The unbeaten Houston Cougars head to Corvallis for a Friday night non-conference clash against the winless Oregon State Beavers.
Houston has been one of the nation’s top teams against the spread, but my Houston vs. Oregon State predictions see the Beavers keeping this one competitive.
Read on for my college football picks for Friday, September 26.
Houston vs Oregon State prediction
Houston vs Oregon State best bet: Oregon State +13.5 (-110)
The Houston Cougars may be 13.5-point road favorites, but that number feels inflated. The Oregon State Beavers have faced two straight ranked opponents, while Houston’s schedule has been far softer.
The Beavers are 0-4 ATS, yet their average non-cover margin is under nine points, showing they’ve been competitive. Offensively, Oregon State is far more explosive than a year ago, already logging 15 passing completions of 20+ yards.
Oregon State quarterback Maalik Murphy and wideout Trent Walker will provide enough of a consistent vertical threat against a Cougars group boasting gaudy defensive numbers against inferior competition.
Defensively, the Beavers have major flaws, but Houston pivot Conner Weigman hasn’t shown he can consistently exploit secondaries downfield. He'll rack up the passing yards, but I don’t believe Houston can really hurt Oregon State enough to cover such a considerable number.
With Oregon State’s ability to generate big plays at home, I’m betting they're better than its 0-4 ATS mark. The Beavers will keep this game within the number.
Houston vs Oregon State same-game parlay
In addition to my best bet, Oregon State’s offense is explosive enough to put points on the board, while its struggling defense ensures points for both sides, pushing this game Over the total.
Weigman should exploit this weak Beavers secondary, making the Over 202.5 passing yards a solid addition to this parlay.
Houston vs Oregon State SGP
- Oregon +13.5
- Over 47.5
- Connor Weignman Over 202.5 passing yards
Our deep-ball SGP: Touchdown frenzy
- Dean Connors has scored a dozen touchdowns since 2024
- Trent Walker has already topped 300 receiving yards this season, and I like his chances of hauling in his first scoring strike of the year.
Houston vs Oregon State SGP
- Oregon +13.5
- Over 47.5
- Connor Weignman Over 202.5 passing yards
- Dean Connors anytime touchdown
- Trent Walker anytime touchdown
Houston vs Oregon State odds
- Spread: Houston -11.5 | Oregon State +11.5
- Moneyline: Houston -250 | Oregon State +200
- Over/Under: Over 48.5 | Under 48.5
Houston vs Oregon State trend to know
Houston is 2-1 to the Over in its last three games. Find more college football betting trends for Houston vs Oregon State.
How to watch Houston vs Oregon State
| Location | Reser Stadium, Corvallis, OR |
| Date | Friday, September 26, 2025 |
| Kickoff | 10:30 p.m. ET |
| TV | ESPN |
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Odds are correct at the time of publishing and are subject to change.
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