Patrick Mahomes has never started a season 0-3, and his Kansas City Chiefs will look to avoid a first against the New York Giants tonight on Sunday Night Football.
Below, we dig into our fully-loaded slate of Chiefs vs. Giants predictions for this prime-time matchup on Sunday, September 21.
Chiefs vs Giants SNF predictions
- Chiefs -5.5 (-120 at FanDuel)
- Under 44.5 (-110 at FanDuel)
- Mahomes TD (+400 at FanDuel)
- Robinson o4.5 rec (-160 at FanDuel)
Chiefs vs Giants SNF best bets
Chiefs -5.5
Jason Logan thinks the Chiefs will walk out of the Big Apple with a win.
"The Chiefs are being discounted for losing to two very good opponents. Steve Spagnoulo’s defense has the upper hand on former coworker Mike Kafka’s questionable play-calling."
Under 44.5
JLo also thinks that Chiefs' D will keep this total low.
"The Giants were able to open up against a dreadful Dallas defense last weekend. Kansas City is a different beast. They bring blitz and run more man-to-man coverage, which is a sore spot for Russell Wilson."
Chiefs vs Giants SNF TD picks
Patrick Mahomes
Chris Faria backs Patrick Mahomes to find the end zone for the third straight game.
"The New York Giants own the worst rushing defense in the NFL this year (177.5 yards per game), so I suspect we’ll see Mahomes find paydirt again in Week 3."
Chiefs vs Giants SNF props
Wan'Dale Robinson Over 4.5 catches
Ryan Gilbert believes Wan'Dale Robinson is in for another big day at the office.
"This line of 4.5 catches is a bit confusing. He’s easily reached it in each of the first two games, and the Kansas City Chiefs have allowed five catches to a total of four receivers (Keenan Allen, Ladd McConkey, Quentin Johnston, and A.J. Brown) through two weeks."
Chiefs vs Giants odds
Chiefs vs Giants game info
| Location: | Stadium, City, State |
| Date: | Sunday, September 21-2025 |
| Kickoff: | 8:20 p.m. ET |
| TV: | NBC |
Chiefs vs Giants latest injuries
Chiefs vs Giants weather
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