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Best NFL Picks Today

Find the best NFL bets today - Sept. 25, 2026. Free expert and computer picks for every NFL game.

New Computer Picks powered by Odds Shark

Predicted Score

KC logo
KC
KC

26.00 @ 17.08

MIA
MIA logo
MIA

Chiefs vs Dolphins · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

KC logo
KC
KC

26.00

-10.5 -109

o45.5 -105

-575

MIA logo
MIA
MIA

17.08

+10.5 -105

u46.0 -110

+520

Carolina @ Cleveland
Matchup Stats

Predicted Score

CAR logo
CAR
CAR

20.13 @ 18.83

CLE
CLE logo
CLE

Panthers vs Browns · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

CAR logo
CAR
CAR

20.13

-2.5 -112

o41.5 -110

-142

CLE logo
CLE
CLE

18.83

+2.5 +100

u42.5 -110

+127

Tennessee @ N.Y. Giants
Matchup Stats

Predicted Score

TEN logo
TEN
TEN

15.94 @ 18.95

NYG
NYG logo
NYG

Titans vs Giants · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

TEN logo
TEN
TEN

15.94

+2.5 -105

o38.5 +100

+120

NYG logo
NYG
NYG

18.95

-2.5 -110

u38.5 -110

-130

Top Projection Jameis Winston o6.5 Rushing Yards (-110)
o5.5-110
New England @ Jacksonville
Matchup Stats

Predicted Score

NE logo
NE
NE

22.05 @ 23.69

JAC
JAC logo
JAC

Patriots vs Jaguars · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

NE logo
NE
NE

22.05

+3.0 -115

o45.5 -113

+132

JAC logo
JAC
JAC

23.69

-3.0 -105

u46.5 -115

-150

Top Projection Brenton Strange o25.5 Receiving Yards (-116)
o25.5-116
L.A. Chargers @ Buffalo
Matchup Stats

Predicted Score

LAC logo
LAC
LAC

20.83 @ 26.46

BUF
BUF logo
BUF

Chargers vs Bills · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

LAC logo
LAC
LAC

20.83

+7.5 -115

o50.0 -110

+295

BUF logo
BUF
BUF

26.46

-7.5 +100

u50.5 -115

-310

Top Projection Omarion Hampton o60.5 Rushing Yards (-114)
o57.5-115
N.Y. Jets @ Detroit
Matchup Stats

Predicted Score

NYJ logo
NYJ
NYJ

19.37 @ 29.70

DET
DET logo
DET

Jets vs Lions · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

NYJ logo
NYJ
NYJ

19.37

+7.5 -130

o47.5 -109

+260

DET logo
DET
DET

29.70

-7.5 -115

u48.0 -110

-300

Top Projection Jared Goff o0.5 Rushing Yards (+110)
o0.5+110
Houston @ Indianapolis
Matchup Stats

Predicted Score

HOU logo
HOU
HOU

21.93 @ 22.77

IND
IND logo
IND

Texans vs Colts · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

HOU logo
HOU
HOU

21.93

-1.5 -110

o42.5 -110

-125

IND logo
IND
IND

22.77

+1.5 -105

u43.5 -115

+112

Top Projection Daniel Jones o10.5 Rushing Yards (+105)
o8.5-114
Seattle @ Washington
Matchup Stats

Predicted Score

SEA logo
SEA
SEA

23.26 @ 16.10

WAS
WAS logo
WAS

Seahawks vs Commanders · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

SEA logo
SEA
SEA

23.26

-7.5 -105

o40.5 -102

-350

WAS logo
WAS
WAS

16.10

+7.5 -106

u40.5 -109

+300

Top Projection Jacory Croskey-Merritt o40.5 Rushing Yards (-105)
o38.5-115
Cincinnati @ Pittsburgh
Matchup Stats

Predicted Score

CIN logo
CIN
CIN

24.77 @ 21.41

PIT
PIT logo
PIT

Bengals vs Steelers · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

CIN logo
CIN
CIN

24.77

-3.5 -105

o42.5 -109

-175

PIT logo
PIT
PIT

21.41

+3.5 -109

u42.5 -105

+160

Top Projection Joe Burrow o250.5 Passing Yards (-115)
o246.5-117
Arizona @ San Francisco
Matchup Stats

Predicted Score

ARI logo
ARI
ARI

20.80 @ 26.79

SF
SF logo
SF

Cardinals vs 49ers · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

ARI logo
ARI
ARI

20.80

+8.5 -110

o47.5 -115

+360

SF logo
SF
SF

26.79

-8.5 -105

u48.5 -115

-400

Top Projection Jacoby Brissett o6.5 Rushing Yards (-120)
o5.5-155
Minnesota @ Tampa Bay
Matchup Stats

Predicted Score

MIN logo
MIN
MIN

20.41 @ 21.19

TB
TB logo
TB

Vikings vs Buccaneers · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

MIN logo
MIN
MIN

20.41

-1.5 -105

o42.5 -109

-120

TB logo
TB
TB

21.19

+1.5 -109

u43.0 -115

+106

Top Projection Kyler Murray o20.5 Rushing Yards (-120)
o20.5-114
Baltimore @ Dallas
Matchup Stats

Predicted Score

BAL logo
BAL
BAL

24.86 @ 25.75

DAL
DAL logo
DAL

Ravens vs Cowboys · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

BAL logo
BAL
BAL

24.86

-3.5 +100

o53.0 -110

-170

DAL logo
DAL
DAL

25.75

+3.5 -112

u53.5 -110

+160

Top Projection Dak Prescott o264.5 Passing Yards (-115)
o260.5-110
Las Vegas @ New Orleans
Matchup Stats

Predicted Score

LV logo
LV
LV

20.80 @ 25.75

NO
NO logo
NO

Raiders vs Saints · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

LV logo
LV
LV

20.80

+3.5 -120

o43.5 -110

+154

NO logo
NO
NO

25.75

-3.5 +100

u44.0 -110

-173

Top Projection Michael Mayer Score a Touchdown (Yes: +350)
+460
L.A. Rams @ Denver
Matchup Stats

Predicted Score

LA logo
LA
LA

22.52 @ 23.10

DEN
DEN logo
DEN

Rams vs Broncos · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

LA logo
LA
LA

22.52

-1.5 -105

o43.5 -110

-126

DEN logo
DEN
DEN

23.10

+1.5 -111

u44.5 -115

+117

Top Projection Matthew Stafford Score a Touchdown (Yes: +2500)
+2500
Philadelphia @ Chicago
Matchup Stats

Predicted Score

PHI logo
PHI
PHI

22.69 @ 19.29

CHI
CHI logo
CHI

Eagles vs Bears · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

PHI logo
PHI
PHI

22.69

-4.5 -110

o41.0 -112

-225

CHI logo
CHI
CHI

19.29

+4.5 -105

u41.5 -110

+200

Top Projection Luther Burden III o32.5 Receiving Yards (-113)
o30.5-120
Kansas City Chiefs image thumbnail KC @ Miami Dolphins image thumbnail MIA Sun, Sep 27 • 1:00 PM ET
Receiving Yards
Travis Kelce logo Travis Kelce o49.5 Receiving Yards (-120)
Best Odds
Pick made: 21 hours ago
Dustin Saracini logo
Dustin Saracini
Senior Analyst

The Dolphins have had issues covering tight ends this year with George Kittle securing a touchdown and 80 yards last week, and the combo of Michael Mayer/Jack Bech hauling in nine catches for 55 yards and a score in the season opener. With the Chiefs scheming Kelce open so far this year, expect him to fly past this number, he's done so twice already.

Anytime Touchdown
Kenneth Walker III logo Kenneth Walker III Score a Touchdown (Yes: -200)
Best Odds
Pick made: 22 hours ago
Dustin Saracini logo
Dustin Saracini
Senior Analyst

Looking for a slam dunk? It's Kenneth Walker. He was denied three straight times on the 1-yard line a week ago but is in line to score at least once against one of the worst run defenses in football. With the Chiefs likely in cruise control come the second half, look for them to lean on Walker and Emmett Johnson. If you're looking for more value, the team is looking to give the latter "more snaps," which could bode well this week in the touchdown department.

View 15 Picks
Carolina Panthers image thumbnail CAR @ Cleveland Browns image thumbnail CLE Sun, Sep 27 • 1:00 PM ET
Passing Yards
Deshaun Watson logo Deshaun Watson u199.5 Passing Yards (-148)
Best Odds
Pick made: 2 hours ago
Shawn Krest logo
Shawn Krest
Betting Analyst

Watson is making his return to Cleveland in the Browns' home opener. Half of his passes in last week's win were dumpoffs. Against the Panthers' pass rush and linebackers, that could be a problem. If the fans turn on him early, he could get a quick hook. 

Anytime Touchdown
Darren Waller logo Darren Waller Score a Touchdown (Yes: +351)
Best Odds
Pick made: 2 hours ago
Shawn Krest logo
Shawn Krest
Betting Analyst

With two Panthers receivers on the injury report, Young may look to the tight end. Waller had two scores last week and would have ranked second on the team in scoring if he'd been a Panther last season. 

View 21 Picks
Tennessee Titans image thumbnail TEN @ New York Giants image thumbnail NYG Sun, Sep 27 • 1:00 PM ET
Anytime Touchdown
Elic Ayomanor logo Elic Ayomanor Score a Touchdown (Yes: +850)
Best Odds
Pick made: yesterday
Josh Inglis logo
Josh Inglis
Betting Analyst

Elic Ayomanor might be WR2 facing a Giants defense that is on a short week and dealing with cluster injuries at corner. Davante Adams did whatever he wanted on MNF because of the lack of NFL talent at corner. Ayomanor should not be longer than 5.5x. He's playing better than Calvin Ridley and is getting targeted on 20% of his routes while sitting second on the team in air-yard share at 30%. He also has all of the WR red-zone targets at three through two games, with a TD. It's a longer shot here, but certainly +EV. The only thing knocking it is a bad pass offense, but the Eagles and Jets are a lot different than the Giants, who have allowed a red-zone touchdown on all six of their opponents' trips inside the 20.

Spread
New York Giants image thumbnail NYG -5.5 (-115)
Best Odds
Pick made: 4 days ago
Neil Parker logo
Neil Parker
Betting Analyst

Grabbing this -5.5 line before Monday Night Football because I’m expecting the Giants to hang with the Los Angeles Rams in Week 2, and New York will be an even larger home favorite over Tennessee by Sunday afternoon. The Titans were only on offense for 23:35 against the Philadelphia Eagles on Sunday, and QB Cam Ward has thrown for just 6.2 yards per attempt through two weeks. Tennessee also hits the highway for the first time in 2026, and the new-look G-Men put on an offensive clinic in their season opener at MetLife Stadium. 

View 12 Picks
New England Patriots image thumbnail NE @ Jacksonville Jaguars image thumbnail JAC Sun, Sep 27 • 1:00 PM ET
Anytime Touchdown
Hunter Henry logo Hunter Henry Score a Touchdown (Yes: +252)
Best Odds
Pick made: yesterday
Josh Inglis logo
Josh Inglis
Betting Analyst

This is one of the higher +EV TD plays, per THE BLITZ projections, which have Hunter Henry at a fair price of 3.05x vs. this 3.5x bargain. I'm not going to try to figure out a muddied New England backfield, but Henry is playing 92% of the snaps, and the injury to rookie Eli Raridon could help open up some more targets. The New England wide receivers are tough to trust, with five of them splitting just 12 targets last week. Henry led the team in routes and targets last week and might be the No. 1 option in the passing game right now. TEs with this kind of route and target volume should be around 3x to score.

Rushing Yards
TreVeyon Henderson logo TreVeyon Henderson o38.5 Rushing Yards (-115)
Best Odds
Pick made: yesterday
Jason Logan logo
Jason Logan
Senior Betting Analyst

TreVeyon Henderson made his season debut for New England in Week 2, garnering 60% of snaps after his backfield mate Rhamondre Stevenson fumbled early on. Henderson finished with 16 carries for 76 yards and while the touches could be better balanced in Week 3, head coach Mike Vrabel didn’t dismiss Henderson’s involvement. With the Jaguars pass rush a problem, the New England run game needs to take heat off Maye and avoid long third downs. Jacksonville isn’t as strong versus the run, including the No. 28 rating in run stop win rate at ESPN. Measuring projections between the Pats two RBs, Henderson holds the most value. His forecasts lean toward 40+ rushing yards with some as high as 57 gains on the ground in Week 3.

View 17 Picks
Los Angeles Chargers image thumbnail LAC @ Buffalo Bills image thumbnail BUF Sun, Sep 27 • 1:00 PM ET
Spread
Los Angeles Chargers image thumbnail LAC +7.5 (-115)
Best Odds
Pick made: 40 minutes ago
Neil Parker logo
Neil Parker
Betting Analyst

With this spread above the key number of 7, I’d recommend taking the points with the Los Angeles to -120. The Bolts are in a desperation spot, and the Bills haven’t shown off on defense with the fifth-highest EPA per play allowed while also surrendering the third-highest passer rating. Additionally, the Chargers have allowed the seventh-lowest EPA per rush, and the Bills have a banged up receiving corps with both D.J. Moore (shoulder) and Keon Coleman (ankle) practicing sparingly this week. It all adds up to Bolts sustaining drives to keep this game competitive, or Los Angeles coming through late with the backdoor cover against a leaky Buffalo defense on Sunday afternoon.

Anytime Touchdown
Omarion Hampton logo Omarion Hampton Score a Touchdown (Yes: -108)
Best Odds
Pick made: an hour ago
Neil Parker logo
Neil Parker
Betting Analyst

Hampton has also rushed for 3.2 yards after contact per attempt with a third-ranked 103.8 PFF Elusive Rating while handling 66% of the team’s carries. So, with Buffalo surrendering four touchdowns to opposing running backs already, I like the go-to rusher to score for a third straight week. Hampton has handled 50% of the touches in the red zone for the Bolts and has converted both his rushes inside the 10-yard line into touchdowns, too.

View 19 Picks
New York Jets image thumbnail NYJ @ Detroit Lions image thumbnail DET Sun, Sep 27 • 1:00 PM ET
Total
New York Jets image thumbnail Detroit Lions image thumbnail o47.5 (-112)
Best Odds
Pick made: 23 hours ago
Joe Osborne logo
Joe Osborne
Senior Betting Analyst

Even the Jets should find points against a Detroit defense that’s surrendered 71 through two games. The Lions can handle the heavy lifting though. They’ve led the league in home scoring in two straight seasons, have extra rest, and pose a far tougher challenge than anything the Jets have faced so far this season. Including the playoffs, eight of Detroit’s last 10 home games cleared 47.5, averaging 58.1 combined points.

Anytime Touchdown
Garrett Wilson logo Garrett Wilson Score a Touchdown (Yes: +170)
Best Odds
Pick made: 2 days ago
Josh Inglis logo
Josh Inglis
Betting Analyst

There are a lot of Jets angles I want here. The Lions have been awful at defending the TE position early in the season, as even the Saints had TDs from Juwan Johnson and Noah Fant in Week 1. The problem is that the Jets have a four-TE rotation, with Kenyon Sadiq at 5.1x being a possibility, but I'm looking elsewhere. Adonai Mitchell (4.1x) had 12 targets last week and leads the Jets in target and air-yard share, but I don't want to get cute when Garrett Wilson is 2.5x or better. It's an indoor game with a high total, and Wilson also ranks high on the Covers Anytime TD Value Index. The Jets could put up points against this toothless defense, and a move from 2.8x last week to 2.7x this week isn't enough for the setting and matchup.

View 14 Picks
Houston Texans image thumbnail HOU @ Indianapolis Colts image thumbnail IND Sun, Sep 27 • 1:00 PM ET
Passing Yards
C.J. Stroud logo C.J. Stroud o249.5 Passing Yards (+119)
Best Odds
Pick made: 2 hours ago
Dustin Saracini logo
Dustin Saracini
Senior Analyst

The Colts' defense continues to leak, especially its secondary, which has allowed back-to-back 300-yard days from opposing quarterbacks. Stroud is off to a hot start himself, throwing for 627 across his first two games - not bad. Indy is allowing nearly 14 yards per pass completion, which should put us in a great spot to cash this come Sunday.

Anytime Touchdown
David Montgomery logo David Montgomery Score a Touchdown (Yes: +105)
Best Odds
Pick made: 3 hours ago
Dustin Saracini logo
Dustin Saracini
Senior Analyst

The Colts own one of the worst red-zone defenses in the NFL, allowing teams to score at a near-70% clip when they reach their 20. This bodes well for Montgomery, who's being used the third-most in the red zone of any other running back in football, totaling six attempts for 19 yards and two touchdowns. Suffice to say when they get down by the goalline, Montgomery is their man.

View 17 Picks
Seattle Seahawks image thumbnail SEA @ Washington Commanders image thumbnail WAS Sun, Sep 27 • 1:00 PM ET
Receiving Yards
Jaxon Smith-Njigba logo Jaxon Smith-Njigba o84.5 Receiving Yards (-115)
Best Odds
Pick made: 23 hours ago
Jason Logan logo
Jason Logan
Senior Betting Analyst

Jaxon Smith-Njigba faces a banged-up Commanders secondary running one the highest rates of zone coverage through two weeks. Washington is still trying to find its way in the new schemes of DC Daronta Jones, rating near the bottom of the league in many advanced pass defense measurements. That includes rating 30th in DVOA vs. WR1. Smith-Njigba is the top WR vs. zone coverage and projections are positive in DC, with most models coming in above 90 yards – ceiling of 115 – and my number coming out to 95+ receiving yards. 

Anytime Touchdown
Emanuel Wilson logo Emanuel Wilson Score a Touchdown (Yes: +200)
Best Odds
Pick made: yesterday
Josh Inglis logo
Josh Inglis
Betting Analyst

I got this at 3x, and even if Jadarian Price is out, this could close at 2.3x. Even if Price does play, Emanuel Wilson handled more red-zone carries last week than any other running back in football and didn't get a full workload until the second half. Another angle here is that the Seahawks want to run the ball in the red zone. Through two games with Drew Lock, Seattle has run the ball 18 times in the red zone compared to just nine dropbacks. Price is dealing with a chest injury that could keep him out of the hard-yard work in the red zone even if he dresses. Give me the 20-touch back at a long TD price in a positive-game-script matchup against a backup QB.

View 12 Picks
Cincinnati Bengals image thumbnail CIN @ Pittsburgh Steelers image thumbnail PIT Sun, Sep 27 • 1:00 PM ET
Passing Touchdowns
Joe Burrow logo Joe Burrow o1.5 Passing Touchdowns (-102)
Best Odds
Pick made: 23 hours ago
Neil Parker logo
Neil Parker
Betting Analyst

Burrow has thrown for two or more touchdowns in six of his past eight games for 18 total dating back to 2025, and the Steelers have backfield question marks. Pittsburgh cornerback Jamel Dean practiced Thursday after missing Wednesday’s session with an ankle injury, safety DeShon Elliott is on injured reserve, and Joey Porter Jr.'s status continues to be clouded by contract disputes after missing the first two weeks of the season.

Anytime Touchdown
Tee Higgins logo Tee Higgins Score a Touchdown (Yes: +181)
Best Odds
Pick made: yesterday
Neil Parker logo
Neil Parker
Betting Analyst

The Bengals haven’t looked to Higgins in the red zone yet in 2026, and I’m anticipating that to change following consecutive seasons with double-digit touchdowns. Higgins garnered 19.8% and 19% of the red-zone targets the past two years, and wide receiver Andrei Iosivas (thumb) is also out of the lineup. With Pittsburgh set to have its hands full with star wideout Ja'Marr Chase, Higgins stands to see softer coverage in Week 3, too.

View 16 Picks
Arizona Cardinals image thumbnail ARI @ San Francisco 49ers image thumbnail SF Sun, Sep 27 • 4:05 PM ET
Anytime Touchdown
Deebo Samuel Sr. logo Deebo Samuel Sr. Score a Touchdown (Yes: +181)
Best Odds
Pick made: 20 minutes ago
Geoff Clark logo
Geoff Clark
Betting Analyst

Deebo Samuel's target share should increase with the injuries to San Francisco's WR corps. Also, Deebo is used in the ground game and has 22 career rushing touchdowns in the regular season and playoffs. 

Receptions Made
Christian McCaffrey logo Christian McCaffrey o4.5 Receptions Made (-116)
Best Odds
Pick made: 39 minutes ago
Geoff Clark logo
Geoff Clark
Betting Analyst

McCaffrey has a team-high 12 targets this season and led San Francisco with 102 catches last season. It was his third season with 100+ receptions. CMC caught five passes in Week 1 and caught at least five passes in 14 of his 19 regular-season and playoff games last season.

View 15 Picks
Minnesota Vikings image thumbnail MIN @ Tampa Bay Buccaneers image thumbnail TB Sun, Sep 27 • 4:05 PM ET
Passing Yards
Kyler Murray logo Kyler Murray u199.5 Passing Yards (+114)
Best Odds
Pick made: 37 minutes ago
Dustin Saracini logo
Dustin Saracini
Senior Analyst

Murray is expected to return under center after Carson Wentz guided Minnesota to a pair of victories in his absence. Murray managed just 11 snaps in the season opener before exiting with a concussion, and his return comes against a challenging Buccaneers defense that ranks 11th in total defense. I'm giving this defense the benefit of the doubt to shut down a quarterback returning from concussion, and coming off the worst season of his career.

Anytime Touchdown
Bucky Irving logo Bucky Irving Score a Touchdown (Yes: +146)
Best Odds
Pick made: 38 minutes ago
Dustin Saracini logo
Dustin Saracini
Senior Analyst

Bucky's red-zone usage alone should make you want to invest in him to score against the Vikings. Minnesota is coughing up 100 yards per game on the ground, and when you add in Irving's volume both as a runner and pass-catcher out of the backfield, it's the perfect storm for him hitting pay dirt for the second time this season.

View 16 Picks
Baltimore Ravens image thumbnail BAL @ Dallas Cowboys image thumbnail DAL Sun, Sep 27 • 4:25 PM ET
Game Prop
Baltimore Ravens image thumbnail o27.5 Team Total (-115)
Best Odds
Pick made: 23 hours ago
Joe Osborne logo
Joe Osborne
Senior Betting Analyst

Baltimore should come out swinging after scoring just 17 against New Orleans. Dallas ranks 28th in yards allowed per rush attempt and has surrendered a league-worst 68% third-down conversion rate against the Giants and a Commanders team that lost Jayden Daniels. That’s a juicy setup for Derrick Henry and Lamar Jackson. The Ravens still rank second in yards per play, and this matchup gives them every chance to look more like the team that hung 41 on Indianapolis in Week 1.

Anytime Touchdown
Jake Ferguson logo Jake Ferguson Score a Touchdown (Yes: +265)
Best Odds
Pick made: yesterday
Josh Inglis logo
Josh Inglis
Betting Analyst

This was a tough one. I wanted Lamar Jackson, as the Cowboys are giving up the most QB rushing yards to opposing QBs by a mile, but +175 isn't a price I want to pay when it went from 3.6x to 2.85x to this week's 1.75x. It's priced in. Rashod Bateman midweek is appetizing, but I don't want to be holding a 2.75x if Zay Flowers comes back. I have to go back to Jake Ferguson at 3.65x after a cash last week and two red-zone TDs. He is still the No. 3 in the passing game, but has a prominent goal-line role with three of the team's seven RZ pass attempts to tight ends and wide receivers. Dallas had the No. 1 PROE in Week 2 at 13.8%. I'd play Ferguson to 3.40x.

View 17 Picks
Las Vegas Raiders image thumbnail LV @ New Orleans Saints image thumbnail NO Sun, Sep 27 • 4:25 PM ET
Anytime Touchdown
Devaughn Vele logo Devaughn Vele Score a Touchdown (Yes: +295)
Best Odds
Pick made: 23 hours ago
Josh Inglis logo
Josh Inglis
Betting Analyst

I have to back the arm of Tyler Shough and his league-leading passing yards, but it's not Chris Olave I want — it's Devaughn Vele and his 95% snap share and 90% route share in an indoor game. Vele is a clear No. 2 in this offense and is working with a 20% target share from a quarterback who has thrown for 250+ yards in back-to-back games despite slow first halves. The wide receiver has 16 targets over two games, turning them into 12 catches for 133 yards and a TD. He's also received at least one RZ target in both games. It's another indoor game that projects to be faster and more pass-efficient, and I'm not sure this Las Vegas offense is as strong as its numbers suggest. I got this at 3.95x and would play to 3.5x.

 

Spread
Las Vegas Raiders image thumbnail LV +3.5 (-120)
Best Odds
Pick made: 2 days ago
Jason Logan logo
Jason Logan
Senior Betting Analyst

Vegas' new defensive coordinator Rob Leonard is creating tremendous pressure with his front four (No. 1 pressure rate despite blitzing on only 22% of snaps), collecting eight sacks and 10 QB hits. The Raiders now set their sights on second-year QB Tyler Shough. His PFF profile doesn’t paint a pretty picture under pressure. As a rookie, Shough was night and day when kept clean vs. under duress, rating 27th among qualifying QBs. The 2026 season produces a similar split, rating No. 5 when clean but 18th under pressure. It just so happens an already stressed New Orleans offensive line will be without starting LT Kelvin Banks for a while due to an ankle injury in Week 2. The Saints pass protection has already allowed eight sacks and ranks 28th in pass block win rate.

View 12 Picks
Los Angeles Rams image thumbnail LA @ Denver Broncos image thumbnail DEN Sun, Sep 27 • 8:20 PM ET
Receptions Made
Jaylen Waddle logo Jaylen Waddle o4.5 Receptions Made (-137)
Best Odds
Pick made: 18 minutes ago
Joe Osborne logo
Joe Osborne
Senior Betting Analyst

The Broncos barely looked Jaylen Waddle’s way in Week 1, giving him three targets which resulted in one catch for two yards. In Week 2, they fed him 10 targets, and he responded with eight catches for 138 yards as the offense found its rhythm. Waddle will be the most competent receiver the Rams have faced up until this game and he doesn’t need another monster performance to reach a modest five catches.

Anytime Touchdown
Davante Adams logo Davante Adams Score a Touchdown (Yes: +134)
Best Odds
Pick made: 23 hours ago
Josh Inglis logo
Josh Inglis
Betting Analyst

This might seem short, but I have this fair price much closer to even money. Matthew Stafford had no interest in passing to anyone but Davante Adams last Monday, even with the injuries to Puka Nacua and Jordan Whittington, who have been DNPs early this week. Adding to the pass-catcher injuries, Colby Parkinson is dealing with a knee injury. Parkinson played 70% of the snaps in Week 2 and was used more as a blocker, which could be a downgrade for the run game. Stafford was also happy to keep passing in the second half in a game that was already over when Jaxson Dart left. Adams was a beast against a bad secondary, putting up 195 yards and two TDs on 10 targets. He has a 28% target share heading into the Sunday nighter. Adams is also arguably the best red-zone pass-catching wide receiver in football. He tied for the league lead in RZ targets last year with 32 despite playing in only 14 games. He should be even money here, and even Patrick Surtain doesn't scare me.

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Philadelphia Eagles image thumbnail PHI @ Chicago Bears image thumbnail CHI Mon, Sep 28 • 8:15 PM ET
Anytime Touchdown
Johnny Mundt logo Johnny Mundt Score a Touchdown (Yes: +685)
Best Odds
Pick made: 14 minutes ago
Josh Inglis logo
Josh Inglis
Betting Analyst

I got this at 7.85x on Friday before the injury report. Dallas Goedert is likely to miss time with what is being reported as an MCL sprain, DeVonta Smith was a DNP on Thursday, and Saquon Barkley was limited. There are some key figures of this offense missing or banged up in a matchup against the Bears, who gave up 37 points in Week 1 and are likely down to QB3 on the depth chart. Johnny Mundt is going to eat snaps with two other TEs on IR in Grant Calcaterra and Eli Stowers. Former Eagle Zach Ertz was signed this week because of the lack of depth. Mundt was targeted on three of his 19 routes against the Titans in Week 2 and could see five or six targets if things fall his way. No TE1 should be longer than 4.5x.

 

Spread
Philadelphia Eagles image thumbnail PHI -4.5 (-108)
Best Odds
Pick made: 19 hours ago
Jon Metler logo
Jon Metler
Betting Analyst

I'll be backing the Philadelphia Eagles at -4.5 in this one, as I price them closer to a 6-point favorite against the Chicago Bears. I'm not going to lie, the side I choose always comes down to the numbers, but as a football fan, I'm thrilled that my edge in the projections is with the Eagles instead of Tyson Bagent/Case Keenum and the Bears. The line has moved six points from Bears -1.5 to Eagles -4.5 following Caleb Williams' injury and the downgrade to Bagent/Keenum. But I don't think the market has adjusted enough for this specific matchup against an Eagles defense coached by Vic Fangio and loaded with playmakers. This isn't a Williams-to-Bagent/Keenum downgrade against the Tennessee Titans.

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For every matchup in an NFL season, our NFL computer produces selections for a variety of different betting angles. Our computer picks are based on a proprietary algorithm that values each team in the current week to produce moneyline, spread, and point total selections.

The table above, below the game picks, tracks our NFL computer's results over the last 100 games, outlining the record and profit for selections, based on $100 unit size. We track the profit based on both opening and closing lines for every matchup.

How to Use NFL Computer Picks

The easiest way to utilize our computer picks is to simply follow our selections for every matchup, what you'd call ailing the computer." But there are other ways to utilize our NFL computer picks, as well.

You can use our NFL computer as a jumping-off point to do more research into specific lines, cross-referencing with expert picks, which can be found above the selections for some matchups, recent NFL betting trends, and more.

As well, you can gauge the confidence of the matchup. The larger the projected score, the more confident the computer is in a specific pick.

Or, if you want to implement a system, betting only on underdogs, for example, you can look for matchups in which our computer likes the underdog to inform which picks you're going to hone in on for a given week.

We have these computer picks for every sport you're looking to wager on, as well:

Free Computer Picks by Odds Shark

Moneyline

NFL moneyline picks are the simplest way to get in on the NFL action. All you have to do is simply bet on which team you think will win the game.

For moneyline picks, the favorite is represented with a minus sign (-) in front of the odds, while the underdog has a plus (+). However, you don't get the same profit for picking an underdog compared to a favorite. If the favored team is -120, a $100 bet on them would pay out $80 in profit and $180 total, if they win the game. The underdog winning at +150 would pay out a $150 profit, $250 total.

We have a complete breakdown of how to read NFL moneyline odds for these NFL computer picks.

Spread

While moneyline picks are the simplest, picking NFL games against the spread is probably the most common wager for regular NFL bettors.

To bet an NFL spread, you wager on whether a team will win by a certain number of points or more or if they'll lose by fewer points than the spread. For example, if the spread is -6.5 for the New England Patriots, you would win the bet if they win the game by 7 points or more. Or if a team is +6.5, you're betting on if they'll win outright or lose by fewer than 6.5 points.

There is a correlation between moneyline odds and the spread, as books set these lines based on the same information.

You can read more about NFL spreads here.

Totals (Over/Under)

If you aren’t entirely sold on which NFL team will win or cover in an NFL game, you can still use our NFL computer picks to bet on the point total.

As opposed to taking a side, in total or Over/Under betting, you wager on whether both NFL teams will combine for a final score of more than (Over) or less than (Under) the total number of points set by oddsmakers.

The computer picks, and your handicapping of totals is more about how you think both teams will score points, not which team has the edge to win.

More NFL Picks & Betting Tools

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