Houston welcomes Oklahoma State to town for a Week 7 Big 12 showdown, with kickoff set for 7:30 p.m. ET on FOX.
My Oklahoma State vs. Houston prediction is backing the Cougars to take care of business as short home favorites in what should be a high-scoring affair.
Find out why in my college football picks for this Oct. 17 matchup.
TOP PICK
Who will win Oklahoma State vs Houston: Houston -4.5 - top pick
Even though the Cougars have to hit the road to take on Utah next week, there's no reason they should look ahead against an Oklahoma State team sitting at 4-1, with wins over Oregon, West Virginia, and UCF.
The Cowboys are very talented offensively, led by star quarterback Drew Mestemaker, but this Houston offense is currently ranked No. 1 in quality drives.
They may not have gunslinger Conner Weigman, but the offense has kept producing.
The senior gunslinger is coming off a performance in which he carved up Kansas State on the road, throwing for 242 yards and four touchdowns while completing over 63% of his passes. The Cougars haven't even been a pass-heavy team this season, averaging well over 40 rushing attempts per game.
This offense draws a defense that faces the 10th-most rushing attempts per game this season while allowing nearly 170 rushing yards per game.
Given how efficiently the Cougars sustain drives, I lean toward the more effective offense in what should be a high-scoring affair.
Take this up to -6.5.
COVERS INTEL: Houston ranks 21st in adjusted EPA per play, while Oklahoma State ranks 27th. 
Oklahoma State vs Houston Over/Under pick: Over 62.5
This matchup has good old-fashioned Big 12 football written all over it. A massive total tells you everything you need to know about what we're in for: an offensive-heavy showdown where defense is optional, and points should come in bunches.
With how talented both offenses are, this game should look a lot like Thursday night's Colorado State vs. Texas State shootout. Both teams rank in the top 35 nationally in scoring, averaging more than 32 points per game, while each offense is racking up more than 460 yards per game.
Neither defense should have an easy time slowing these high-powered attacks, and I expect both teams to trade haymakers all night.
Combined, these teams are 7-4 to the over this season. Buckle up, because this one has all the makings of a classic Big 12 shootout.
Give me over 62.5, but I wouldn't take this number any higher!
Oklahoma State vs Houston combo
If you want to get involved in one of the week's more exciting matchups, this one has all the makings of a high-scoring shootout with multiple lead changes.
Combine all three plays above, Houston 1H -2.5, Houston -4.5, and the Over, for a payout of nearly 5.00x.
That's a fun way to sweat this one!
Oklahoma State vs Houston combo
- Houston -4.5
- Over 62.5
- Houston 1H -2.5
- 2026 picks: 44-37, +7.30 units
Oklahoma State vs Houston odds
For help understanding probabilities, see our odds calculator.
- Spread: Oklahoma State +4.5 | Houston -4.5
- Over/Under: Over 62.5 (50%) | Under 62.5 (51%)
- Moneyline: Oklahoma State 36% | Houston 64%
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Oklahoma State vs Houston weather
Houston weather should be pretty tame, with temperatures in the upper 60s and winds around 10 mph.
Nothing too concerning weather-wise for this matchup!
Check out our college football weather page for up-to-date info on every matchup.
Oklahoma State vs Houston trend to know
The Over is 5-0 in the last 5 meetings. Find more college football betting trends for Oklahoma State vs. Houston.
or our BET99 promo code COVERS99 if you're in Canada.
How to watch Oklahoma State vs Houston
| Location | TDECU Stadium, Houston, Texas |
| Date | Saturday, Oct. 17, 2026 |
| Kickoff | 7:30 p.m. ET |
| TV | FOX |
Oklahoma State vs Houston latest injuries
Check out our college football injuries page for updates on every team.
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