The New Orleans Saints head to the rainy Pacific Northwest for a date with the Seattle Seahawks at Lumen Field for Week 7's final matchup.
The Seahawks will once again be missing franchise quarterback Russell Wilson for this Monday Night Football tilt, and NFL betting lines have them installed as 4.5-point home underdogs with the Over/Under at 43.
Here are our best free Saints vs. Seahawks picks and predictions for Monday, October 25, with kickoff at 8:15 p.m. ET.
Saints vs Seahawks odds
Odds via the Covers Line, an average comprised of odds from multiple sportsbooks.
The line for this game opened with the Saints at -3.5 with the Over/Under at 44. Early money has come in on New Orleans and the Under, moving the line to -4.5 and the total to 42.5.
Use the live odds widget above to track any future line movements right up until kickoff and be sure to check out the full NFL odds before placing your bets.
Saints vs Seahawks picks
Picks made on 10/22/2021 at 5:30 p.m. ET.
Click on each pick to jump to the full analysis.
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Saints vs Seahawks game info
• Location: Lumen Field, Seattle, WA
• Date: Monday, October 25, 2021
• Time: 8:15 p.m. ET
• TV: ESPN
Saints at Seahawks betting preview
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Saints: Taysom Hill QB (Out), Michael Thomas WR (Out), Erik McCoy C (Out), Tre Smith WR (Questionable), Deonte Harris WR (Out), Ian Book QB (Out), Dwayne Washington RB (Out), Malcolm Roach DT (Out), Jalyn Holmes DL (Out), Payton Turner DE (Out).
Seahawks: Russell Wilson QB (Out), Rashaad Penny RB (Probable), Chris Carson RB (Out), Damien Lewis G (Out), Darrell Taylor DE (Out), John Reid CB (Out), Damien Lewis G (Out), Stone Forsythe OT (Out), LJ Collier DE (Out).
Find our latest NFL injury reports.
Betting trend to know
The Under is 8-2 in Seattle's last 10 games on field turf. Find more NFL betting trends for Saints vs. Seahawks.
Saints vs Seahawks predictions
Saints -4.5 (-110)
The Seahawks are 2-4 and fresh off an overtime loss in Pittsburgh, which was actually a pretty good performance considering that they were missing All-Pro quarterback Russell Wilson. Wilson will be out until at least mid-November as he recovers from finger surgery on his throwing hand. He isn't Seattle's only missing key offensive player with running back Chris Carson still on the mend with a neck injury.
New Orleans is coming off a bye and in their last game defeated Washington by a score of 33-22 in Week 5. The Saints are no strangers to key injuries themselves but have stayed competitive, going 3-2 SU and ATS to start the year.
Quarterback Jameis Winston has struggled with consistency but he's coming off a four-touchdown performance against Washington, while running back Alvin Kamara is dangerous out of the backfield.
With Geno Smith throwing the ball, Seattle will need to lean on their running game. Backup Rashaad Penny will likely return to the lineup, while last week's 100-yard rusher, Alex Collins, is trending towards playing as well after suffering a hip injury. Nonetheless, whoever is running the ball for the Seahawks will have a tough time churning out yards against a Saints defense that allows the second-fewest rushing yards per game (79) and fewest yards per carry (3.3) in the league.
Defense should be the deciding factor in this contest, with the Saints ranking third in the league in defensive DVOA according to Football Outsiders. Meanwhile, the Seahawks rank just 22nd in defensive DVOA while surrendering a league-worst 433.2 yards per game. With the Saints going 11-5 ATS in their last 16 games, back them to win and cover.
Under 42.5 (-110)
Smith played relatively mistake-free against the Steelers but he threw for just 209 yards and couldn't get the ball downfield to targets like D.K. Metcalf and Tyler Lockett. He's a limited passer and the Seahawks offensive line in front of him remains one of the worst in the league, which resulted in him being sacked five times for a loss of 44 yards.
That said, the Saints passing game hasn't exactly been airing it out either, with New Orleans ranking 31st in the league with 169.4 passing yards per game. Luckily for the Saints, they have a stingy stop-unit that ranks fourth in the league in scoring defense and seventh in the league in third-down conversion rate.
Another factor that should keep this game lower-scoring is the inclement weather expected for Monday night, with a strong chance of showers and possible heavy winds.
With the Saints going 6-2 to the Under in their last eight games overall and the Seahawks cashing the Under in their previous four contests, follow the line movement and take the Under.
Alvin Kamara Over 29.5 receiving yards (-110)
Kamara is one of the best running backs in the league, especially when it comes to being a receiving threat out of the backfield. He racked up 83 catches last season while averaging 50.4 receiving yards per game. Earlier this season, he had bizarrely been overlooked in the passing game and didn't receive a single target in the Saints' Week 4 loss to the Giants.
However, New Orleans coach Sean Payton fixed that mistake in Week 5 and Kamara snagged five catches for 51 yards on a season-high eight targets. With Seattle giving up a whopping 60 receiving yards per game to opposing backs, take the Over on Kamara's receiving yards total.
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