The Minnesota Twins are road favorites to win their series finale against the San Francisco Giants ahead of the 3:45 p.m. ET first pitch at Oracle Park on Wednesday, Sept. 23.
My top Twins vs. Giants prediction and MLB picks call for Minny to eke out the win in another low-scoring game this afternoon.
Who will win Twins vs Giants today: Twins moneyline
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Minnesota Twins starter Connor Prielipp has found a groove down the stretch, with a 2.90 xERA and 3.67 xFIP across his past five appearances, including consecutive wins.
Additionally, his 19.0% strikeout-to-walk rate during the run pops off the page.
The San Francisco Giants are also fielding a depleted lineup, with Drew Gilbert the lone hitter with at least 250 plate appearances in the majors this season.
Better yet, San Francisco is sending lefty Cesar Perdomo to the bump, and he’s been teed up for a 6.65 xERA and 6.11 xFIP across his past two starts.
I recommend the Minny moneyline to 60%.
COVERS INTEL: The Twins and Giants rank 19th and 23rd in blast-contact percentage in September, respectively, paving the way for the Under.
Twins vs Giants Over/Under pick: Under 7.5
This Under 7.5 is in play to 53.5% because the Twins are also missing multiple impact hitters, and Oracle Park ranks 26th in Baseball Savant Park Factor and 28th in home runs.
Both offenses have also been dreadful the past two weeks.
Minnesota ranks 29th in xwOBA and 26th in ISO, while San Francisco checks in 24th and 22nd, respectively.
Finally, the forecasted westerly breeze of 10 to 12 mph could gust closer to 20 mph, in from left-center field, providing an added pitching advantage this afternoon.
Twins vs Giants home run prediction: Victor Bericoto
Giants outfielder Victor Bericoto has five homers and a solid .192 ISO across 102 plate appearances, and he sports an elite 59.5% hard-hit rate against lefties. So, in a game I’m forecasting to be low-scoring, the San Francisco rookie checks out as a flier candidate to leave the yard this afternoon.
- ML/RL picks: 63-35, +31.08 units
- Over/Under picks: 36-33, +0.55 units
Twins vs Giants weather
The forecast calls for clear, sunny skies with a high near 66 degrees and potential for a sustained westerly breeze of 10 to 12 mph.
Twins vs Giants odds
- Moneyline: Twins 58% | Giants 43%
- Run line: Twins -1.5 (44%) | Giants +1.5 (57%)
- Over/Under: Over 7.5 (52%) | Under 7.5 (49%)
Twins vs Giants trend
The Giants have only won 19 of their last 50 games (-7.30 Units / -14% ROI). Find more MLB betting trends for Twins vs. Giants.
How to watch Twins vs Giants and game info
| Location | Oracle Park, San Francisco, CA |
| Date | Wednesday, September 23, 2026 |
| First pitch | 3:45 p.m. ET |
| TV | Peacock |
| Twins starting pitcher | Connor Prielipp (6-7, 4.94 ERA) |
| Giants starting pitcher | Cesar Perdomo (0-1, 3.72 ERA) |
Twins vs Giants latest injuries
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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