The Milwaukee Brewers are huge home favorites over the Chicago Cubs ahead of the 7:40 p.m. ET first pitch at American Family Field on Tuesday, Sept. 8.
My top Cubs vs. Brewers predictions and MLB picks point to a comfortable Brewers win, along with the total going Over tonight.
Who will win Cubs vs Brewers today: Brewers -1.5 (47.8%)
For help understanding probabilities, see our odds calculator.
This run line isn’t factoring in Milwaukee Brewers ace Jacob Misiorowski allowing five runs across four innings to the Chicago Cubs last time out, and I fully agree. In fact, I’d back the Brewers to 52.4% on the run line tonight.
After all, Misiorowski has held opposing hitters to a pedestrian .244 wOBA and .127 ISO while spinning an elite 2.25 xERA and 2.28 xFIP across 22 starts at American Family Field over the past two years.
Better yet, he’ll be followed by a bullpen with the sixth-lowest xERA and eighth-lowest xFIP in the second half.
So, with Chicago starter David Peterson allowing six runs across just 3 2/3 innings to the Brewers last week, I expect Milwaukee to win comfortably tonight.
COVERS INTEL: Chicago Cubs starter David Peterson’s 4.96 xERA is the 13th-highest mark among pitchers with at least 120 innings.
Cubs vs Brewers Over/Under pick: Over 7.5 (48.8%)
Both of these offenses continue to roll, so I do expect there to be enough runs to send this total Over the 7.5 number tonight.
Chicago paces the majors in wOBA and xwOBA over the past 30 days, and Milwaukee has also been dangerous with respective second- and seventh-ranked marks.
Additionally, the Cubs rank fifth in wOBA against righties for the season, and Milwaukee is also above average against lefties.
I’d play this Over to 51.2%.
Cubs vs Brewers home run prediction: Jackson Chourio (16.7%)
Brewers star Jackson Chourio has already taken Peterson deep twice across 12 career plate appearances, and the Milwaukee outfielder also sports a high-end .211 ISO against lefties for the year.
I also value Chourio’s current form at the dish. He boasts a monster .259 ISO and 42.1 squared-up contact rate across his past 12 games.
- ML/RL bets: 54-26, +30.45 units
- Over/Under bets: 27-24, +1.62 units
Cubs vs Brewers weather
The roof is expected to be open at American Family Field tonight, with the forecast calling for 83 F, clear skies, and the wind blowing at 8-10 mph.
Cubs vs Brewers odds
- Moneyline: Cubs 35.7% | Brewers 68.8%
- Run line: Cubs +1.5 (54.5%) | Brewers -1.5 (50%)
- Over/Under: Over 7.5 (50%) | Under 7.5 (54.5%)
Cubs vs Brewers trend
The Milwaukee Brewers have covered the run line in 26 of their last 50 games at home (+7.10 Units / 13% ROI). Find more MLB betting trends for Cubs vs. Brewers.
How to watch Cubs vs Brewers and game info
| Location | American Family Field, Milwaukee, WI |
| Date | Tuesday, Sept. 8, 2026 |
| First pitch | 7:40 p.m. ET |
| TV | MARQ, Brewers.TV |
| Cubs starting pitcher | David Peterson (7-8, 5.39 ERA) |
| Brewers starting pitcher | Jacob Misiorowski (14-5, 1.97 ERA) |
Cubs vs Brewers latest injuries
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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