We have one of Sunday’s biggest spreads for the meeting between the Tennessee Titans and the San Francisco 49ers.
The bookies might expect an easy win for the home team, but the Titans are showing signs of improvement and picked up one of their two wins last time out.
However, my Titans vs. 49ers predictions expect Tennessee's improvement to be more evident in the points total than in the final result.
Don’t miss our NFL picks for December 14.
Titans vs 49ers prediction
Titans vs 49ers Best bet: Over 44.5 (-110)
The points total is the best line to attack this Sunday. Both teams have hit the Over in the majority of their games this season, with eight in 13 for the Tennessee Titans and seven for the San Francisco 49ers.
However, if you dig down into recent results, then five of the Titans' past seven games have hit that mark.
In no way are the Titans a good football team, but they’re certainly one that’s improving. Cam Ward was dealt a bad hand with a poor offensive line and a rookie receiver corps, but as the season has progressed, he’s managed to put things together.
In the past month, they’ve faced three of the top four teams per defensive DVOA and averaged 22.6 points scored in those games. That’s good going when they’ve averaged just 15.5 points across the whole season.
The 49ers are averaging 23.6 points per game, and with the Titans showing real signs of improvement, we should see the game total smashed.
With the 49ers likely to have a big game themselves, we should expect the Titans to put up points too, even if it’s not enough to win or even cover the spread.
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Titans vs 49ers same-game parlay
Chimere Dike has had a lot of volume this season. He’s had 11 receptions in his past three games and 19 targets. With the Titans likely chasing the game, we’ll see Cam Ward passing a lot.
We’re finishing off by backing Dike to also score a touchdown. He’s only scored three times, but two have come in the past three weeks. Over the past five games, we’ve seen Dike average one red zone target per game, more than anybody else on the roster.
Titans vs 49ers SGP
- Over 44.5
- Chimere Dike Over 3.5 receptions
- Chimere Dike anytime touchdown
Our big-ticket SGP: Mac to the House!
Tyjae Spears has cleared his receiving yards mark in five of his past six, and his ability as a pass catcher is underrated. The 49ers are allowing 35.9 receiving yards per game to opposing running backs this season.
For the final leg, we’re backing Christian McCaffrey to have two or more touchdowns. Only four teams have allowed more touchdowns to running backs than the Titans, and McCaffrey has multiple touchdowns in three of his previous seven games.
Titans vs 49ers SGP
- Over 44.5
- Chimere Dike Over 3.5 receptions
- Chimere Dike anytime touchdown
- Tyjae Spears Over 21.5 receiving yards
- Christian McCaffrey 2+ touchdowns
Titans vs 49ers odds
- Spread: Titans +12.5 (-110) | 49ers -12.5 (-110)
- Moneyline: Titans +650 | 49ers -1000
- Over/Under: Over 44.5 (-110) | Under 44.5 (-110)
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Titans vs 49ers trend to know
The Tennessee Titans have hit the game total Over in 13 of their last 20 games. Find more NFL betting trends for Titans vs. 49ers.
How to watch Titans vs 49ers
| Location | Levi's Stadium, Santa Clara, CA |
| Date | Sunday, December 14, 2025 |
| Kickoff | 4:25 p.m. ET |
| TV | FOX |
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