A lot of teams in the AFC will be paying close attention to tonight's matchup, as an Indianapolis Colts loss would provide playoff berths for several teams.
That loss could come at the hands of the San Francisco 49ers, who are looking to stay afloat atop the ultra-competitive NFC West.
With so much at stake in the finale of Week 16, this game is a must-watch for NFL fans across the league, and we tell you all the ways you can tune in! Whether it's streaming on legal sports betting sites or listening to your radio, there are endless options to ensure you don't miss a snap.
Once you find a way to tune in, check out our 49ers vs. Colts predictions so you can get in on the action!
49ers vs Colts game info
| Location | Lucas Oil Stadium, Indianapolis, IN |
| Date | Monday, December 22, 2025 |
| Kickoff | 8:15 p.m. ET |
| TV | ESPN |
Bet with Caesars Sportsbook and get live streaming for 49ers vs Colts
Bet $1, get 20 100% boosts
Code: COVERS20X
Caesars Sportsbook pioneered live streaming NFL games in December 2022 by launching its "Watch & Bet" feature for both regular-season and playoff matchups. Since then, Caesars has improved the experience with "BetVision," a built-in viewing tool that lets you watch games, check live odds, place bets, and manage your bet slip all in one place.
To stream 49ers vs. Colts, just open the Caesars app and select the matchup. You’ll be able to watch the game live, see updated odds, and make in-game bets as the action happens.
Read our detailed Caesars Sportsbook review to learn more about the site's NFL betting options, key features, customer service, and withdrawal options.
Bet with bet365 and get live streaming for 49ers vs Colts
$1,000 First Bet Safety Net
Code: COVERS365 (Void in Ontario)
Bet $10, Get $50
Code: COVERS365 (Void in Ontario)
Canadian users can count on bet365 as one of the best platforms for live streaming NFL and NHL games in real time. When you choose a game in the bet365 app, you can watch the action live and place bets at the same time.
To watch NFL live streams, you need to be a registered user in Canada, have money in your account, and have placed a bet in the last 24 hours.
Read our detailed bet365 review to learn more about the site's options for betting on the NFL, plus other key features.
Bet with BET99 and get live streaming for 49ers vs Colts
$800 First Bet Encore
Code: COVERSBONUS
BET99 now gives you a full betting and viewing experience with BetVision, launched just in time for the 2025 NFL season. This interactive feature lets you stream games live, see real-time stats, and place bets, all on one screen.
To get started, log in to your BET99 account and go to the “Live In-Game” section. Look for events with a play icon — those are available to stream live. To watch, you’ll need to place either a pre-game or in-game bet on that event. Additional terms and conditions may apply.
Read our detailed BET99 review to discover why the sportsbook has become a fan favorite among Canadian bettors.
📺 How to watch 49ers vs Colts on TV
ESPN has exclusive television coverage of this late-night Monday Night Football tilt. As always, Joe Buck will be the play-by-play announcer with Troy Aikman as an analyst and Erin Andrews, Lisa Salters, and Laura Rutledge as the sideline reporters.
If you don't have a cable subscription, ESPN now offers ESPN Unlimited, a direct-to-consumer streaming tier with full access to ESPN’s linear networks like ESPN, ESPN2, ESPNU, ESPN on ABC, and many more. The platform serves up more than 47,000 live events per year, including MNF.
📻 How to listen to 49ers vs Colts
For those who'd rather listen to the action, tune into the national feeds provided by Westwood One Sports and SiriusXM NFL Radio (Channel 88).
Home fans who want to hear all the action on the radio can do so at WIBC HD 2 (107.5 or 93.5 FM). San Francisco fans can catch the game on KSFO (810 AM). The Bone (107.7 FM) and the 49ers radio network.
49ers vs Colts predictions for Monday Night Football
- 49ers vs Colts predictions
- 49ers vs Colts props
- 49ers vs Colts same game parlay picks
- 49ers vs Colts anytime touchdown scorer picks
- 49ers vs Colts computer picks
- Philip Rivers odds and props
- Free NFL picks and predictions
🏈 What is Monday Night Football?
Monday Night Football has long been a crown jewel of the NFL schedule, delivering a prime-time stage that caps off each week of action. The tradition began in September 1970 when ABC introduced the concept of a nationally televised game on Monday night, instantly changing the way fans experienced professional football. It was designed to bring the game to a broader audience and quickly became a cultural phenomenon.
Over the decades, Monday Night Football has showcased unforgettable performances and legendary matchups, turning weeknights into can’t-miss events. In 2006, ESPN took over as the exclusive broadcaster, carrying the tradition into a new era and ensuring millions of fans could tune in. Today, Monday Night Football remains a centerpiece of the NFL’s programming, blending star power, high stakes, and the unique electricity of football under the lights.
📆 Monday Night Football schedule
| Date | Matchup | Time |
|---|---|---|
| 9/8 Week 1 |
Vikings at Bears | 8:15 ESPN/ABC |
| 9/15 Week 2 |
Buccaneers at Texans | 7:00 ESPN/ABC |
| 9/15 Week 2 |
Chargers at Raiders | 10:00 ESPN |
| 9/22 Week 3 |
Lions at Ravens | 8:15 ESPN/ABC |
| 9/29 Week 4 |
Jets at Dolphins | 7:15 ESPN |
| 9/29 Week 4 |
Bengals at Broncos | 8:15 ABC |
| 10/6 Week 5 |
Chiefs at Jaguars | 8:15 ESPN/ABC |
| 10/13 Week 6 |
Bills at Falcons | 7:15 ESPN |
| 10/13 Week 6 |
Bears at Commanders | 8:15 ABC |
| 10/20 Week 7 |
Buccaneers at Lions | 7:00 ESPN/ABC |
| 10/20 Week 7 |
Texans at Seahawks | 10:00 ESPN |
| 10/28 Week 8 |
Commanders at Chiefs | 8:15 ESPN/ABC |
| 11/3 Week 9 |
Cardinals at Cowboys | 8:15 ESPN/ABC |
| 11/10 Week 10 |
Eagles at Packers | 8:15 ESPN/ABC |
| 11/17 Week 11 |
Cowboys at Raiders | 8:15 ESPN/ABC |
| 11/24 Week 12 |
Panthers at 49ers | 8:15 ESPN |
| 12/1 Week 13 |
Giants at Patriots | 8:15 ESPN |
| 12/8 Week 14 |
Eagles at Chargers | 8:15 ESPN/ABC |
| 12/15 Week 15 |
Dolphins at Steelers | 8:15 ESPN |
| 12/22 Week 16 |
49ers at Colts | 8:15 ESPN |
| 12/29 Week 17 |
Rams at Falcons | 8:15 ESPN |
| No MNF matchup for Week 18 |
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
Affiliate Disclosure: Our team of experts has thoroughly researched and handpicked each product that appears on our website. We may receive compensation if you sign up through our links.
