The Houston Texans look to extend their winning streak to six games when they host the Arizona Cardinals on Sunday afternoon.
Houton's last three wins came as underdogs against the Bills, Colts, and Chiefs, and now the Texans are big home favorites against the lowly Cardinals.
My Cardinals vs. Texans predictions focus on Nico Collins continuing his hot streak against a poor passing defense.
Find out more in my best NFL picks for December 14.
Cardinals vs Texans prediction
Cardinals vs Texans Best bet: Nico Collins Over 74.5 receiving yards (-114)
Nico Collins is far and away the top wide receiver for the Houston Texans. He leads the Texans with 61 catches on 103 targets for 916 yards in 12 games, an average of 76.33 yards per contest.
Collins is coming off his third game of at least 100 receiving yards this season, racking up 121 yards on just four catches, including a long of 53. That’s now two straight games and five of his last six in which he’s had at least 75 receiving yards.
The Arizona Cardinals allow 224.3 passing yards per game, and Collins should get his fair share on Sunday afternoon.
Cardinals vs Texans same-game parlay
The Texans should be able to keep this a low-scoring game against the Cardinals while covering the spread.
Houston allows a league-low 16 points per game while scoring just 22 points.
Cardinals vs Texans SGP
- Nico Collins Over 74.5 receiving yards
- Texans -9.5
- Under 42.5
Our big-ticket SGP: Woody Makes his Mark!
I’m adding Collins to score and a Woody Marks touchdown for this big-ticket same-game parlay.
They’re tied for the team lead with five touchdowns each, so we could get a Collins TD in the first half before the Texans turn it over to the running game to close things out.
Cardinals vs Texans SGP
- Nico Collins Over 74.5 receiving yards
- Texans -9.5
- Under 42.5
- Nico Collins anytime touchdown
- Woody Marks anytime touchdown
Cardinals vs Texans odds
- Spread: Cardinals +7.5 (-110) | Texans -7.5 (-110)
- Moneyline: Cardinals +300 | Texans -375
- Over/Under: Over 43.5 (-115) | Under 43.5 (-105)
More NFL picks and odds from Covers
Cardinals vs Texans trend to know
Houston has only hit the game total Over in six of its last 22 games (-10.50 Units / -43% ROI). Find more NFL betting trends for Cardinals vs. Texans.
How to watch Cardinals vs Texans
| Location | NRG Stadium, Houston, TX |
| Date | Sunday, December 14, 2025 |
| Kickoff | 1:00 p.m. ET |
| TV | FOX |
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