The Chicago White Sox have won six of the last nine and are priced at -110 to come out on top in tonight's series opener.
My White Sox vs. Guardians predictions and MLB picks suggest the road team should be favored against a Cleveland team missing its best player.
Who will win White Sox vs Guardians today: White Sox moneyline (-110)
Slade Cecconi has allowed six runs over his last five starts and managed a 1.88 ERA, despite a 3.97 xFIP and 4.02 FIP.
Opponents hit an unsustainably low .229 on balls put in play over the past month. Even more unsustainable is that he has stranded 93.3% of baserunners, which is miles above his 71% career average.
The Chicago White Sox rank ninth in ISO and 12th in wOBA vs. righties since June 1, making them a strong candidate to bring Cecconi back to earth.
Back the White Sox up to -120.
COVERS INTEL: Slade Cecconi ranks in the 24th percentile in expected batting average allowed.
White Sox vs Guardians Over/Under pick: Under 8.5 (-110)
This total is half a run too high. Cecconi has not pitched as well as his numbers suggest, but it’s not as if he should be getting shelled. He simply deserves middling results rather than high-end. In a pitcher’s park, I don’t think he’ll get blown up entirely.
The Cleveland Guardians are missing a couple of key bats, and it shows. They rank 24th in wOBA and 29th in ISO against righties at home since June 1.
Davis Martin has allowed only five runs through six starts against Bottom-10 teams in OPS vs. right-handed pitching. Bet the Under to -125.
- ML/RL bets: 46-37, -1.35 units
- Over/Under bets: 45-34-4, +6.79 units
White Sox vs Guardians weather
White Sox vs Guardians odds
- Moneyline: White Sox -110 | Guardians -110
- Run line: White Sox -1.5 (+150) | Guardians +1.5 (-175)
- Over/Under: Over 8.5 (-110) | Under 8.5 (-110)
White Sox vs Guardians trend
The White Sox have cashed the moneyline in 26 of their last 45 games (+9.4 units, 19% ROI). Find more MLB betting trends for White Sox vs. Guardians.
How to watch White Sox vs Guardians and game info
| Location | Progressive Field, Cleveland, OH |
| Date | Thursday, July 2, 2026 |
| First pitch | 6:40 p.m. ET |
| TV | CHSN, Guardians.TV |
| White Sox starting pitcher | Davis Martin (9-3, 3.00 ERA) |
| Guardians starting pitcher | Slade Cecconi (4-6, 4.19 ERA) |
White Sox vs Guardians latest injuries
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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