The red-hot Los Angeles Rams head to Charlotte to face the Carolina Panthers this afternoon.
L.A. is atop every power ranking, and my Rams vs. Panthers predictions and NFL picks expect another dominant performance from Sean McVay's squad in this Week 13 clash.
Rams vs Panthers prediction
Rams vs Panthers Best bet: Rams -10.5 (-106)
The Los Angeles Rams are 6-0 straight up and 5-1 against the spread in their last six games. Four of their victories during that span came by 14+ points, showing that they can win with a margin.
Meanwhile, the Carolina Panthers have dropped three of their last five games by double digits.
It seems like every year, Bryce Young has a few games where he looks like the franchise quarterback he was drafted to be. However, most of the time he plays like trash.
He had an incredible 448-yard performance against the Falcons in Week 11 and then threw for 169 yards with two picks last week against a bad 49ers defense.
Young has thrown for less than 200 yards in nine of 11 games this year, and L.A. ranks second in defensive dropback EPA while allowing just 5.8 yards per pass attempt.
The Rams are also rolling on offense with weapons like Puka Nacua, Davante Adams, and Kyren Williams surrounding MVP favorite Matthew Stafford.
They should move the ball against a Panthers defense that is 24th in the league in EPA. Especially with corner Jaycee Horn and linebacker Christian Rozeboom out with injuries, and safety Tre'Von Moehrig suspended.
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Rams vs Panthers same-game parlay
Since I'm expecting L.A. to cover this spread, it stands to reason that we'll get a passing game script from Carolina. With Tetairoa McMillan the only competent Carolina pass catcher, there will be a lot of throws in his direction.
The rookie leads Carolina in targets (96), receptions (56), and receiving yards (783). While the Rams are in the Top 10 in most defensive categories, they rank a modest 17th in DVOA against No. 1 wide receivers.
Davante Adams has reeled in 5+ receptions in four of his last five games. In the one game where he went below that number he was still targeted eight times, so the volume was there. He should take advantage of a depleted Carolina secondary.
Rams vs Panthers SGP
- Rams -10.5
- Tetairoa McMillan Over 56.5 receiving yards
- Davante Adams Over 4.5 receptions
Our big-ticket SGP: Slow start!
It's tough for West Coast teams to make the trip across the country for a 1:00 p.m. ET kickoff. We could see a slow start from the Rams' offense, which could lead to the first-quarter Under cashing.
Rams vs Panthers SGP
- Rams -10.5
- Tetairoa McMillan Over 56.5 receiving yards
- Davante Adams Over 4.5 receptions
- First quarter Under 8.5
Rams vs Panthers game predictions
Rams vs Panthers moneyline prediction
The Rams are the Super Bowl favorites and lead the NFL in DVOA. The Panthers are 27th in the league in DVOA and have struggled against teams with winning records. L.A. is a -670 favorite on the moneyline for good reason and should win.
Rams vs Panthers spread prediction
With the Rams consistently winning by a margin and Carolina getting hammered by the 49ers, Saints, and Bills in the last month, I'm laying the points with L.A. That said, I'd consider paying the vig to get the Rams below that key number of 10.
Rams vs Panthers Over/Under prediction
The Rams lead the league in defensive EPA and points per game allowed (16.3). Meanwhile, Carolina is just 28th in the NFL in scoring (18.0 ppg) but is a respectable 13th in scoring defense (22.4 ppg).
The Under has gone 8-3-1 in its last six games and should cash again.
Rams vs Panthers odds
- Spread: Rams -10.5 | Panthers +10.5
- Moneyline: Rams -670 | Panthers +490
- Over/Under: Over 45.5 | Under 45.5
More NFL picks and odds from Covers
Rams vs Panthers trend to know
The Rams are 15-4 ATS in their last 19 games. Find more NFL betting trends for Rams vs. Panthers.
How to watch Rams vs Panthers
| Location | Bank of America Stadium, Charlotte, NC |
| Date | Sunday, November 30, 2025 |
| Kickoff | 1:00 p.m. ET |
| TV | FOX |
Rams vs Panthers latest injuries
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