The playoffs have finally arrived, and we’re locked and loaded with six matchups spanning Saturday through Monday.
Headlined by the Houston Texans spoiling the party in Steeltown, here are my favorite moneyline NFL picks for every game during Wild Card Weekend.
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Wild Card Weekend moneyline picks
| Matchup | Pick |
|---|---|
 Rams vs  Panthers |
-650 |
 Packers vs  Bears |
-116 |
 Bills vs  Jaguars |
-110 |
 49ers vs  Eagles |
-225 |
 Chargers vs  Patriots |
-198 |
 Texans vs  Steelers |
-174 |
Lines courtesy of FanDuel.
Expert Wild Card Weekend moneyline picks
Rams vs Panthers: Rams (-650)
Although Carolina upset Los Angeles 31–28 in Week 13, an uncharacteristic game from Matthew Stafford saw the Rams’ gunslinger turn the ball over three times, including the Panthers offense going a ridiculous 3-for-3 on fourth down.
The Rams’ scoring unit remains elite across all key metrics, finishing the year first in points per game (30.5), and Sean McVay won’t allow a repeat stumble at Bank of America Stadium.
Read our full Rams vs. Panthers predictions.
Packers vs Bears: Packers (-116)
It’s hard to overlook Jordan Love’s playoff experience compared with Caleb Williams.
If it weren’t for Chicago’s miraculous Week 16 comeback over Green Bay, the Packers would be slight favorites — but I’ll take the Packers, who remain stronger on defense despite injuries.
Chicago’s stock is at an all-time high right now, making this a perfect time to push back against the public.
Bills vs Jaguars: Bills (-110)
Get ready for a battle between the No. 1 rushing offense and the No. 1 rushing defense.
While it’s hard to ignore Josh Allen’s mastery under center, Jacksonville has won nine of its last 10 games, and Liam Coen has Trevor Lawrence playing the best football of his career.
With Buffalo remaining banged up on D, I’ll side with the home team to open the Sunday slate.
49ers vs Eagles: Eagles (-225)
San Francisco has been an incredible story, and Kyle Shanahan deserves a ton of credit for getting this injury-riddled roster to the postseason... but last week’s loss to Seattle hurt in more ways than one.
Not only did that home loss to Seattle cost them the No. 1 seed in the NFC, but starting linebacker Dee Winters is now listed as questionable after leaving the game with an ankle injury, while Tatum Bethune is done for the rest of the season (groin).
Already without All-Pro stars Fred Warner and Nick Bosa, a fully healthy Eagles team will send the 49ers packing on Saturday.
Chargers vs Patriots: Patriots (-198)
Considering the state of the Chargers’ offensive line, this isn’t a team that can afford to play from behind in Foxborough.
As good as the Chargers’ defense has been this season, Drake Maye is going to move the ball at some point, and the Patriots faithful will be rearing to go for their first home playoff game since 2019.
Bank on Justin Herbert remaining winless in the postseason.
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Texans vs Steelers: Texans (-174)
While Houston enters the postseason on the back of nine straight wins, the Steelers have essentially backed their way into the playoffs, barely squeaking by in Week 18 following a missed field goal at the buzzer by Baltimore kicker Tyler Loop.
Pittsburgh’s sluggish offense remains a tough watch, and the Houston Texans’ vaunted pass rush will make life miserable for Aaron Rodgers.
Mike Tomlin has lost six straight playoff games dating back a decade, and another quick exit is in store on Monday.
