Monday Night Football Computer Picks: Our Best Week 16 Player Prop Projections

Our NFL player prop projections see a ton of value — and plus-money alt-total opportunities — in the Colts' passing game tonight.

Jared Hochman - Content Operations Manager at Covers.com
Jared Hochman • Content Manager
Dec 22, 2025 • 09:49 ET • 4 min read
49ers vs Colts computer picks Michael Pittman Tyler Warren
Photo By - Imagn Images. Indianapolis Colts wide receiver Michael Pittman Jr. (11) celebrates with tight end Tyler Warren (84)

The Monday Night Football matchup for Week 16 features an inter-conference matchup between the 49ers and Colts.

Our NFL player prop projections have identified the best MNF prop values for tonight, highlighted by multiple alt-total opportunities (at big plus money) for the Colts' passing game.

49ers vs Colts computer picks for Monday Night Football

49ers 49ers Colts Colts
Purdy o245.5 pass
-110
Rivers o159.5 pass
-110
McCaffrey o34.5 rec
-110
Taylor o19.5 rec
-110
Jennings o57.5 rec
-110
Pittman o30.5 rec
-110
Kittle u68.5 rec
-110
Warren o35.5 rec
-110
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49ers MNF computer picks

Brock Purdy Over 245.5 passing yards (-110)

Projection: 265.97 yards

Purdy returned from injury last week and threw for 295 yards, and we're expecting him put up a lofty total again this evening.

Bet Purdy passing yards now at bet365!

Christian McCaffrey Over 34.5 receiving yards (-110)

Projection: 47.46 yards

We're not as enthusiastic on the Over for CMC's rushing yards, but there is value in the dual-threat back going past his receiving yardage line.

Alternate-total bet
40+ yards (+120) - This prop shows strong value.

Bet McCaffrey receiving yards now at bet365!

Jauan Jennings Over 57.5 receiving yards (-110)

Projection: 59.06 yards

Our projections put Jennings just beyond his posted total for tonight's game.

Bet Jennings receiving yards now at bet365!

George Kittle Under 68.5 receiving yards (-110)

Projection: 67.8 yards

We've also got the Niners TE1 right at his yardage total, finishing just below the hook.

Bet Kittle receiving yards now at bet365!


More Monday Night Football picks from Covers


Colts MNF computer picks

Philip Rivers Over 159.5 passing yards (-110)

Projection: 246.07 yards

Rivers threw for 120 yards in his season debut last week, but we're projecting him to have a much better output tonight.

Alternate-total bet
175+ yards (+135) - This prop shows incredible value based on our projection.
200+ yards (+310) - This price has even better value.
225+ yards (+600) - This is a true ladder opportunity, as this shows the best value.

Bet Rivers passing yards now at bet365!

Jonathan Taylor Over 19.5 receiving yards (-110)

Projection: 23.79 yards

Our projections also see slight value in Taylor's rushing Over, but they find more value in taking him to surpass his receiving total.

Bet Taylor receiving yards now at bet365!

Michael Pittman Over 30.5 receiving yards (-110)

Projection: 58.49 yards

We're also seeing a ton of value in the Over for Indy's WR1, after almost topping this total last week.

Alternate-total bet
40+ yards (+160) - This prop also shows tremendous value.
50+ yards (+280) - The value on this alt-total is even better than 40+.

Bet Pittman receiving yards now at bet365!

Tyler Warren Over 35.5 receiving yards (-110)

Projection: 56.12 yards

Warren has seemingly hit the rookie wall over the last few weeks, but we're projecting him to get back to his earlier-season form tonight.

Alternate-total bet
40+ yards (+120) - The price on this prop shows phenomenal value.
50+ yards (+220) - This number is much better value.

Bet Warren receiving yards now at bet365!

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Jared Hochman Content Operations Manager at Covers.com
Content Manager

Before Jared Hochman joined the Covers team in 2020, he worked for newspaper outlets such as the Chronicle Herald and The Coast, worked in marketing for SkipTheDishes and Vivid Seats, and previously ran a magazine. A journalism graduate from the University of King's College in, Halifax, N.S., "Hoch" brings more than a decade of experience in sports betting, having worked as a freelance handicapper, making appearances on Monumental Sports Network and the Sharp 600 podcast, and now also filling in occasionally as host of Covers' NHL Puck Props. 

Awarded Covers' company MVP for 2023, Jared is an avid bettor of MLB, NFL, NHL, and NBA, while also wagering on some soccer and WNBA. His best advice for sports bettors? Price shop, which is something he does daily across 10 different sportsbook apps.

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