NFL Week 1 Injury Updates: Who's In, Who's Out

Sean Tomlinson - Betting Analyst at Covers.com
Sean Tomlinson • Betting Analyst 16+ years betting experience
Updated: Sep 13, 2026 , 06:58 PM ET • 4 min read

We're providing the latest NFL Week 1 injury updates and tracking the most pressing injuries of the week, and who could be sitting out.

Malik Nabers New York Giants NFL Week 1 injuries
Photo By - Reuters Connect. New York Giants wide receiver Malik Nabers looks on.

A fresh, shiny new NFL season is here, and the first jam-packed Sunday is upon us, and it comes with no shortage of injury concerns already.

We're tracking the latest NFL Week 1 injury updates and most pressing game-time decisions to assist with your NFL picks.

Latest NFL Week 1 injury updates

Updated at 6:56 p.m. ET on Sunday, Sept. 13.

  • Malik Nabers active for Sunday Night Football: A knee injury cut Nabers' season short last year. Giants head coach John Harbaugh wouldn't fully commit to playing him in Week 1, but said "I think he's ready to go" earlier in the week. He practiced in full all week and was ultimately given the green light after testing his knee this afternoon. 
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Who will play in NFL Week 1?

Here are the latest updates on the most critical injury situations for Week 1.

Game Player(s) Status Latest update
Cardinals Cardinals vs Chargers Chargers Cardinals Jeremiyah Love 🟢 Active Love suffered a high ankle sprain early in the preseason. But the reports about his availability throughout the week were progressively encouraging, and the highly touted rookie is ready to roll.
Broncos Broncos vs Chiefs Chiefs Chiefs Patrick Mahomes 🟢 Expected to practice For a long while it's looked like Mahomes would play in Week 1, and head coach Andy Reid said "there's a good chance." He's been practicing in full all week too, so while there's no concrete word yet, Mahomes being under center seems highly likely.
Cowboys Cowboys vs Giants Giants Giants Malik Nabers 🟢 Active After uncertainty swirled around the receiver and his knee, he was officially named active about 90 minutes before game time.

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Sean Tomlinson - Covers
Betting Analyst

Sean Tomlinson has been navigating the sports media landscape since 2009, officially joining Sportsbook Review in 2021. Over the years, his commentary has been cited by major outlets such as The New York Times and Forbes, and he has regularly discussed his NFL insight as a guest on TSN 1050 and The Fan 590. An active bettor who places wagers on a daily basis, Sean spreads his action across several platforms, consistently favoring FanDuel and bet365 for their user-friendly interfaces. His primary handicapping focus centers on the NFL, MLB, and Formula 1, with a heavy emphasis on locating high-value prop opportunities. Sean maintains a keen interest in political prediction markets too, closely monitoring candidate odds throughout primary runs and general election cycles. He views sports betting as an interactive lens for deeper analysis, applying that exact philosophy to his editorial work. He holds a degree in media studies from the University of Guelph-Humber—a background that previously led to editorial roles at Bleacher Report and theScore.

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