Opening NFL Week 8 Odds and Betting Lines: Chiefs Big MNF Faves

Don't look now, but Patrick Mahomes and the Chiefs are picking up steam. They're huge favorites over the Commanders on MNF after Jayden Daniels exited Week 7 with an injury.

Jason Logan: Senior Betting Analyst at Covers
Jason Logan • Senior Betting Analyst
Oct 21, 2025 • 07:23 ET • 4 min read
NFL Week 8 odds
Photo By - Imagn Images. Patrick Mahomes during the first half of the Chiefs' game vs. the Raiders.

After a wild Sunday, we can look ahead to Week 8 of the 2025 NFL season.

We still have a pair of Monday Night Games to follow, but we could be in for a few high-scoring clashes in the ensuing weekend. 

The highest total on the board is 49.5, when the Chicago Bears meet the Baltimore Ravens, who should see Lamar Jackson return to action.

The week starts with a matchup between teams floundering of late as the Los Angeles Chargers host the Minnesota Vikings on Thursday Night Football.

Meanwhile, the Kansas City Chiefs have found new life and are 9.5-point favorites over the Washington Commanders on Monday Night Football.

NFL odds Week 8

Matchup Spread Moneyline Over/Under
Vikings Vikings
vs
Chargers Chargers
Chargers -3 Vikings +138
Chargers -164
44.5
Jets Jets
vs
Bengals Bengals
Bengals -6.5 Jets +245
Bengals -300
43.5
Bears Bears
vs
Ravens Ravens

Ravens -6.5 Bears +265
Ravens -330
50.5
Dolphins Dolphins
vs
Falcons Falcons
Falcons -7.5 Dolphins +330
Falcons -420
45.5
Browns Browns
vs
Patriots Patriots
Patriots -7 Browns +260
Patriots -320
40.5
Giants Giants
vs
Eagles Eagles
Eagles -7 Giants +265
Eagles -330
43.5
Bills Bills
vs
Panthers Panthers
Panthers +7.5 Bills -460
Panthers +360
46.5
49ers 49ers
vs
Texans Texans
Texans +1.5 49ers -122
Texans +104
41.5
Buccaneers Buccaneers
vs
Saints Saints
Saints +5.5 Buccaneers -235
Saints +194
47.5
Cowboys Cowboys
vs
Broncos Broncos
Broncos -3 Cowboys +130
Broncos -154
48.5
Titans Titans
vs
Colts Colts
Colts -14.5 Titans +750
Colts -1200
46.5
Packers Packers
vs
Steelers Steelers
Steelers +3.5 Packers -176
Steelers +148
44.5
CommandersCommanders
vs
Chiefs Chiefs
Chiefs -10.5 Commanders +460
Chiefs -620
48.5

Lines as of 10-20

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Vikings vs Chargers odds (Thursday, 8:15 p.m. ET, Prime Video)

Opening line

The Vikings have a short week to figure out their starting quarterback for Thursday's trip to L.A. Veteran Carson Wentz couldn’t get Minnesota a win over Philadelphia, and we could see J.J. McCarthy back from injury in Week 8. The Chargers opened as 2.5-point home chalk with the total at 43.5 O/U.

Also see: full Thursday Night Football odds

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Jets vs Bengals odds (Sunday, 1:00 p.m. ET, CBS)

Opening line

The Bengals are coming off a mini-bye after beating the Steelers last Thursday. The Jets benched QB Justin Fields in Week 7, and his starting spot isn’t guaranteed for this Week 8 game. Star DB Sauce Gardner is also a question mark after suffering a concussion on Sunday. Cincinnati opened at -4.5 and jumped to -5.5 before coming back to the original spread. This total opened at 44.5 and dropped to 43.5 points.

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Bears vs Ravens odds (Sunday, 1:00 p.m. ET, CBS)

Opening line

Baltimore is hoping to have Lamar Jackson and a few more starters back on the field in Week 8 after a much-needed bye. The Ravens opened as 6.5-point home favorites, while some books have climbed to the key number of a touchdown. This total is at 49.5 points.

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Dolphins vs Falcons odds (Sunday, 1:00 p.m. ET, CBS)

Opening line

The Falcons flopped on the road at San Francisco on Sunday night, and QB Michael Penix Jr. suffered an ankle injury. However, he told reporters he felt fine after the game and will be a big name to watch at practice this week. Atlanta opened as a 7.5-point home favorite against the Dolphins with the total at 45.5 points.

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Browns vs Patriots odds (Sunday, 1:00 p.m. ET, FOX)

Opening line

The Patriots stay hot on a four-game winning streak (4-0 ATS) and opened as 7-point home favorites vs. Cleveland in Week 8. This total hit the board at the short number of 40.5 points.

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Giants vs Eagles odds (Sunday, 1:00 p.m. ET, FOX)

Opening line

The Giants upset the Eagles a few weeks back on TNF, but now travel to Lincoln Financial Field, getting seven points in Week 8. Philadelphia’s offense sprang to life in the win over Minnesota on Sunday, which has helped push this total from 41.5 to 43.5 in the first 12 hours of action.

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Bills vs Panthers odds (Sunday, 1:00 p.m. ET, FOX)

Opening line

The Panthers are riding a three-game winning streak for the first time since 2021, yet still catch as many as 7.5 points at home to Buffalo in Week 8. The Bills are coming off a bye week and should look much healthier in an attempt to snap a two-game skid. The total opened at 46.5 and jumped to 47.5 points.

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49ers vs Texans odds (Sunday, 1:00 p.m. ET, FOX)

Opening line

Houston is on a short week after losing to Seattle on Monday. The look-ahead line had the Texans as 1.5-point home chalk, but the official Week 8 opening spread installed Houston as 1.5-point home dogs. The 49ers are hoping to get QB Brock Purdy and WR Ricky Pearsall back for this matchup. The total opened at 41.5 O/U.

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Buccaneers vs Saints odds (Sunday, 4:05 p.m. ET, FOX)

Opening line

After a loss to Detroit on Monday, the Buccaneers opened as 5.5-point road favorites at New Orleans in Week 8. Tampa Bay lost WR Mike Evans to a broken collarbone versus the Lions. This total opened at 47.5 points.

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Cowboys vs Broncos odds (Sunday, 4:25 p.m. ET, CBS)

Opening line

The Broncos squeaked out a wild win over New York on Sunday and opened as field-goal faves against another NFC East team in Week 8. Dallas put up a pile of points in a win over Washington in Week 7. This total opened at 47.5 and climbed to 48.5 with initial action on the Over.

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Titans vs Colts odds (Sunday, 4:25 p.m. ET, CBS)

Opening line

Indianapolis put in another impressive performance with a win over the Chargers in Week 7 and opened as 14.5-point home chalk against the Titans. Tennessee could be without WR Calvin Ridley, DT Jeremy Simmons, and CB L'Jarius Sneed for Week 8. This total opened at 44.5 and quickly swelled to 46.5 points with early action on the Over.

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Packers vs Steelers odds (Sunday, 8:20 p.m. ET, NBC)

Opening line

The Steelers get a mini-bye to lick their wounds from a Thursday loss in Week 7. Pittsburgh opened as a 3-point home underdog for this non-conference clash on Sunday Night Football. The total hit the board at 43.5 and climbed to 44.5 points.

Also see: full Sunday Night Football odds

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Commanders vs Chiefs odds (Monday, 8:15 p.m. ET, ABC/ESPN)

Opening line

Another NFC vs. AFC affair is in the prime-time spotlight with Washington traveling to Arrowhead Stadium to face Kansas City. The Chiefs were as short as 4.5-point home chalk on look-ahead lines before the results of Week 7. But after Jayden Daniels left with a hamstring injury and KC crushed Las Vegas 31-0, oddsmakers reopened this spread at Kansas City -9.5. The look-ahead total was 50.5 O/U, but officially opened at 48.5 points.

Also see: full Monday Night Football odds

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Best NFL bets this week

Looking for our favorite spread, total, and NFL prop bets for this week's action? Check out our best free NFL picks from the Covers staff!

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Jason Logan Senior Industry Analyst Covers.com
Senior Betting Analyst

In his 20 years with Covers, lead NFL betting analyst; has seen it all and bet it all. Through the wild west of early Internet gambling to lobbying for legalized sports betting to our brave new wagering world, Jason has been a consistent source of actionable info and entertainment for squares and sharps alike. Since joining the Covers team back in 2005, he honed his handicapping skills to provide audiences with the most thorough insights, blending traditional capping methods with advanced modelling and predictive analysis. Jason has studied the ins and outs of the sports betting business, learning from some of the most successful gamblers in the industry and the biggest sportsbook operators on the planet. He is under center for Covers during NFL season as our top NFL expert, taking the points in his infamous NFL Underdogs column and representing the Covers Community at the Super Bowl. While he lives for football season, Jasons first love is basketball and that shows in his in-depth NBA, NCAA, and WNBA betting breakdowns. On top of being a mainstay in media from coast to coast; WPIX, PHL17, Fox 5 San Diego, WGNO, TSN, SportsNet, ESPN Radio; he had his analysis featured in USA Today, MSNBC, ESPN, the Wall Street Journal, CBS, Bloomberg, the L.A. Times, the New York Times and other major publications. You can also find JLo stuffing all the top picks and predictions he can into 10 minutes as the host of Covers; flagship podcast, The Sharp 600.

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