College Football Picks Against the Spread for Week 14

Our Rivalry Week college football picks target Ohio State against Michigan, Oregon against Washington, and Texas A&M over Texas.

Chris Gregory - Betting Analyst at Covers.com
Chris Gregory • Betting Analyst
Nov 25, 2025 • 15:50 ET • 4 min read
Ryan Day Ohio State Buckeyes Big Ten college football
Photo By - Imagn Images. Ryan Day during Ohio State's last game against Rutgers.

Rivalry Week is one of the best weeks on the college football calendar, featuring historic matchups dating back more than 100 years.

The biggest of them all is The Game between No. 1 Ohio State and No. 15 Michigan. The Wolverines have won the matchup in four straight years and get this year's edition in Ann Arbor.

I pick a side in my Week 14 ATS college football picks below.

College football picks against the spread for Week 14

Matchup Pick
Mississippi Mississippi vs Mississippi State Mississippi State Mississippi State (+7.5)
Iowa Iowa vs Nebraska Nebraska Iowa (-6.5)
Georgia Georgia vs Georgia Tech Georgia Tech Georgia Tech (+13.5)
Texas A&M Texas A&M vs Texas Texas Texas A&M (-2.5)
Miami Miami vs Pittsburgh Pittsburgh Pittsburgh (+6.5)
Ohio State Ohio State vs Michigan Michigan Ohio State (-10.5)
Vanderbilt Vanderbilt vs Tennessee Tennessee Vanderbilt (+2.5)
Oregon Oregon vs Washington Washington Oregon (-6.5)
LSU LSU vs Oklahoma Oklahoma Oklahoma (-10.5)
Alabama Alabama vs Auburn Auburn Alabama (-5.5)

Lines courtesy of FanDuel.

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Expert Week 14 CFB ATS picks

Mississippi (-7.5) vs Mississippi State: Mississippi State Mississippi State +7.5 

Lane Kiffin's squad has been far from a dominant No. 6-ranked team, and needing a fourth-quarter comeback to beat 3-7 Florida at home is the latest evidence. On the flip side, Mississippi State is 5-1 ATS at home.

Iowa (-6.5) vs Nebraska: Iowa Iowa -6.5

Nebraska's showings against the better Big Ten teams imply they should not be trusted, especially now with freshman TJ Lateef under center.  Iowa's four losses came against teams that were ranked at the time. Nebraska isn't that.

Georgia (-13.5) vs Georgia Tech: Georgia Tech Georgia Tech +13.5

Georgia Tech covered and almost won outright as a three-score underdog in Athens a year ago. This game is in Atlanta, and while Georgia is running hot right now, the Yellow Jackets are much better than they were in 2024.

Texas A&M (-2.5) vs Texas: Texas A&M Texas A&M -2.5

I fully expected this spread to be beyond a field goal, so anything under -3 is an easy trigger to pull on Marcel Reed and the undefeated Aggies. This is not a perfect team, but Arch Manning has struggled in too many games to be trusted in this spot.

Miami (-6.5) vs Pittsburgh: Pittsburgh Pittsburgh +6.5

Pittsburgh dispatched a ranked Georgia Tech team last week and could cause more problems for Miami, which has been very beatable when facing the top-end ACC teams. That could manifest itself again in this game. 

Ohio State (-10.5) vs Michigan: Ohio State Ohio State -10.5

Michigan doesn't have the horses on defense to muck this game up the way it did last year, and there's a case to be made Ohio State is better on both sides of the ball. Ryan Day will get this rivalry back on track with a statement win.

Vanderbilt vs Tennessee (-2.5): Vanderbilt Vanderbilt +2.5

While not likely, there's a way into the CFP for Vanderbilt should they win this game in Knoxville. I think Diego Pavia & Co. are up to the task.

Oregon (-6.5) vs Washington: Oregon Oregon -6.5

While this is a tough place to play, I'm not sure Washington is good enough for that to be an equalizer in this spot. Ohio State came into Husky Stadium and won by three scores; Oregon will do something similar this weekend.

LSU vs Oklahoma (-10.5): Oklahoma Oklahoma -10.5

LSU winning by three points at home as a 24.5-point favorite should tell you everything you need to know about the state of this program. Lay the points with Oklahoma.

Alabama vs Auburn (-5.5): Alabama Alabama -5.5

The Crimson Tide will be eager to bounce back after falling to Oklahoma, and with its season on the line, I suspect the Tide will handle their business.


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Chris Gregory Covers.com
Betting Analyst

In his four years on the Covers editorial team, Chris Gregory has helped bolster the site’s golf and college football coverage. He brings a journalism and marketing background to his work as a Publishing Editor and can be found across our site covering the Masters, college football futures, and more.

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