The Monday Night Football matchup for Week 16 features an inter-conference matchup between the 49ers and Colts.
Our NFL player prop projections have identified the best MNF prop values for tonight, highlighted by multiple alt-total opportunities (at big plus money) for the Colts' passing game.
49ers vs Colts computer picks for Monday Night Football
| Purdy o245.5 pass -110 |
Rivers o159.5 pass -110 |
| McCaffrey o34.5 rec -110 |
Taylor o19.5 rec -110 |
| Jennings o57.5 rec -110 |
Pittman o30.5 rec -110 |
| Kittle u68.5 rec -110 |
Warren o35.5 rec -110 |

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49ers MNF computer picks
Brock Purdy Over 245.5 passing yards (-110)
Projection: 265.97 yards
Purdy returned from injury last week and threw for 295 yards, and we're expecting him put up a lofty total again this evening.
Bet Purdy passing yards now at bet365!
Christian McCaffrey Over 34.5 receiving yards (-110)
Projection: 47.46 yards
We're not as enthusiastic on the Over for CMC's rushing yards, but there is value in the dual-threat back going past his receiving yardage line.
Alternate-total bet
40+ yards (+120) - This prop shows strong value.
Bet McCaffrey receiving yards now at bet365!
Jauan Jennings Over 57.5 receiving yards (-110)
Projection: 59.06 yards
Our projections put Jennings just beyond his posted total for tonight's game.
Bet Jennings receiving yards now at bet365!
George Kittle Under 68.5 receiving yards (-110)
Projection: 67.8 yards
We've also got the Niners TE1 right at his yardage total, finishing just below the hook.
Bet Kittle receiving yards now at bet365!
More Monday Night Football picks from Covers
- 49ers vs Colts predictions
- 49ers vs Colts props
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- 49ers vs Colts anytime TD picks
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Colts MNF computer picks
Philip Rivers Over 159.5 passing yards (-110)
Projection: 246.07 yards
Rivers threw for 120 yards in his season debut last week, but we're projecting him to have a much better output tonight.
Alternate-total bet
175+ yards (+135) - This prop shows incredible value based on our projection.
200+ yards (+310) - This price has even better value.
225+ yards (+600) - This is a true ladder opportunity, as this shows the best value.
Bet Rivers passing yards now at bet365!
Jonathan Taylor Over 19.5 receiving yards (-110)
Projection: 23.79 yards
Our projections also see slight value in Taylor's rushing Over, but they find more value in taking him to surpass his receiving total.
Bet Taylor receiving yards now at bet365!
Michael Pittman Over 30.5 receiving yards (-110)
Projection: 58.49 yards
We're also seeing a ton of value in the Over for Indy's WR1, after almost topping this total last week.
Alternate-total bet
40+ yards (+160) - This prop also shows tremendous value.
50+ yards (+280) - The value on this alt-total is even better than 40+.
Bet Pittman receiving yards now at bet365!
Tyler Warren Over 35.5 receiving yards (-110)
Projection: 56.12 yards
Warren has seemingly hit the rookie wall over the last few weeks, but we're projecting him to get back to his earlier-season form tonight.
Alternate-total bet
40+ yards (+120) - The price on this prop shows phenomenal value.
50+ yards (+220) - This number is much better value.
Bet Warren receiving yards now at bet365!
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