The San Francisco 49ers hit the road to do battle with the Philadelphia Eagles at Lincoln Financial Field, with kickoff at 4:30 p.m. ET.
My 49ers vs. Eagles predictions back the reigning Super Bowl Champions to come away with a decisive victory tonight.
Find out why in my NFL picks for this playoff clash on January 11.
49ers vs Eagles prediction
49ers vs Eagles Best bet: Eagles -5 (-115)
The San Francisco 49ers rank 31st in the league in defensive success rate since Nick Bosa tore his ACL in Week 3. That stop unit has been even worse after losing All-Pro linebacker Fred Warner to a season-ending injury in October.
San Francisco's offense was held to three points and 173 yards in their season finale and now travel country wide to face an elite Philadelphia Eagles defense. Philly rested plenty of starters last week and ranked second in the NFL in defensive success rate between Weeks 8 and 17.
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49ers vs Eagles same-game parlay
Saquon Barkley started off slow this season but picked up steam, averaging 100 rushing yards per game over the last four weeks. The 49ers rank 31st in success rate against the run, and their linebacker corps has been decimated by injuries to Warner, Tatum Bethune, Dee Winters, and Nick Martin.
That injury-plagued LB corps has struggled to defend tight ends, allowing 99 receptions and 10 touchdowns to the position. That's bad news against Dallas Goedert, who leads the Eagles in TDs (11) and red-zone targets (15).
49ers vs Eagles SGP
- Eagles -5.5
- Saquon Barkley Over 79.5 rushing yards
- Dallas Goedert anytime touchdown
Our big-ticket SGP: Cheesy Mac!
Barkley will gash a brutal run defense, and 49ers Pro Bowl RB Christian McCaffrey should also have success. He's rushed for more than 70 yards in five of his last seven games while scoring a touchdown in six of those contests.
The two games during that span in which C-Mac had fewer than 70 rushing yards were against Cleveland and Seattle, who rank in the Top 5 in defensive rush success rate, while Philly ranks 18th in that metric.
49ers vs Eagles SGP
- Saquon Barkley Over 79.5 rushing yards
- Saquon Barkley anytime touchdown
- Christian McCaffrey Over 57.5 rushing yards
- Christian McCaffrey anytime touchdown
49ers vs Eagles game predictions
49ers vs Eagles moneyline prediction
With the Eagles boasting a far better defense and playing at home against a West Coast team, they should win here.
Eagles 27-20
49ers vs Eagles spread prediction
San Fran's usually explosive offense has been contained by good defenses, especially without Ricky Pearsall to stretch the field. If the 49ers can't score at their usual rate, they won't be able to keep up with the points their defense leaks.
Eagles -5.5
49ers vs Eagles Over/Under prediction
Both teams could be getting back future Hall-of-Fame offensive tackles in Trent Williams and Lane Johnson. Tackles don't move lines, so we can get a betting edge by going against the movement on the total and betting the Over.
Over 44.5
49ers vs Eagles odds
- Spread: 49ers +5.5 (-110) | Eagles -5.5 (-110)
- Moneyline: 49ers +198 | Eagles -240
- Over/Under: Over 44.5 (-110) | Under 44.5 (-110)
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49ers vs Eagles trend to know
The 49ers have cashed the first half Over in their last eight road games (+8.00 Units / 89% ROI). Find more NFL betting trends for 49ers vs. Eagles.
How to watch 49ers vs Eagles
| Location | Lincoln Financial Field, Philadelphia, PA |
| Date | Sunday, January 11, 2026 |
| Kickoff | 4:30 p.m. ET |
| TV | FOX |
49ers vs Eagles latest injuries
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