Lane Kiffin and the Mississippi Rebels bounced back in emphatic fashion after suffering their first loss of the season, going into Norman and securing a statement victory over Oklahoma.
With that win, the path forward opens up as the Rebels continue their push toward a College Football Playoff berth — something the program has yet to achieve.
However, that pursuit leaves no room for missteps, beginning this weekend as the South Carolina Gamecocks visit Oxford.
My South Carolina vs. Mississippi predictions zero in on a player prop that backs the Rebels’ potent passing attack, along with additional college football picks for this key SEC showdown on Saturday, November 1.
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South Carolina vs Mississippi prediction
South Carolina vs Mississippi best bet: Trinidad Chambliss Over 267.5 passing yards (-114)
Trinidad Chambliss didn’t begin the season as the Mississippi Rebels' starting quarterback, but there’s no question that it’s his job now.
Chambliss took over the job after Austin Simmons suffered an injury in Week 2, and hasn’t looked back since. The freshman is a dual-threat QB who has thrown for 1,864 yards with nine touchdowns and one interception, while adding another 376 yards and five scores on the ground.
He’s thrown for 300+ yards in four of his six games this season, including putting up 315 yards in a huge bounce-back win for the Rebels, where they went into Norman and took care of business of the Sooners, winning 34-26.
It showcased the resiliency of this Rebels team following a gut-wrenching loss to Georgia, where they gave up a late lead.
Now, the schedule opens up for Mississippi, and a spot in the College Football Playoff is a real possibility. But that means not letting up, starting this week against the South Carolina Gamecocks.
South Carolina hasn’t been able to replicate the magic of their 11-win season last year. But the Gamecocks were oh-so-close to upsetting Alabama last week. However, after that disappointment, the Gamecocks should come back down to Earth and are set up for a letdown.
That doesn’t bode well against this explosive Rebels offense. Nor does the fact that South Carolina ranks 117th in the country in defensive success rate on dropbacks.
I’m betting Chambliss keeps chucking it against this Gamecocks defense and goes Over this number for the fifth time in seven games.
South Carolina vs Mississippi same-game parlay
Like I said, this feels like wrong place, wrong time for South Carolina.
The Gamecocks gave it their all against Alabama last week, but gave away the game at the end. The offense has also struggled for South Carolina, ranking 87th in the country in EPA per play and 127th in success rate.
Meanwhile, Mississippi has been sneaky good on defense, ranking 22nd in EPA per play. Mississippi has the goods to cover this number at home.
If the Rebels have a weakness on that side of the ball, it’s their run defense. Mississippi ranks 76th in EPA per rush and 115th in success rate against the rush. That combined with an aggressive defensive line means South Carolina could try to run a little more with QB LaNorris Sellers.
When healthy, Sellers is an electric runner, and hw has gone for 67 or more yards twice in the last four games. I love Sellers to eclipse his rushing yards prop this week in a situation where he could be running for his life.
South Carolina vs Mississippi SGP
- Trinidad Chambliss Over 267.5 passing yards
- Mississippi -12.5
- LaNorris Sellers Over 30.5 rushing yards
Our deep-ball SGP: The Wright stuff
South Carolina can give up explosive plays in the passing game, and Dae'Quan Wright is Mississippi's best deep threat. Let's take him to score his third TD of the year.
South Carolina vs Mississippi SGP
- Trinidad Chambliss Over 267.5 passing yards
- Mississippi -12.5
- LaNorris Sellers Over 30.5 rushing yards
- Dae'Quan Wright anytime TD
South Carolina vs Mississippi game predictions
South Carolina vs Mississippi moneyline prediction
Mississippi is a fourth-quarter collapse against Georgia away from being undefeated. Lane Kiffin can have a bad game every now and then, but South Carolina isn't set up to be one of those teams. The Gamecocks are just struggling too much on both sides of the ball, and are coming off a heartbreaking loss to Alabama.
South Carolina vs Mississippi spread prediction
This number feels close to right, but I would lean toward Mississippi up to -13.5. The Rebels' biggest weakness is their run defense, and South Carolina ranks 116th in EPA per rush and 133rd in rush success rate. At home, Mississippi will be able to pull away from the Gamecocks late.
South Carolina vs Mississippi Over/Under prediction
I'd lean Under this number. Mississippi should do its part when it comes to scoring, but South Carolina probably won't, having scored 22 points or fewer in five of six SEC games.
South Carolina vs Mississippi odds
- Spread: South Carolina +12.5 | Mississippi -12.5
- Moneyline: South Carolina +380 | Mississippi -460
- Over/Under: Over 55.5 | Under 55.5
South Carolina vs Mississippi trend to know
Mississippi has covered the Spread in 6 of their last 8 games at home for +3.80 Units and a 43% ROI. Find more college football betting trends for South Carolina vs Mississippi.
How to watch South Carolina vs Mississippi
| Location | Vaught-Hemingway Stadium, Oxford, MS |
| Date | Saturday, November 1, 2025 |
| Kickoff | 7:00 p.m. ET |
| TV | ESPN |
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