My Ravens vs. Colts prediction favors Baltimore to cover as a slim 3.5-point favorite when Lamar Jackson and the visiting squad open their season against Indianapolis this afternoon.
The visitors are expected to handle business on the road behind their lethal offensive duo of Jackson and Derrick Henry.
Read more in my NFL picks for today's Week 1 contest, with kickoff scheduled for 1 p.m. ET at Lucas Oil Stadium in Indianapolis, Ind.
TOP PICK
Ravens vs Colts prediction: Ravens -3.5
The Baltimore Ravens get a tough assignment in Week 1 against the Indianapolis Colts, who have Daniel Jones back from an Achilles tear while also possessing an improved defense.
This number makes sense, though. I do not expect this game to be a blowout, but the rushing combo of Lamar Jackson and Derrick Henry will be a handful for the Colts' defensive front.
Baltimore has a new OC and a new head coach, and I believe the Ravens will lean heavily on their QB and running back on the ground.
The Colts should keep things interesting, especially with Jonathan Taylor capable of controlling the game on the ground, but Baltimore simply has more difference-makers on both sides of the ball, and I trust Jackson and Henry to eventually wear Indy down.
Expect one of the Ravens' two offensive superstars to make the difference as Baltimore pulls away enough to cover.
Play up to 50%.
COVERS INTEL: Jackson averaged 5.9 yards per carry on the road last season across seven games. At home, his average sat at just 4.4 YPC. 
Ravens vs Colts combo
Ravens -3.5
Lamar Jackson Over 39.5 rushing yards
Daniel Jones Over 225.5 passing yards
Baltimore's offensive weapons give them the edge in Indianapolis, even if this remains competitive.
Jackson is always dangerous with his legs, and he cleared 30 rushing yards in three of Baltimore's final four road games last season. With Henry demanding attention from Indy's front seven, Lamar should have opportunities to find space.
Jones, meanwhile, averaged 238.5 passing yards last season and cleared 225 in seven of his first 10 games before going down.
Baltimore's pass defense struggled badly in 2025, and with Keenan Allen, Alec Pierce, Josh Downs, and others at his disposal, Jones should have enough opportunities to surpass this modest number.
Ravens vs Colts combo
- Ravens -3.5
- Lamar Jackson Over 39.5 rushing yards
- Daniel Jones Over 225.5 passing yards
Ravens vs Colts touchdown scorer: Derrick Henry
Henry remains one of Baltimore's highest-usage weapons, especially near the goal line. He scored 16 rushing touchdowns last season, with 10 coming from inside the 20-yard line.
The former Alabama star has also made a habit of balling out from the jump. He's found the end zone in two of the last three seasons in Week 1.
Henry's physical running style makes him extremely difficult to stop in short-yardage situations, and if Baltimore gets into the red zone, expect the veteran to get plenty of opportunities to finish the drive.
Play up to 65%.
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Ravens vs Colts player prop: Keenan Allen Over 24.5 receiving yards
Allen had some off-field troubles recently, but he's expected to play Sunday, and the six-time Pro Bowler gives Jones another reliable target. At Kalshi, Allen's total of 25+ receiving yards feels like a steal. He averaged 45.7 yards per game with the Chargers last season while catching 81 passes.
He won't be a focal point in this offense, but Allen remains a reliable possession receiver who can work underneath and move the chains. Baltimore's pass defense was vulnerable last season, which should give the veteran enough opportunities to clear this number in Week 1.
Play up to 55%.
Ravens vs Colts odds
For help understanding probabilities, see our odds calculator.
- Spread: Ravens -3.5 | Colts +3.5
- Over/Under: Over 47.5 (52%) | Under 47.5 (49%)
- Moneyline: Ravens 61% | Colts 40%
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Ravens vs Colts weather
Weather in Indianapolis will have no impact since Lucas Oil Stadium is a dome.
Check out our NFL weather page for up-to-date info on every matchup.
Ravens vs Colts trend to know
The road team is 4-0 ATS in their last four meetings. Find more NFL betting trends for Ravens vs. Colts.
How to watch Ravens vs Colts
| Location | Lucas Oil Stadium, Indianapolis, Ind. |
| Date | Sunday, Sept. 13, 2026 |
| Kickoff | 1 p.m. ET |
| TV | CBS |
Ravens vs Colts latest injuries
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