The San Diego Padres snapped an eight-game losing streak against the Los Angeles Dodgers on Sunday Night Baseball.
They are -115 favorites to follow it up and win their series opener against Arizona, and my Diamondbacks vs. Padres predictions and MLB picks expect them to do just that.
Who will win Diamondbacks vs Padres today: Padres moneyline (-115)
Walker Buehler was blown up in his most recent start. Otherwise, it’s been smooth sailing for him with the San Diego Padres.
He's allowed two runs or fewer in eight of his past 10, and he’s been lights out at home all season — posting a 3.13 ERA and strong 50.4 GB%.
The Arizona Diamondbacks rank dead last in OPS against righties. They’re not a team that should give Buehler much trouble.
Look for the Padres, who are up to 16th in wOBA vs. RHP over the last month, to provide run support against Brandon Pfaadt. Bet this to -125.
COVERS INTEL: Brandon Pfaadt ranks in the 20th percentile in pitcher run value and allowed four runs over three innings against San Diego back in April.
Diamondbacks vs Padres Over/Under pick: Under 8.5 (-110)
This total is a little high. Buehler hasn’t allowed more than three runs at home all year, and he has held Bottom-15 opponents in OPS to two runs or fewer in all four starts in San Diego.
The Diamondbacks are hitting .209 with a .285 wOBA against right-handed pitching over the past month. It’s tough to envision them doing much damage against Buehler in a pitcher’s park.
Although the Padres have improved offensively of late, it’s important to remember they rank dead last in runs, batting average, and OPS. They’re not a team that runs it up.
I'd play this to -120.
- ML/RL bets: 51-40, +1.00 units
- Over/Under bets: 49-39-4,, +5.39 units
Diamondbacks vs Padres weather
Temperatures in the low 70s are expected with winds blowing southeast. Boost to the pitchers.
Diamondbacks vs Padres odds
- Moneyline: Diamondbacks -105 | Padres -115
- Run line: Diamondbacks -1.5 (+160) | Padres +1.5 (-190)
- Over/Under: Over 8.5 (-115) | Under 8.5 (-105)
Diamondbacks vs Padres trend
The Padres have cashed the Under in 16 of their last 25 home games for +6.15 units and a 23% ROI. Find more MLB betting trends for Diamondbacks vs. Padres.
How to watch Diamondbacks vs Padres and game info
| Location | Petco Park, San Diego, CA |
| Date | Monday, July 6, 2026 |
| First pitch | 9:40 p.m. ET |
| TV | FS1 |
| Diamondbacks starting pitcher | Brandon Pfaadt (1-1, 5.40 ERA) |
| Padres starting pitcher | Walker Buehler (5-4, 4.61 ERA) |
Diamondbacks vs Padres latest injuries
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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