This week's college football against-the-spread picks are headlined by two big-time matchups: No. 1 Ohio State taking on No. 4 Texas in Austin, and No. 11 Oklahoma heading to The Big House to take on Michigan following a controversial Wolverines win in Week 1.
My college football picks also cast some doubt on Keelon Russell as he makes his first big road start against Kentucky. Check out my full card of picks below.
College football picks against the spread for Week 2
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| Matchup |  |
|---|---|
 Missouri vs  Kansas |
+5.5 |
 Oregon vs  Oklahoma State |
-22.5 |
 Oklahoma vs  Michigan |
-5.5 |
 Alabama vs  Kentucky |
+10.5 |
 Tennessee vs  Georgia Tech |
+12.5 |
 Ohio State vs  Texas |
-1.5 |
 Iowa State vs  Iowa |
-13.5 |
Percentages courtesy of Kalshi, one of the best prediction market apps.
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Expert Week 2 CFB ATS picks
Missouri (-5.5) vs Kansas: Kansas +5.5
With Mizzou missing its biggest weapon in Ahmad Hardy, the gap between these teams is slim to none. With Kansas at home, I'll take the points with the Jayhawks.
Oregon (-22.5) vs Oklahoma State: Oregon -22.5
I expect to see an angry Oregon team on Saturday after hanging on by a thread in the season opener against Boise State. The offense found its rhythm in the second half of that game, and Dan Lanning will want to see a full 60 minutes of that here.
Oklahoma (-5.5) vs Michigan: Oklahoma -5.5
I can't possibly back Michigan after how shaky the Wolverines offense looked in Week 1. That won't fly against what I think is a real sleeper in the SEC. Lay the number with OU on the road.
Alabama (-10.5) vs Kentucky: Kentucky +10.5
This is a battle of two first-time starting quarterbacks, but it's more of an ask for Keelon Russell to cover a double-digit spread in his first SEC road test. If both teams look to keep it on the ground, this game will stay within reach.
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Tennessee (-12.5) vs Georgia Tech: Georgia Tech +12.5
Not dissimilar to Keelon Russell, this will be Tennessee freshman quarterback Faizon Brandon's first true test, and it's coming on the road. Throw in the double-digit spread, and I'm happy to lean the other way in a big bounce-back spot for the Yellow Jackets.
Ohio State vs Texas (-1.5): Texas -1.5
Ohio State's shaky offensive line against this Colin Simmons-led Texas front is the matchup I think will ultimately be the reason the Longhorns win, and the Buckeyes lack the disruptive playmakers they had in last year's win to make up for it on the other side.
Iowa State vs Iowa (-13.5): Iowa -13.5
These teams are heading in opposite directions. Iowa State is dealing with major turnover in Matt Campbell's absence, while Iowa looks ready to potentially threaten the top of the Big Ten. That gap will be on display in this game.
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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