My Rams vs. Broncos prediction analyzes the notable injuries for both sides and how those influence the markets, giving you my best NFL picks for Sunday, Sept. 27.
If Sean McVay and the Los Angeles Rams thought their trip to Australia was daunting, let’s see how they feel after playing in the thin air of Colorado on short rest in Week 3.
Los Angeles, which won on Monday, will have its early-season conditioning tested when it visits the Denver Broncos on Sunday Night Football. Despite that home advantage for Denver, L.A. is a slim road favorite ahead of this 8:20 p.m. ET kickoff.
TOP Pick
Rams vs Broncos prediction: Under 44.5
Big plays — and points — will be tough to come by in Colorado.
The Denver Broncos were expected to unleash quarterback Bo Nix with offensive coordinator Davis Webb taking over playcalling. Yet, we’ve seen a lot of the same from this conservative passing game.
Nix may have to shoulder the load on SNF, as running backs J.K. Dobbins and R.J. Harvey are hurting. Their health goes a long way toward determining how the Los Angeles Rams attack Nix, prompting Webb to rely on quicker and shorter looks to alleviate pressure on the passer.
The Rams have the opposite problem. Injuries are stacking up among the receiving options, leaving Los Angeles to lean on its two-headed RB monster of Kyren Williams and Blake Corum.
That pairing, and an excellent effort from L.A.’s offensive line, can dominate the ball and chew up clock. That exposes Denver’s run-stop unit, which sits among the worst in the NFL after two weeks.
COVERS INTEL: The Rams’ rushing power stems from its run-blocking schemes. The L.A. O-line ranks No. 4 in run block win rate at ESPN and No. 1 in adjusted line yards at PFF. Los Angeles is No. 2 in success rate per run entering Week 3.
Rams vs Broncos combo
Not only do we have two of the league's better defenses in a possible Super Bowl preview, but these offenses could be limited in their ability to push the ball beyond the sticks. Los Angeles will lean on a dominant ground game with injuries at receiver, and Denver needs to keep plays quick and short to protect Nix from the L.A. pass rush.
Corum is getting more and more love from McVay, and while he hasn’t received a red-zone carry, his snap share is about even with Williams. Given the Broncos' issues stopping the run, Corum cracks the end zone on Sunday night.
Matthew Stafford may not need to do much if L.A. can establish the run. He faces a stingy Denver secondary without a healthy group of receiving options, as his wide receivers and tight ends are battling injuries in Week 3. I have him projected for fewer than 240 passing yards.
Rams vs Broncos combo
- Under 44.5
- Blake Corum – Yes 1+ touchdown
- Matthew Stafford – No 250+ passing yards
Rams vs Broncos touchdown scorer: Blake Corum
Corum continues to gain McVay's trust, and his snap shares have been ticking up since the end of last season.
He almost drew a split with Williams in Week 2, playing 45% of snaps vs. New York. Despite that uptick, Corum has yet to see a red-zone carry.
That could change in Week 3. Williams remains the top option, but with RB3 Ronnie Rivers (who’s received two RZ carries) now on IR, the choices inside the 20-yard line are limited.
Corum scored six touchdowns in 2025, with five coming in the final six games of the schedule when his carries increased. His touchdown probabilities sit between 27% and 37% for SNF.
- Top picks: 5-1, +3.44 units
- Combos: 0-6, -6.00 units
Rams vs Broncos odds
For help understanding probabilities, see our odds calculator.
- Spread: Rams -2.5 | Broncos +2.5
- Over/Under: Over 44.5 (49%) | Under 44.5 (51%)
- Moneyline: Rams 57% | Broncos 43%
For the full slate of NFL matchups, check out our NFL odds board!
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Rams vs Broncos weather
The forecast for Mile High calls for cloudy skies and temperatures in the low 80s on Sunday. Winds are at 12 mph SSE with gusts hitting 22 mph, blowing corner to corner at Empower Field. Weather will have a minimal impact on the action.
Check out our NFL weather page for up-to-date info on every matchup.
Rams vs Broncos trend to know
Rams head coach Sean McVay owns a 16-27 Over/Under record in non-conference games (63% Unders) during his tenure in L.A. (since 2017). Find more NFL betting trends for Rams vs. Broncos.
How to watch Rams vs Broncos
| Location | Empower Field at Mile High, Denver, Colo. |
| Date | Sunday, Sept. 27, 2026 |
| Kickoff | 8:20 p.m. ET |
| TV | NBC |
Rams vs Broncos latest injuries
Check out our NFL injuries page for updates on every team.
Odds are correct at the time of publishing and are subject to change.
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