The Houston Texans are trying their hardest to get back in the playoff race, but things will get more difficult when the Buffalo Bills come to town for Thursday Night Football.
My Bills vs. Texans anytime touchdown picks target a pair of running backs to find the end zone in this November 20 matchup.
For more NFL picks, read our Bills vs. Texans predictions!
Bills anytime touchdown pick
James Cook (-120 at bet365)
James Cook ain't cooking like he did in 2024, but he still has eight total touchdowns through 10 games.
We're most likely getting a price this good because of how well the Houston Texans have played on defense, but the Buffalo Bills have the personnel to break them down.
Travis Etienne found paydirt back in Week 10 against Houston on 16 attempts, and I think we'll see the Bills wear down the Texans' D in a similar fashion, with plenty of runs eating up clock.
Once in the red zone, Cook leads the Bills in carries with 30, putting him in the Top 10 in that category. His volume alone makes this a valuable bet, especially at this price.
Buffalo's RB1 has also registered 21 receptions, making him a threat in the air as well. Let James cook!
Texans anytime touchdown pick
Woody Marks (+125 at bet365)
Getting plus money on any running back to score against the Bills at this point is a gift. Buffalo has been getting eaten alive in the trenches, surrendering over 120 yards per game on the ground against RBs.
Those backs have been finding success in the red zone, too, with 14 rushing scores against the Bills. They simply have had no answers to fix this issue.
Woody Marks has been fighting for RB1 with Nick Chubb over the last several weeks, with both backs rushing 99 times each. However, it seems the Texans' coaching staff has finally given in, with Woody having 32 rushes to Chubb's eight over the past two outings.
Marks' workload will give him plenty of chances to find paydirt, and there's not a damn thing Buffalo can do about it.
One quick note: Buffalo has given up at least two TDs to running backs in back-to-back outings, so a quarter-unit on Chubb +500 is also a strong lean.
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