The biggest mismatch of the Wild Card Round kick-starts the action with the Los Angeles Rams heading to Bank of America Stadium to take on the Carolina Panthers on Saturday, January 10.
I’m not expecting much roar from Carolina, and my Rams vs. Panthers predictions and NFL picks are calling for Los Angeles to cover the number while punching a ticket to the divisional round.
Rams vs Panthers prediction
Rams vs Panthers Best bet: Rams -10.5 (-112)
There’s a mismatch on both sides of the ball in this Wild Card bout, and the Carolina Panthers aren’t going to keep pace with — or cover the spread — against the Los Angeles Rams on Saturday.
Carolina finished 25th in DVOA with a minus-69 point differential, and Los Angeles ranked second with a plus-172 mark, after all.
I also value the postseason experience of Rams MVP candidate Matthew Stafford, while Panthers QB Bryce Young is making his first playoff start against the fourth-ranked defense in DVOA and finished 20 spots below Stafford in EPA+CPOE composite during the regular season.
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Rams vs Panthers same-game parlay
In addition to the weather forecast looking unfavorable, the Los Angeles defense is going to give the Carolina offense too much trouble for the Black Cats to put up enough points for this Over to hit.
Los Angeles generated pressure at the seventh-highest clip during the regular season despite blitzing at the second-lowest rate, so I expect the Rams to make life uncomfortable for Young with the Panthers ranking 30th in pass block win rate.
Turning to Los Angeles running back Kyren Williams, while he’s failed to find the end zone in three consecutive games, I’m anticipating him returning to pay dirt Saturday.
The Panthers allowed 10 touchdowns to opposing rushers across their final seven games, and Williams scored in six of seven games before the highlighted three-week drought.
Rams vs Panthers SGP
- Rams -10.5
- Under 46.5
- Kyren Williams anytime touchdown
Our big-ticket SGP: Rams run rampant
The Rams have been giving No. 2 running back Blake Corum more and more work down the stretch, and he’s piled up an average of 67.5 rushing yards per game while scoring in four of six since Week 13.
Rams vs Panthers SGP
- Rams -10.5
- Kyren Williams anytime touchdown
- Blake Corum anytime touchdown
- Blake Corum Over 40.5 rushing yards
Rams vs Panthers odds
- Spread: Rams -10.5 | Panthers +10.5
- Moneyline: Rams -700 | Panthers +475
- Over/Under: Over 46.5 | Under 46.5
More NFL picks and odds from Covers
Rams vs Panthers trend to know
The Los Angeles Rams have covered the spread in 17 of their last 22 games (+11.45 Units / 47% ROI). Find more NFL betting trends for Rams vs. Panthers.
How to watch Rams vs Panthers
| Location | Bank of America Stadium, Charlotte, NC |
| Date | Saturday, January 10, 2026 |
| Kickoff | 4:30 p.m. ET |
| TV | FOX |
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