After lighting up the St. Louis Cardinals on Monday night, the Chicago Cubs will look to keep the bats rolling in tonight's rematch.
Chicago is -106 on the moneyline, and my Cubs vs. Cardinals predictions and MLB picks for Tuesday, July 28, see the Cubs take down the Cardinals once again.
Who will win Cubs vs Cardinals today: Cubs (-112)
Even with right-hander Colin Rea taking the mound for the Chicago Cubs this evening, I still expect the visitors to come out on top.
I don't care that Rea owns a 5.51 ERA, 5.10 xERA, and 1.35 WHIP over his last three outings. The St. Louis Cardinals offense has been lifeless, posting a 68 wRC+, .265 wOBA, and .578 OPS over its last 12 games.
On the other side, right-hander Michael McGreevy has allowed nearly a 52% hard hit rate and over a 15.5% barrel rate across his last three starts. Meanwhile, the Cubs offense has been on a tear, owning a 128 wRC+, .358 wOBA, and .193 ISO over its last 21 games.
Despite Rea's struggles this season, I think the Cubs offense does enough to carry them to a win.
I'll take the Cubs on the moneyline down to -115.
COVERS INTEL: McGreevy owns a poor Batters-Box pitcher rating and grades out poorly in matchup ISO, hard-contact rate, and strikeout rate. He will also face three elite-rated hitters and another with a strong rating.
Cubs vs Cardinals Over/Under pick: Over 8.5 (-121)
With two below-average pitchers on the mound tonight, I have to lean toward the Over, right?
Rea owns a 6.45 ERA, 5.66 xERA, and 1.61 WHIP on the road this season, while allowing an 11.05% barrel rate to opposing hitters. Meanwhile, McGreevy owns a 4.58 expected ERA on the road and has allowed a 41.57% hard hit rate and 9.55% barrel rate.
At least one of these arms is giving up some runs tonight.
While I like the Over 8.5, I wouldn't play it past -125.
- 2026 MLB Record: 343-666, -12.6 Units
Cubs vs Cardinals weather
Should be another hot one in St. Louis, as the weather will be in the upper 80s, with slight winds blowing in.
Cubs vs Cardinals odds
- Moneyline: Cubs -108 | Cardinals +104
- Run line: Cubs -1.5 (+150) | Cardinals +1.5 (-156)
- Over/Under: Over 8.5 (-117) | Under 8.5 (+113)
Cubs vs Cardinals trend
The Chicago Cubs have hit the Moneyline in 16 of their last 21 away games (+11.80 Units / 51% ROI).
Find more MLB betting trends for Cubs vs. Cardinals.
How to watch Cubs vs Cardinals and game info
| Location | Busch Stadium, St. Louis, MO |
| Date | Tuesday, July 28, 2026 |
| First pitch | 7:45 p.m. ET |
| TV | TBS |
| Cubs starting pitcher | Colin Rea (7-7, 4.85 ERA) |
| Cardinals starting pitcher | Micheal McGreevy (4-8, 3.07 ERA) |
Cubs vs Cardinals latest injuries
No notable injuries to report
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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