No. 8 Florida visits No. 25 Missouri after beating No. 4 Ole Miss 52-28, and my Florida vs. Missouri predictions still lean toward the Gators being in a tricky road spot.
The top pick is Under 57.5, while Missouri’s first-half moneyline offers a way to account for the emotional win without fading Florida across 60 minutes. Head over to our latest college football picks for more Week 5 betting analysis.
Who will win Florida vs Missouri: Florida -5.5
The Florida Gators just beat top-five Ole Miss 52-28, so a letdown argument is obvious with a road trip to face the Missouri Tigers ahead.
But I'm not letting that erase the matchup. I'll play the Gators to -6.
Florida ranks 14th in net adjusted EPA per play, while Missouri sits 72nd overall and 107th offensively. The Tigers’ defense is the reason this is not a runaway. It ranks 31st overall and third in pass success rate allowed. Florida can attack the softer part of the matchup on the ground, where its rushing offense ranks fifth in EPA per rush against Missouri’s 50th-ranked rush defense.
There's not a ton here to get you believing in head coach Eli Drinkwitz either. Since 2024, Missouri is 1-9 versus ranked teams, with its only win coming against No. 24 Boston College in 2024.
COVERS INTEL: Florida boasts the top offense in the country in adjusted EPA per play at +0.32.
TOP PICK
Florida vs Missouri Over/Under pick: Under 57.5
I'm playing the Under down to 57%.
If there's any hangover from Florida, this is one of the best ways to capitalize on it. A few late stat-padding touchdowns from the Gators made this number overinflated.
The Tigers rank sixth nationally in defensive success rate and third in pass success rate allowed. Florida will score, and I expect the Gators to cover, but they may need to earn points with longer drives instead of relying on constant explosiveness.
On the other side, I anticipate the Gators' defense to make Missouri uncomfortable. That unit has allowed just 0.07 EPA per play on early downs. That should help keep Missouri behind schedule, especially given that its offensive success rate sits ranks in the triple digits nationally.
Florida vs Missouri combo
Missouri’s defensive efficiency should keep this from becoming an early track meet, but Florida comes with the stronger profile in the downs that decide close games.
The Gators convert 61.9% of third- and fourth-down opportunities, sitting sixth nationally, while Missouri’s offense converts 42.9%, ranking 74th. That gives Florida a better chance to sustain the possessions that matter most after halftime, even if Missouri’s field position and home environment produce an early lead.
A competitive first half followed by Florida’s superior talent and coaching taking over is the vision for this combo.
Florida vs Missouri combo
- Florida -5.5
- Missouri first-half moneyline
- Under 57.5
- Top picks: 4-2, +1.73 units
- Combos: 1-5, -0.10 units
Florida vs Missouri odds
For help understanding probabilities, see our odds calculator.
- Spread: Florida -4.5 | Missouri +4.5
- Over/Under: Over 57.5 (48%) | Under 57.5 (52%)
- Moneyline: Florida 70% | Missouri 30%
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Florida vs Missouri weather
The forecast calls for mostly sunny skies in Columbia with a high around 72 degrees. There is no significant weather concern expected to affect the game.
Check out our college football weather page for up-to-date info on every matchup.
Florida vs Missouri trend to know
The Under is 6-0 in the Tigers' last six games in October. Find more college football betting trends for Florida vs. Missouri.
How to watch Florida vs Missouri
| Location | Memorial Stadium, Columbia, MO |
| Date | Saturday, Oct. 3, 2026 |
| Kickoff | 12:30 p.m. ET |
| TV | ABC |
Florida vs Missouri latest injuries
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