A fresh, shiny new NFL season is here, and already there are no shortage of injury concerns heading into the opening week.
We're tracking the latest NFL Week 1 injury updates and most pressing game-time decisions to assist with your NFL picks.
Latest NFL Week 1 injury updates
Updated at 2:30 p.m. ET on Wednesday, Sept. 9.
- Ja'Marr Chase and Tee Higgins expected to practice and play: Chase went down with what at first appeared to be a devastating knee injury toward the end of training camp. But regular breathing soon resumed for all involved, and he seems to be functioning just fine after practicing earlier this week. Both Chase and Higgins, who was navigating a heel issue, are trending toward playing.
- Malik Nabers seems ready: A knee injury cut Nabers' season short last year. Giants head coach John Harbaugh wouldn't fully commit to playing him in Week 1, but said "I think he's ready to go." He practiced in full on Wednesday.
- Jonathan Brooks is limited: Brooks has been trying to put a groin issue behind him, but he's still practicing in a limited capacity. An absence or limitation this week would lead to more opportunities for Chuba Hubbard.
Who will play in NFL Week 1?
Here are the latest updates on the most critical injury situations prior to Week 1.
| Game | Player(s) / unit | Status | Latest update |
|---|---|---|---|
 Patriots vs  Seahawks |
TreVeyon Henderson |
🔴 Out | Henderson is still suffering from an ankle injury and didn't practice all week. He could be uncertain for Week 2 as well, and Rhamondre Stevenson is set to get more work. |
| Patriots vs Seahawks |
Nick Emmanwori |
🟡 Questionable | The safety has been dealing with a hamstring issue, and his potential absence could free up space for Stevenson. |
 49ers vs  Rams |
George Kittle |
🟡 Limited | Kittle has been practicing, albeit in a limited capacity, and seems like he's trending toward making his return from an Achilles injury. |
| 49ers vs Rams |
Aaron Donald |
🔴 Out | Donald didn't travel with the team, and he's still working on getting back into game shape. |
| 49ers vs Rams |
Myles Garrett |
🟢 DNP | Garrett didn't practice on Tuesday while nursing a knee issue. But there seems to be little concern, with head coach Sean McVay saying he expects the star pass-rusher to play. |
 Bears vs  Panthers |
Rome Odunze |
🟡 DNP | Odunze suffered a leg injury last week and hasn't practiced since. |
| Bears vs Panthers |
Jonathan Brooks |
🟡 Limited | Brooks appears likely to play after logging a limited practice session, but his situation is one worth monitoring. |
 Dolphins vs  Raiders |
Ashton Jeanty |
🟢 Expected to practice | Jeanty has been managing an ankle problem since Aug. 23, but he's expected to practice on Wednesday, putting him on track to play. |
 Cardinals vs  Chargers |
Jeremiyah Love |
🟢 Expected to practice | Love suffered a high ankle sprain early in the preseason. But Cardinals head coach Mike LaFleur feels good about his chances of playing and said he's "progressing well." |
 Falcons vs  Steelers |
Michael Penix Jr. |
🔴 Out | Tua Tagovailoa has already been named the starter, but Penix will be inactive altogether while recovering from his knee injury. Cooper Rush will be the QB2. |
 Broncos vs  Chiefs |
Patrick Mahomes |
🟢 Expected to practice | For a long while it's looked like Mahomes would play in Week 1, and head coach Andy Reid said "there's a good chance." |
 Buccaneers vs  Bengals |
Ja'Marr Chase and Tee Higgins |
🟢 Expected to play | Both star Bengals receivers are expected to play, and that's especially a relief regarding Chase, whose knee injury looked severe initially. |
 Cowboys vs  Giants |
Malik Nabers |
🟢 Expected to play | The stud wide receiver practiced in full on Wednesday, and he seems set to return from his knee issue. |
