MLB Picks

Get free expert and computer MLB picks for every game on May 21, 2026. With over 25 years of betting experience, our analysts and predictive models help you find the best value.

Cleveland Guardians logo CLE @ Detroit Tigers logo DET Thu, May 21 • 1:10 PM ET
2 Expert Picks 8 Computer Picks
Total
Cleveland Guardians logo Detroit Tigers logo u7.5 (-125)
Best Odds
Pick made: 9 hours ago
Chris Faria image
Chris Faria
Betting Analyst

Tigers starter Casey Mize has a stingy 2.43 ERA and ranks in the 85th percentile in xBA (.211).

Detroit can’t score, Mize won’t give up a ton, and both teams have bullpens with a sub-4.00 ERA. 

Moneyline
Cleveland Guardians logo CLE (+100)
Best Odds
Pick made: 9 hours ago
Chris Faria image
Chris Faria
Betting Analyst

The Tigers are missing three key players (Torres, Baez, Carpenter) and have fallen off a cliff, going 2-13 over their last 15 while scoring just 2.47 runs per game over that span.

The Guardians are hot with eight wins in their last nine and rank second in runs as well as third in OBP among all teams this month.

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Pittsburgh Pirates logo PIT @ St. Louis Cardinals logo STL Thu, May 21 • 1:15 PM ET
2 Expert Picks 10 Computer Picks
Total
Pittsburgh Pirates logo St. Louis Cardinals logo o7.5 (-110)
Best Odds
Pick made: 2 hours ago
Quinn Allen image
Quinn Allen
Betting Analyst

The Over has hit in four of the last five meetings between these clubs, and both pitchers have vulnerabilities. The Cardinals have previously hit Ashcraft well, while May is allowing hard contact at a career-worst rate. With Pittsburgh scoring 13 runs in the last two games and St. Louis’ bullpen posting a 4.53 ERA, runs should come from both sides.

Moneyline
Pittsburgh Pirates logo PIT (-125)
Best Odds
Pick made: 2 hours ago
Quinn Allen image
Quinn Allen
Betting Analyst

Pittsburgh has all the momentum after a dominant 7-0 win on Wednesday, and Braxton Ashcraft continues to impress with a strong 2.16 road ERA. While Dustin May has struggled against the Pirates lineup and owns a shaky 4.50 home ERA, Pittsburgh’s offense is producing nearly five runs per game and should stay hot in the series finale.

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New York Mets logo NYM @ Washington Nationals logo WAS Thu, May 21 • 4:05 PM ET
1 Expert Pick 10 Computer Picks
Total
New York Mets logo Washington Nationals logo u8.5 (-115)
Best Odds
Pick made: 2 hours ago
Josh Inglis image
Josh Inglis
Betting Analyst

Let’s hammer the getaway Under with the New York Mets heading to Miami on Friday and the Washington Nationals traveling to Atlanta tonight. The weather is working in the Under’s favor with 10-mph winds blowing in, 60-degree temperatures, and some projected rain in the mix. Neither team is likely eager to grind through a getaway-day game, and we could see some quick at-bats with both clubs having all of their high-leverage bullpen arms available. THE BAT also backs the Under with a fair price of -153 and just 7.56 projected runs.

Total Hits
Keibert Ruiz logo
Keibert Ruiz u0.5 Total Hits (+138)
Projection 0.68
Best Odds
Pick made: 16 minutes ago
EV Model Rating
Star rating: 3 out of 5
The leading projection system (THE BAT X) projects Keibert Ruiz in the 1st percentile as it relates to his BABIP skill.. Keibert Ruiz is projected to hit 9th on the lineup card in this game.. 28% of the time that Keibert Ruiz has started against a left-handed starter this year, he has been replaced by a pinch-hitter.. The leading projection system (THE BAT) profiles Nationals Park as the worst ballpark in the game for right-handed batting average.. Nationals Park's altitude is near sea-level, one of the lowest among all major league stadiums, which usually leads (as a rule of thumb) to lower offensive output.
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Atlanta Braves logo ATL @ Miami Marlins logo MIA Thu, May 21 • 6:40 PM ET
3 Expert Picks 10 Computer Picks
Total
Atlanta Braves logo Miami Marlins logo u7.5 (+100)
Best Odds
Pick made: 5 minutes ago
Neil Parker image
Neil Parker
Betting Analyst

Braves lefty Spender Strider has allowed a single run with a miniscule 27.3% hard-hit rate across his past two starts, and the Atlanta offense has also cooled the past two weeks with just 4.5 runs per game. So, with Miami righty Sandy Alcantara allowing two earned runs or fewer in seven of his 10 starts, I'm anticipating him doing just enough to keep this total Under the number.

Moneyline
Atlanta Braves logo ATL (-136)
Best Odds
Pick made: 34 minutes ago
Neil Parker image
Neil Parker
Betting Analyst

Braves southpaw Spencer Strider has allowed a single run while holding opposing hitters to a pedestrian 27.3% hard-hit rate across his past two starts, and I’m anticipating him keeping the good times rolling against a ho-hum Miami lineup. The Marlins rank 16th in wOBA with the ninth-highest strikeout rate against left-handed arms, and Miami also ranks 20th in both overall ISO and xwOBA over the past two weeks. Of course, Atlanta has been a force at the dish all season and ranks second in both runs per game and wOBA against righties.

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Toronto Blue Jays logo TOR @ New York Yankees logo NYY Thu, May 21 • 7:05 PM ET
2 Expert Picks 10 Computer Picks
Moneyline
Toronto Blue Jays logo TOR (+132)
Best Odds
Pick made: 30 minutes ago
Jon Metler image
Jon Metler
Betting Analyst

Braydon Fisher will serve as the opener for the Toronto Blue Jays, with Spencer Miles expected to handle the bulk of the innings afterward. At +132, I’m willing to back those two arms against the New York Yankees. I price the Blue Jays closer to +105 underdogs in this spot, which is why I’m hitting the button. Toronto is expected to stack the lineup with eight right-handed bats against Carlos Rodón, who has returned from injury but hasn’t looked sharp, posting a 5.63 ERA through his first two starts while also being limited by a low pitch count. Rodón relies heavily on a fastball-slider combination, a pitch mix that has traditionally been vulnerable to right-handed power, even when he’s at his best—and right now, he clearly isn’t. The top of Toronto’s lineup, led by George Springer and Vladimir Guerrero Jr., is also very familiar with Rodón.

 

Moneyline
New York Yankees logo NYY (-160)
Best Odds
Pick made: 12 hours ago
Aisha Quiñones image
Aisha Quiñones
Senior Publishing Editor

Carlos Rodón has some redemption on his mind after a shaky, costly return in the Subway Series for the New York Yankees. As they wrap up their current series against an AL East rival, he’ll need to capitalize on a Toronto Blue Jays lineup that’s hitting just .225 against left-handers this season. Rodón has a 2-3 record with an ERA of 4.72 and 54 strikeouts in 9 appearances against the Blue Jays in his career, but this Toronto team looks like a shell of themselves to start the season. Take the home team to best the Jays as Rodón shakes off the rust and slowly, but surely finds his rhythm again on the mound.

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Athletics Athletics logo ATH @ Los Angeles Angels logo LAA Thu, May 21 • 9:38 PM ET
4 Expert Picks 10 Computer Picks
Moneyline
Athletics Athletics logo ATH (-108)
Best Odds
Pick made: 44 minutes ago
Joe Osborne image
Joe Osborne
Senior Betting Analyst

This is a strong spot for the A’s tonight against an Angels team that’s spiraling, dropping eight of its last nine games. Jose Soriano has also come back down to earth lately, giving up 12 earned runs across his last three starts. Oakland owns a massive edge offensively right now, ranking fourth in OPS over the last two weeks while the Angels sit near the bottom of the league. LA’s bullpen has been just as ugly, ranking 29th in both ERA and FIP during that stretch.

Total
Athletics Athletics logo Los Angeles Angels logo u8.5 (-115)
Best Odds
Pick made: 1 hours ago
JD Yonke image
JD Yonke
Betting Analyst

The A's are 6-16-1 O/U in their last 23 away games and now have to face breakout ace Jose Soriano and his 2.41 ERA. Luis Severino doesn't get much publicity, but he has good stuff (107 Stuff+), is better on the road (3.56 ERA), and faces a slumping Angels lineup (54 wRC+ in May). 

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Colorado Rockies logo COL @ Arizona Diamondbacks logo AZ Thu, May 21 • 9:40 PM ET
2 Expert Picks 10 Computer Picks
Total Home Runs
Corbin Carroll logo Corbin Carroll o0.5 Total Home Runs (+445)
Best Odds
Pick made: 1 hours ago
Josh Inglis image
Josh Inglis
Betting Analyst

The Arizona Diamondbacks have a great hitting matchup today as the Colorado Rockies are rolling with call-up Zach Agnos, who hasn’t started a game this year and will likely hand things off early to a Colorado bullpen that owns the second-worst ERA over the last two weeks and ranks 28th in HR/FB rate over that stretch. Corbin Carroll got the day off yesterday, but before that, he had ripped triples in back-to-back games and, three games ago, launched a pair of home runs against the Rockies and this bullpen. It’s also nice to get a Top-10 bat sitting right at +EV with a fair price around +360. Over the last two weeks, Carroll ranks eighth in BlastContact, third in slugging, and second in ISO. On this small slate, he projects as the third-most likely player to go deep behind only Aaron Judge and Mike Trout.

Total Home Runs
Hunter Goodman logo Hunter Goodman o0.5 Total Home Runs (+447)
Best Odds
Pick made: 1 hours ago
Josh Inglis image
Josh Inglis
Betting Analyst

Hunter Goodman is just 1-for-13 in his career against Arizona’s Eduardo Rodríguez, but at this price, there is still plenty of home-run upside today. First, it’s a small slate, but Goodman just saw E-Rod in his last start and did rope a 101-mph single off him. The Rockies also put nine balls in play at 95+ mph against the lefty in that series. Goodman posted a .969 OPS during it as well, including a homer off Merrill Kelly. The right-handed bat also owns the fastest swing speed on the team over the last two weeks at 75 mph. The familiarity factor usually isn’t priced in, which gives this HR prop more expected value with a fair price around +380. The lefty starter has also pitched above both his career fly-ball and HR/FB rates, so some longball regression could finally be on the way.

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