The red-hot Detroit Pistons will be looking to extend their win streak to four games tonight as they visit the last-place New Orleans Pelicans at Smoothie King Center.
Cade Cunningham’s assist total is extremely high, but my Pistons vs. Pelicans predictions are eyeing him to pick apart a poor New Orleans defense.
Read more in my NBA picks for Wednesday, January 21.
Pistons vs Pelicans prediction
Pistons vs Pelicans best bet: Cade Cunningham Over 10.5 assists (+102)
While the Detroit Pistons are a well-oiled machine, Cade Cunningham is undoubtedly the focal point of this team, leading the way with 25.7 points, 9.8 assists, and 5.9 rebounds per game. The former first overall pick is an incredible playmaker, and he ranks second in the Association in dimes.
No matter the opponent, Cunningham finds a way to facilitate the rock at a high level. The guard has cashed the Over in assists in four of his last six outings, and he just had 14 dimes on Monday against the Boston Celtics.
Cunningham is up against a poor New Orleans Pelicans perimeter defense that is allowing over nine assists per night to point guards, and they’re considered an easy matchup for the position. Also, NOLA is giving up 28.9 dimes per contest overall, which is second-worst in the NBA.
He’ll cook tonight as a passer.
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Pistons vs Pelicans same-game parlay
Jalen Duren is a physical specimen down low, and he’s proving to be an irreplaceable piece to the Pistons on both ends of the floor. On the boards, Duren is a monster, and he’s averaging 10.7 rebounds per contest.
While Duren has only cashed the Over once in his last four appearances, he’s up against a Pelicans team that is giving up over 15 boards per night to centers. Duren will take advantage and have a big game on the glass.
Trey Murphy is one of the lone bright spots for the Pels. He’s averaging a career-best 22.2 points, and the University of Virginia product is cooking in January.
This month, Murphy is averaging 29.1 PPG. He’s hit the Over in points in eight straight contests, and during that span, Murphy had three 30+ performances, and also a 42-point eruption.
Pistons vs Pelicans SGP
- Cade Cunningham Over 10.5 assists
- Jalen Duren Over 10.5 rebounds
- Trey Murphy Over 20.5 points
Our "from downtown" SGP: Robinson on a roll
Duncan Robinson is on fire from deep right now, cashing the Over in made triples in five consecutive games.
Pistons vs Pelicans SGP
- Cade Cunningham Over 10.5 assists
- Jalen Duren Over 10.5 rebounds
- Trey Murphy Over 20.5 points
- Duncan Robinson Over 2.5 threes
Pistons vs Pelicans odds
- Spread: Pistons -9.5 | Pelicans +9.5
- Moneyline: Pistons -420 | Pelicans +330
- Over/Under: Over 234.5 | Under 234.5
Pistons vs Pelicans betting trend to know
The Pistons have hit the Moneyline in 31 of their last 40 games (+16.70 Units / 16% ROI). Find more NBA betting trends for Pistons vs. Pelicans.
How to watch Pistons vs Pelicans
| Location | Smoothie King Center, New Orleans, LA |
| Date | Wednesday, January 21, 2026 |
| Tip-off | 8:00 p.m. ET |
| TV | FDSN Detroit, GCSEN |
Pistons vs Pelicans latest injuries
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