The Illinois Fighting Illini will look to pick up another Big Ten win on Saturday as they visit the Purdue Boilermakers at Ross-Ade Stadium.
Purdue has struggled to contain opposing offenses over the past two games, and I’m taking the Illini to cover in my Illinois vs. Purdue predictions.
Keep reading to get the full scoop on this Week 6 matchup in my free college football picks for October 4.
Illinois vs Purdue prediction
Illinois vs Purdue best bet: Illinois -9.5 (-118)
Ever since the Purdue schedule took a turn for the worse, the Boilermakers have had a tough time competing.
A 33-17 loss at home to USC was followed by a 26-point defeat to Notre Dame, with Purdue surrendering a combined 89 points in those two games.
The benefit of a bye week probably won’t be enough for Purdue to prepare for Illinois. The Illini are averaging 35.8 ppg, and outside of the surprising blowout defeat to the Indiana Hoosiers, no team has held them below 34 points.
Purdue is allowing an average of 6.1 yards per play, and it hasn’t been particularly effective against either the run or the pass. Those struggles have been especially pointed against the aerial attack, with the Boilermakers allowing opposing teams to complete 65.3% of their passes.
Illinois quarterback Luke Altmyer has been effective all season, throwing 11 touchdowns without an interception, and he is coming off a 328-yard performance against USC. Altmyer should lead the Illini to enough points to blow out a Purdue offense that’s been largely one-dimensional and lacking a ground game.
Illinois vs Purdue same-game parlay
I like the Illinois offense to roll in this matchup, doing enough to carry the Over with a little help from the Boilermakers.
Justin Bowick has scored in three of the first four games for the Illini this season, and his bet to pick up a touchdown on Saturday adds a lot of value to our SGP.
Illinois vs Purdue 3-leg SGP
- Illinois -9.5
- Over 55.5
- Justin Bowick anytime touchdown
Our deep-ball SGP: All Illini
Luke Altmyer will have a field day against a defense allowing 8.7 yards per passing attempt on the season.
Purdue has struggled to move the ball in the running game, and Mockobee finished Under 57.5 yards in each of his last two games.
Illinois vs Purdue 5-leg SGP
- Illinois -9.5
- Over 55.5
- Justin Bowick anytime touchdown
- Luke Altmyer Over 255.5 passing yards
- Devin Mockobee Under 57.5 rushing yards
Illinois vs Purdue odds
- Spread: Illinois -9.5 (-110) | Purdue +9.5 (-110)
- Moneyline: Illinois -375 | Purdue +300
- Over/Under: Over 55.5 (-110) | Under 55.5 (-110)
Illinois vs Purdue trend to know
Illinois is 8-1 ATS in its last nine games overall. Find more college football betting trends for Illinois vs Purdue.
How to watch Illinois vs Purdue
| Location | Ross-Ade Stadium, West Lafayette, IN |
| Date | Saturday, October 4, 2025 |
| Kickoff | 12:00 p.m. ET |
| TV | BTN |
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Odds are correct at the time of publishing and are subject to change.
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