks
Dallas Goedert anytime touchdown
Sam Farley is bullish on tight end Dallas Goedert exploiting the 49ers’ linebackers in coverage.
"This bet is both a wager on Dallas Goedert and a lack of confidence in the 49ers' ability to defend tight ends efficiently. Goedert missed Week 18 with an injury but scored in his three games before that, and he leads both AJ Brown and DeVonta Smith in red-zone targets this season."
49ers vs Eagles SNF props
Brock Purdy Over 0.5 interceptions
Jeremy Jones sees a turnover looming for Brock Purdy at the Linc.
"Purdy threw nine of his 10 total interceptions when targeting in-breaking routes this season. The Eagles’ defense allowed a league-low 51.9% completion rate on those routes, the lowest rate surrendered by any defense in a single season since 2016."
49ers vs Eagles odds
49ers vs Eagles game info
| Location: | Lincoln Financial Field, Philadelphia, PA |
| Date: | Sunday, January 11, 2026 |
| Kickoff: | 4:30 p.m. ET |
| TV: | FOX |
49ers vs Eagles latest injuries
49ers vs Eagles weather
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