The Detroit Tigers will be looking to bounce back from a series opener loss to the Milwaukee Brewers as the two teams meet again tonight.
Behind Casey Mize, I’m eyeing Detroit to snatch the second game of this series in my Brewers vs. Tigers predictions.
Read more for my MLB picks for Wednesday, April 22.
Who will win Brewers vs Tigers today: Tigers moneyline (-130)
The Detroit Tigers were blown out 12-4 on Tuesday, dropping a rare home game. When playing at Comerica Park this season, the Tigers have compiled an 8-2 record at home this season. To put that dominance into perspective, they’re 12-12 overall.
AJ Hinch sends Casey Mize to the mound tonight, who has pitched to a 2.78 ERA. He’s only made one start at home, but it was impressive, allowing one earned run across 5.2 innings. The Brew Crew has faced him before, but they’ve only had 24 at-bats throughout the lineup.
On the other side, Chad Patrick takes the hill. Detroit has never faced him, but Patrick’s 0.95 ERA is a bit misleading. Firstly, he hasn’t faced a ton of difficult lineups so far, and Patrick relies heavily on contact, striking out just nine hitters in 19 innings. He also has a 3.93 FIP.
The Tigers are scoring over five runs per game at home as well.
COVERS INTEL: Mize has struck out 25 hitters in 22.2 innings of work, and he owns an impressive 1.19 WHIP. Milwaukee is 14th in the Majors in strikeouts.
Brewers vs Tigers Over/Under pick: Over 7.5 runs (-120)
While I do expect both pitchers to throw the ball well, there’s reason to believe we could see a decent amount of runs, even if they come later in the game. Patrick will come down to earth, and Detroit will respond with a win. However, the trends point to runs.
The Brew Crew has cashed the Over in three of their last four. The Tigers have also hit the Over in runs in three straight. Both of these bullpens also have ERAs over four, so once the starters have departed, there’s lots of opportunity for runs.
Plus, the Milwaukee Brewers are fourth in runs scored, and Detroit is 15th. As previously mentioned, they swing it better at Comerica, too.
- ML/RL bets: 6-4, -1.71 units
- Over/Under bets: 7-3, +3.19 units
Brewers vs Tigers odds
- Moneyline: Milwaukee +119 | Detroit -131
- Run line: Milwaukee +1.5 (-183) | Detroit -1.5 (+158)
- Over/Under: Over 7.5 (-121) | Under 7.5 (+105)
Brewers vs Tigers trend
The Detroit Tigers have hit the Game Total Over in 28 of their last 45 games at home (+13.70 Units / 28% ROI). Find more MLB betting trends for Brewers vs. Tigers.
How to watch Brewers vs Tigers and game info
| Location | Comerica Park, Detroit, MI |
| Date | Wednesday, April 22, 2026 |
| First pitch | 6:40 p.m. ET |
| TV | Brewers.TV, DSN |
| Brewers starting pitcher | Chad Patrick (1-0, 0.95 ERA) |
| Tigers starting pitcher | Casey Mize (1-1, 2.78 ERA) |
Brewers vs Tigers latest injuries
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Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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