Week 6 of the NFL season puts bettors a third of the way through, and with it comes plenty of exciting action.
The Eagles and Giants kick off the festivities on TNF, and we have more action overseas between the Broncos and Jets on Sunday morning.
The Lions vs. Chiefs will be sure to deliver the goods on SNF, while we're in for another MNF double-header to close out the slate. Here are the opening odds for Week 6.
NFL odds Week 6
| Matchup | Spread | Moneyline | Over/Under |
|---|---|---|---|
 Eaglesvs  Giants |
Giants +7.5 | Eagles -370 Giants +295 |
41.5 |
 Broncosvs  Jets |
Jets +7 | Broncos -360 Jets +290 |
43.5 |
 Brownsvs  Steelers |
Steelers -5.5 | Browns +200 Steelers -245 |
38.5 |
 Cardinalsvs  Colts |
Colts -5.5 | Cardinals +194 Colts -235 |
46.5 |
 Chargersvs  Dolphins |
Dolphins +4.5 | Chargers -245 Dolphins +200 |
45.5 |
 Ramsvs  Ravens |
Ravens +7.5 | Rams -420 Ravens +330 |
45.5 |
 Seahawksvs  Jaguars |
Jaguars -1.5 | Seahawks -108 Jaguars -108 |
44.5 |
 Cowboysvs  Panthers |
Panthers +3.5 | Cowboys -190 Panthers +160 |
48.5 |
 Patriotsvs  Saints |
Saints +3.5 | Patriots -180 Saints +154 |
46.5 |
 Titansvs  Raiders |
Raiders -5.5 | Titans +215 Raiders -260 |
41.5 |
 49ersvs  Buccaneers |
Buccaneers -2.5 | 49ers +134 Buccaneers -158 |
47.5 |
 Bengalsvs  Packers |
Packers -14.5 | Bengals +810 Packers -1350 |
43.5 |
 Lionsvs  Chiefs |
Chiefs -1.5 | Lions -104 Chiefs -112 |
49.5 |
 Billsvs  Falcons |
Falcons +4.5 | Bills -225 Falcons +188 |
50.5 |
 Bearsvs  Commanders |
Commanders -4.5 | Bears +184 Commanders -220 |
50.5 |
Lines as of 10-6
Eagles vs Giants odds (Thursday, 8:15 p.m. ET, Prime)
Opening line
- Giants +7.5
- Over/Under 41.5
- View full Eagles vs. Giants odds and matchup
- Read our Eagles vs. Giants picks and predictions (coming soon)
The Eagles don’t have to wait long to get over their first loss of the season. Philadelphia opened as a 7.5-point road favorite against the Giants, and movement in the vig indicates a potential drop to a touchdown for Thursday. The total hit the board at 41.5 points.
Also see: full Thursday Night Football odds
Broncos vs Jets odds (Sunday, 9:30 a.m., NFL Network)
Opening line
- Jets +6.5
- Over/Under 43.5
- View full Broncos vs. Jets odds and matchup
- Read our Broncos vs. Jets picks and predictions (coming soon)
The Broncos opened as short as -6.5 for this UK game, and after stunning the Eagles in Week 5, action on Denver has pushed this spread through a touchdown and all the way to -7.5 on Monday morning. The total opened at 43.5 points.
Browns vs Steelers odds (Sunday, 1:00 p.m., CBS)
Opening line
- Steelers -5.5
- Over/Under 38.5
- View full Browns vs. Steelers odds and matchup
- Read our Browns vs. Steelers picks and predictions (coming soon)
The Browns don’t get a break after traveling to London this past weekend and now hit the road to play AFC North rival Pittsburgh. The Steelers opened -5.5 and briefly dropped to -4.5 before jumping back to the original spread. This total opened at 38.5 O/U.
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Cardinals vs Colts odds (Sunday, 1:00 p.m., FOX)
Opening line
- Colts -4.5
- Over/Under 46.5
- View full Cardinals vs. Colts odds and matchup
- Read our Cardinals vs. Colts picks and predictions (coming soon)
The Colts looked very strong in Week 5 and opened as a 4.5-point home chalk against the Cardinals, with public perception pushing this spread to Indianapolis -5.5. The Over/Under total opened at 46.5, and juice on the Over is rising, implying a move to 47 O/U.
Chargers vs Dolphins odds (Sunday, 1:00 p.m., CBS)
Opening line
- Dolphins +4.5
- Over/Under 46.5
- View full Chargers vs. Dolphins odds and matchup
- Read our Chargers vs. Dolphins picks and predictions (coming soon)
The Chargers are coming off a bad loss to Washington and now travel to Miami, opening as 4.5-point road chalk vs. Miami. The vig on Bolts -4.5 is climbing, which could indicate a move to -5 later in the week. This total opened as high as 46.5 and has dropped to as low as 44.5 O/U.
Rams vs Ravens odds (Sunday, 1:00 p.m., FOX)
Opening line
- Ravens +7.5
- Over/Under 45.5
- View full Rams vs. Ravens odds and matchup
- Read our Rams vs. Ravens picks and predictions (coming soon)
A battered Baltimore roster was rolled in Week 5, and the Ravens could still be in rough shape in Week 6, most notably QB Lamar Jackson, who is still sidelined. This spread opened Rams -7 and jumped to -7.5 with early play on L.A., which is coming off a mini bye after playing last Thursday. The total opened at 45.5 points.
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Seahawks vs Jaguars odds (Sunday, 1:00 p.m., FOX)
Opening line
- Jaguars -1.5
- Over/Under 43.5
- View full Seahawks vs. Jaguars odds and matchup
- Read our Seahawks vs. Jaguars picks and predictions (coming soon)
Opening line analysis coming soon!
Cowboys vs Panthers odds (Sunday, 1:00 p.m., FOX)
Opening line
- Panthers +3.5
- Over/Under 46.5
- View full Cowboys vs. Panthers odds and matchup
- Read our Cowboys vs. Panthers picks and predictions (coming soon)
The Cowboys crushed the Jets in Week 5 and now come to Carolina as 3.5-point opening favorites. Dallas could get top WR CeeDee Lamb back in Week 6, along with starters on the offensive line. This Over/Under hit the board at 47.5 O/U and jumped to 48.5 points with early play on the Over.
Titans vs Raiders odds (Sunday, 1:00 p.m., FOX)
Opening line
- Raiders -6.5
- Over/Under 41.5
- View full Titans vs. Raiders odds and matchup
- Read our Titans vs. Raiders picks and predictions (coming soon)
The Titans were gift wrapped a Week 6 win by Arizona and now face Las Vegas, which is coming off a one-sided loss to Indianapolis. The Raiders opened as big as -6.5, but initial play on Tennessee slimmed this line to -5.5. The total opened at 41.5 and briefly dropped to 40.5 before coming back to the original number.
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Patriots vs Saints odds (Sunday, 1:00 p.m., CBS)
Opening line
- Saints +3.5
- Over/Under 45.5
- View full Patriots vs. Saints odds and matchup
- Read our Patriots vs. Saints picks and predictions (coming soon)
The Patriots are coming off a massive win at Buffalo on Sunday night and now travel to the Big Easy for a battle with the Saints. New England officially opened as 3.5-point road chalk — the first time the Pats have been road faves since 2022. This Over/Under opened at 45.5 and climbed to 46.5 O/U.
49ers vs Buccaneers odds (Sunday, 1:00 p.m., CBS)
Opening line
- Buccaneers -2.5
- Over/Under 46.5
- View full 49ers vs. Buccaneers odds and matchup
- Read our 49ers vs. Buccaneers picks and predictions (coming soon)
The 49ers have more than a few injuries to keep an eye on in Week 6, including QB Brock Purdy. Tampa Bay opened as a 2.5-point home favorite and vig on that spread is climbing, indicating a potential move to a field goal. This total opened at 46.5 and climbed to 47.5 points.
Bengals vs Packers odds (Sunday, 1:00 p.m., CBS)
Opening line
- Packers -14.5
- Over/Under 42.5
- View full Bengals vs. Packers odds and matchup
- Read our Bengals vs. Packers picks and predictions (coming soon)
The Packers are coming off a bye and opened as 14.5-point favorites hosting Cincinnati in Week 6. The Bengals are in rough shape without QB Joe Burrow and now face this Green Bay defense. The total opened at 42.5 and lifted to 43.5 points.
Lions vs Chiefs odds (Sunday, 8:20 p.m., NBC)
Opening line
- Chiefs -1.5
- Over/Under 48.5
- View full Lions vs. Chiefs odds and matchup
- Read our Lions vs. Chiefs picks and predictions (coming soon)
Opening line analysis coming soon!
Also see: full Sunday Night Football odds
Bills vs Falcons odds (Monday, 7:15 p.m., ESPN)
Opening line
- Falcons +4.5
- Over/Under 50.5
- View full Bills vs. Falcons odds and matchup
- Read our Bills vs. Falcons picks and predictions (coming soon)
The Bills are back on prime time after a stunning home loss Sunday night. Buffalo opened as a 4.5-point favorites visiting the Falcons, who are coming off a bye week. This total has fluctuated between 50.5 and 49.5 points over the past 12 hours since opening.
Also see: full Monday Night Football odds
Bears vs Commanders odds (Monday, 8:15 p.m., ABC)
Opening line
- Commanders -4.5
- Over/Under 50.5
- View full Bears vs. Commanders odds and matchup
- Read our Bears vs. Commanders picks and predictions (coming soon)
There are injuries to the Commanders’ receiving corps to keep an eye on in Week 6. Washington opened as a 4.5-point home favorite against Chicago, which is coming off a bye. This total opened at 50.5 O/U and has bounced between that number and 49.5 in the opening 12 hours of action.
Also see: full Monday Night Football odds
Best NFL bets this week
Looking for our favorite spread, total, and NFL prop bets for this week's action? Check out our best free NFL picks from the Covers staff!
Odds are correct at the time of publishing and are subject to change.
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