The Baltimore Orioles will try to put a disappointing 2025 behind them as they host the Minnesota Twins on Opening Day.
Baltimore has a rejuvenated lineup and a budding ace on the mound today, so I’m taking it to win outright in my Twins vs. Orioles predictions.
Read on to take a closer look at today’s matchup in my free MLB picks for Thursday, March 26.
Twins vs Orioles predictions
Twins vs Orioles best bet: Orioles moneyline (-138)
While both teams underperformed badly last season, their prospects are very different coming into 2026.
The Minnesota Twins face an uphill climb in the AL Central, but the Baltimore Orioles are a trendy dark horse World Series pick.
Those hopes hinge on a bounce-back season for Gunnar Henderson, and the addition of slugger Pete Alonso to the middle of the lineup.
Trevor Rogers is looking to repeat his outstanding 2025 for Baltimore, when he went 9-3 with a 1.81 ERA. I’m picking Rogers lead the Orioles to an Opening Day win over Joe Ryan and the Twins this afternoon.
COVERS INTEL: Joe Ryan went 3-5 with a 4.89 ERA and 1.309 WHIP over his last 10 starts to end the 2025 season.
Twins vs Orioles same-game parlay (SGP)
While I expect Baltimore’s offense to rebound a bit in 2026, it’s worth noting that they were a Bottom 10 offense in run-scoring last season, plating 4.18 runs per game – just behind Minnesota (4.19).
With both teams throwing their aces on Opening Day, I like the Under here.
One player I do see generating a bit of offense is Henderson, who hit .400 with a 1.267 OPS for the United States in the World Baseball Classic.
Even in a down year, Henderson scored 85 runs last season, and I like him to come across today.
Twins vs Orioles SGP
- Orioles moneyline
- Under 8.5
- Gunnar Henderson to score a run
Twins vs Orioles home run pick: Pete Alonso (+290)
Alonso was one of the biggest free agent moves in the offseason, and he’ll undoubtedly add a lot of punch to the middle of the Baltimore lineup.
The former Mets star has hit at least 34 home runs in every full season of his career, and his .871 OPS last season was his highest since his rookie season.
Ryan gave up seven homers in his last four starts of 2025, and I like Alonso to get off to a fast start in his new home.
Twins vs Orioles odds
- Moneyline: Minnesota +118 | Baltimore -138
- Run line: Minnesota +1.5 | Baltimore -1.5
- Over/Under: Over 8.5 | Under 8.5
Twins vs Orioles trend
The Twins were 1-6 in Ryan’s last seven starts in 2025. Find more MLB betting trends for Twins vs. Orioles.
How to watch Twins vs Orioles and game info
| Location | Oriole Park at Camden Yards, Baltimore, MD |
| Date | Thursday, March 26, 2026 |
| First pitch | 3:05 p.m. ET |
| TV | Twins TV, MASN |
| Twins starting pitcher | Joe Ryan (2025: 13-10, 3.42 ERA) |
| Orioles starting pitcher | Trevor Rogers (2025: 9-3, 1.81 ERA) |
Twins vs Orioles latest injuries
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Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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