NFL Picks Against the Spread for Every Week 13 Game

Chris Vasile breaks down his favorite NFL picks against the spread for Week 13, including the Kansas City Chiefs and Buffalo Bills.

Chris Vasile - Betting Analyst at Covers.com
Chris Vasile • Betting Analyst
Nov 25, 2025 • 14:22 ET • 4 min read
Kansas City Chiefs NFL Patrick Mahomes
Photo By - Imagn Images. Kansas City Chiefs quarterback Patrick Mahomes (15) before an NFL game.

Week 13 is here, and it’s one of the best weeks of the entire NFL calendar.

We kick things off with a Thanksgiving triple-header on Thursday, followed by a must-see Black Friday showdown, a stacked Sunday slate, and a juicy Monday nighter.

I’m breaking down the best Week 13 NFL picks against the spread, so let’s jump right in.

Week 13 NFL picks against the spread

Matchup Pick
Packers Packers vs Lions Lions Lions (-2.5)
Chiefs Chiefs vs Cowboys Cowboys Chiefs (-3)
Bengals Bengals vs Ravens Ravens  Bengals (+7)
Bears Bears vs Eagles Eagles Bears (+7)
Jaguars Jaguars vs Titans Titans Titans (+6.5)
Falcons Falcons vs Jets Jets Jets (+2.5)
Rams Rams vs Panthers Panthers Rams (-10.5)
Saints Saints vs Dolphins Dolphins Saints (+5.5)
Cardinals Cardinals vs Buccaneers Buccaneers Buccaneers (-3)
49ers 49ers vs Browns Browns 49ers (-5.5)
Texans Texans vs Colts Colts Texans (+4.5)
Vikings Vikings vs Seahawks Seahawks Seahawks (-10.5)
Bills Bills vs Steelers Steelers Bills (-3.5)
Raiders Raiders vs Chargers Chargers Chargers (-9.5)
Broncos Broncos vs Commanders Commanders Broncos (-6.5)
Giants Giants vs Patriots Patriots Patriots (-7.5)

Lines courtesy of FanDuel.

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Expert Week 13 NFL ATS picks

Packers vs. Lions: Lions Lions (-2.5)

The Detroit Lions were caught in a lookahead spot last week, which is why they needed overtime vs. the Giants. On a short week, with no travel, the Lions offense should be able to outscore the Packers' inconsistent offense. 

Chiefs vs. Cowboys: Chiefs Chiefs (-3)

The Chiefs also needed OT to fend off the Colts, but now they get a favorable matchup against a piss-poor defense. I expect Mahomes to carve up the Dallas secondary with ease. 

Bengals vs. Ravens: Bengals Bengals (+7)

Joe Burrow will be back under center for the Bengals here, and that's enough to entice me to grab the +7 points in this divisional game. The Ravens were held to just 241 yards last week vs. the Jets, so covering more than a TD doesn't sound too appealing.

Bears vs. Eagles: Bears Bears (+7)

Speaking of appealing, the Bears look like a legit threat in the NFC while the Eagles appear to be going through the motions once again. Consistency is key, just like when making gravy. Take the Bears. 

Jaguars vs. Titans: Titans Titans (+6.5)

The Titans are that one team I refuse to pick against. Whether it be stupidity or other reasons that I cannot control, I don't think they should be as bad as they are. Too. Many. Points. 

Falcons vs. Jets: Jets Jets (+2.5)

Speaking of birds, the Atlanta Falcons are what you think a turkey should be, before you actually taste it. Disappointing. Injuries have played a huge part in their down season, but a win vs. the Saints doesn't make them good. I'm calling the Jets to win this outright. 

Rams vs. Panthers: Rams Rams (-10.5)

Is he good, or is he bad? That's the weekly question surrounding Bryce Young. You know who is good, tho? Matthew Stafford. He'll continue to have this Rams offense humming in a runaway victory. 

Saints vs. Dolphins: Saints Saints (+5.5)

When you have bad vs. worse, you always have to take the points, which is what I'll do here with the Saints. 

Cardinals vs. Buccaneers: Buccaneers Buccaneers (-3)

I don't think the Buccaneers are as bad as they looked last week. Baker Mayfield should be back, and I trust him more than Jacoby Brissett. 

49ers vs. Browns: 49ers 49ers (-5.5)

Shedeur Sanders got his first win as an NFL starter last week, and this week, he'll suffer his first loss. If Brock Purdy can protect the ball, this game shouldn't be close. 


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Texans vs. Colts: Texans Texans (+4.5)

Maybe I underestimated the Texans' defense, which was nails last week against the Bills. I say they give Daniel Jones fits here while slowing down Jonathan Taylor. Grab the points in this divisional clash. 

Vikings vs. Seahawks: Seahawks Seahawks (-10.5)

I'm out on the Vikings as a team, and with good reason. J.J. McCarthy will likely miss this game with a concussion, which means Max Brosmer will be tossed into the fire. Take the Seahawks on the Alt line of -16.5 at +178.

Bills vs. Steelers: Bills Bills (-3.5)

Whether it's Aaron Rodgers or Mason Rudolph, I don't like the Steelers' chances. The Bills' offensive line was bullied to a man last week, but I think they'll be much better in this spot. Take the better offense. 

Raiders vs. Chargers: Chargers Chargers (-9.5)

I will not back the Raiders the rest of the year. This is my promise to you. 

Broncos vs. Commanders: Broncos Broncos (-6.5)

Both teams are coming off a bye, but one is playing for a division title, while the other is playing out the string. If the Broncos are anything less than 100% focused on this one, I would be shocked. 

Giants vs. Patriots: Patriots Patriots (-7.5)

In Drake Maye we trust. 

My NFL ATS record is 87-90-1 this season for -9 units.

Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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Chris Vasile Covers.com
Betting Analyst

Chris Vasile has been in the betting industry for well over a decade, honing his craft as a writer, editor, and handicapper. Chris has contributed betting and non-betting content for online publications such as ProSportsDaily and The Hockey Writers, in addition to Covers. With a keen interest in soccer, Chris has been featured on Covers' 'Before You Bet', BetMGM Network, and SportsGrid. He also runs his own YouTube channel — Game Day Wagers.

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