We’re rolling into the home stretch of the regular season, and this week’s slate is packed with playoff implications.
The New England Patriots have a chance to clinch the AFC East for the first time in the post-Tom Brady era, and their upcoming matchup against the Buffalo Bills tops my favorite NFL picks for Week 15.
Week 15 NFL moneyline picks
| Matchup | Pick |
|---|---|
 Falcons vs  Buccaneers |
-235 |
 Raiders vs  Eagles |
-800 |
 Commanders vs  Giants |
-134 |
 Chargers vs  Chiefs |
+190 |
 Browns vs  Bears |
-420 |
 Cardinals vs  Texans |
-560 |
 Jets vs  Jaguars |
-1100 |
 Ravens vs  Bengals |
+124 |
 Bills vs  Patriots |
+100 |
 Panthers vs  Saints |
-154 |
 Colts vs  Seahawks |
-1200 |
 Lions vs  Rams |
-250 |
 Titans vs  49ers |
-1000 |
 Packers vs  Broncos |
-134 |
 Vikings vs  Cowboys |
-280 |
 Dolphins vs  Steelers |
-190 |
Lines courtesy of FanDuel as of 12-10.
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Expert Week 15 NFL moneyline picks
Falcons vs. Buccaneers: Buccaneers (-235)
Tampa Bay is reeling as losers of four of its last five, but the cavalry is returning.
There’s a good chance Mike Evans is set to come off IR, marking the first time all season that Evans, Chris Godwin, and Emeka Egbuka will be on the field at the same time.
If you can’t beat Kirk Cousins in prime time, you don’t deserve a spot in the playoffs.
Read our full Falcons vs. Buccaneers predictions.
Raiders vs. Eagles: Eagles (-800)
Philadelphia had every opportunity to beat the Chargers but kept giving the game away, as Jalen Hurts’ four interceptions led to the Eagles’ third consecutive loss.
Luckily, a matchup against the 2-11 Raiders allows them to play sloppily and still emerge victorious.
Commanders vs. Giants: Giants (-134)
If you’re a fan of either of these teams, you’re rooting for a loss in hopes of landing the No. 1 pick.
Both defenses have been downright dreadful, but I’ll side with a Giants team that has performed much better in the Meadowlands than on the road.
Chargers vs. Chiefs: Chargers (+190)
Retirement is calling for Travis Kelce, Patrick Mahomes suddenly looks human, and Kansas City is staring at a soft re-tool this offseason to address concerns on both sides of the ball.
Meanwhile, the Chargers’ defense boasts a Top 5 mark in third-down stop rate, and this is a team capable of winning grind-it-out battles with the best of them.
Browns vs. Bears: Bears (-420)
It's expected to be around -12 °C in the Windy City, setting the stage for a run-heavy game plan from both offenses.
With the Bears boasting the second-most rushing yards per game, Ben Johnson has the blueprint to lean on De’Andre Swift and Kyle Monangai for a big day as touchdown favorites.
Cardinals vs. Texans: Texans (-560)
Defense has been the name of the game during the Texans’ five-game win streak, most recently holding Mahomes to the worst start of his career.
Shutting down Jacoby Brissett and the Cardinals will be a layup for Houston.
Jets vs. Jaguars: Jaguars (-1100)
DUVAAALLLLL!
Liam Coen's team has fired off four straight dubs, and they're staring down the barrel of just their third AFC South division title in 25 years.
As double-digit chalk against a Jets team that just lost to Tennessee, the good juju is set to continue for Jacksonville.
Ravens vs. Bengals: Bengals (+124)
It’s become clear Lamar Jackson is more than just limited, and when you force him to operate solely as a pocket passer, the Ravens’ offense loses serious juice.
Baltimore has lost two straight, while Cincinnati’s offense continues to put up points following the return of Joe Burrow. I’ll take a shot on Cincy as a short home dog.
Bills vs. Patriots: Patriots (+100)
New England already got the best of the Bills in Buffalo on Sunday Night Football, the only time Josh Allen & Co. have fallen short at Highmark Stadium this season.
Fresh off a bye, the Patriots will prevail at home and clinch first place in the AFC East.
Panthers vs. Saints: Panthers (-154)
Although Carolina fell short in Week 10 against the Saints, it's fresh off the high of an upset win over the Rams, followed by a bye to get healthy and prepare for this one.
Carolina is within striking distance of its first divisional title since 2015, while New Orleans is just 1–5 at home this season.
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Colts vs. Seahawks: Seahawks (-1200)
A comfy lead atop the AFC South for Indy has vanished in quick order, and the Colts will now be without Daniel Jones for the remainder of the season.
CB Charvarius Ward and OT Braden Smith have also landed on the injury report, and in classic Colts fashion, 44-year-old Philip Rivers might be under center for this one.
A month ago, I wanted this game flexed to prime time. Now it’s going to be an absolute rout for the Seahawks.
Lions vs. Rams: Rams (-250)
Detroit may have won the war against Dallas on TNF, but the Lions lost Brian Branch in the late stages of the game to a torn Achilles. With their All-Pro safety done for the season, Los Angeles’ offense will feast at SoFi.
The Rams stay atop the NFC West with a big home win.
Titans vs. 49ers: 49ers (-1000)
San Francisco has taken full advantage of a soft slate over the past month, and that trend will continue when the Niners play host to Tennessee.
Robert Saleh is doing yeoman’s work keeping this patched-together 49ers defense afloat, and San Fran will only benefit further from the extra week to prep.
Packers vs. Broncos: Packers (-134)
Both teams are pretty evenly matched, but the glaring difference remains at quarterback, where Jordan Love is quietly putting together an MVP-worthy season, boasting a 105.4 passer rating and a 22-4 TD-INT ratio heading into this showdown at Mile High.
Denver has scraped by with unimpressive wins over Las Vegas and Washington, and the No. 1-seed Packers will finally put an end to the Broncos’ home win streak.
Vikings vs. Cowboys: Cowboys (-280)
Dak Prescott has been incredible against the blitz this season, so Dallas matches up well against a Minnesota defense that brings the heat at the highest rate in the NFL.
The Cowboys' playoff chances may have been squandered after last week’s loss in Detroit, but "America’s Team" will get the best of J.J. McCarthy and a lost Vikings season.
Dolphins vs. Steelers: Steelers (-190)
It’s tough to trust either one of these teams, but Pittsburgh is better equipped for cold-weather games.
I’ll back it to stay atop the division with a win in front of the Steelers faithful, where the home fans won’t be booing Renegade this time around.
My NFL moneyline record is 131-77 this season for +1.37 units.
Odds are correct at the time of publishing and are subject to change.
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