The Cleveland Guardians and St. Louis Cardinals wrap up a three-game set this afternoon at Busch Stadium, with the first pitch scheduled for 1:15 p.m. ET.
With both lineups having success against today's starters, my Guardians vs. Cardinals predictions are eyeing the Over.
Read more for my MLB picks for Wednesday, April 15.
Who will win Guardians vs Cardinals today: Cardinals moneyline (-110)
The St. Louis Cardinals bounced back in Game 2 of this series, grabbing a 6-5 victory in extra innings after losing the opener. The Cardinals have now won four of their last five against the Cleveland Guardians, sweeping them last season.
The NL Central club is 6-5 at home, and it's up against the struggling Slade Cecconi, who has a 5.75 ERA after surrendering 10 earned runs across three outings.
Cecconi has particularly struggled away from the friendly environs of Progressive Field, allowing all of his runs on the road so far.
COVERS INTEL: Cardinals starter Dustin May was better last time out, only allowing one earned run after a pair of horrible starts to begin the campaign.
Guardians vs Cardinals Over/Under pick: Over 8.5 (-115)
Neither the Cardinals nor the Guardians strike out often as a rule, with the lineups ranking 23rd and 24th, respectively, in strikeout rate this season.
May improved in his most recent outing, but his ERA still sits at 9.45 through three appearances. The Guardians don't have an explosive offense, but they do make a lot of contact, with Jose Ramirez and Rookie of the Year candidate Chase DeLauter both boasting a K% below 18.
May doesn't miss many bats, but neither does Cecconi.
Cleveland's right-hander has also been prone to the home run ball, allowing three already this season after watching 24 soar over the fences in 2025. Jordan Walker could pad his already impressive breakout resume, as he's sitting in the 99th percentile or BETTER in average exit velocity, barrel rate, hard-hit rate, bat speed, and expected slug.
Two pitchers who struggle to miss bats against lineups that consistently put the bat on the ball is a recipe for the Over.
- ML/RL bets: 2-1, -1.29 units
- Over/Under bets: 3-0, +2.67 units
Guardians vs Cardinals odds
- Moneyline: Guardians +100 | Cardinals -104
- Run line: Guardians +1.5 (-210) | Cardinals -1.5 (+175)
- Over/Under: Over 8.5 (-110) | Under 8.5 (-110)
Guardians vs Cardinals trend
The St. Louis Cardinals have hit the Game Total Over in 13 of their last 22 games (+4.30 Units / 18% ROI). Find more MLB betting trends for Guardians vs. Cardinals.
How to watch Guardians vs Cardinals and game info
| Location | Busch Stadium, St. Louis, MO |
| Date | Wednesday, April 15, 2026 |
| First pitch | 1:15 p.m. ET |
| TV | MLBN |
| Guardians starting pitcher | Slade Cecconi (0-2, 5.74 ERA) |
| Cardinals starting pitcher | Dustin May (1-2, 9.45 ERA) |
Guardians vs Cardinals latest injuries
Guardians vs Cardinals weather
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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