The Buffalo Bills host the New York Giants to kick off the preseason at Highmark Stadium on Saturday afternoon.
The preseason hasn't been kind to the Giants in recent years — not that the regular season has — and my Giants vs. Bills predictions expect that to continue.
Find out why in my NFL picks for Saturday, August 9.
Giants vs Bills prediction
Giants vs Bills Best bet: Bills -3 (-110 at bet365)
The New York Giants went 1-2 in each of the last three preseasons, including scoring a total of 30 points in three games last year. The Buffalo Bills, meanwhile, are 16-11 in eight years under Sean McDermott as they've become a top team in the AFC.
Buffalo is going to get its first look at Joey Bosa on defense after the big addition in free agency, and there are plenty of other players down the depth chart looking to make their mark.
It’s also worth taking a look at the line movement for preseason action. The Bills opened as slight -1.5-point favorites and even moved as far as +3.5 underdogs on Thursday, but they're back to being favored by a field goal at home.
The Bills simply outclass the Giants overall, and that trickles all the way down to the backups. Give the edge to the home squad and the better team here with the Bills in Buffalo.
Giants vs Bills odds
Giants vs Bills live odds
Giants vs Bills opening odds
- Spread: Giants -1 | Bills +1
- Moneyline: Giants -115 | Bills -105
- Over/Under: Over 36.5 | Under 36.5
How to watch Giants vs Bills
| Location: | Highmark Stadium, Orchard Park, NY |
| Date: | Saturday, August 9, 2025 |
| Kickoff: | 1:00 p.m. ET |
| TV: | NFL Network |
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