The Chicago Cubs and San Diego Padres are both red hot and begin a tape-measuring, three-game set at Petco Park tonight.
My top Cubs vs. Padres predictions and MLB picks call for Chicago to earn the win in a low-scoring bout tonight.
Who will win Cubs vs Padres today: Cubs moneyline (-103)
The Chicago Cubs send a superior lineup to the dish with a seventh-ranked wOBA against righties, while this San Diego Padres offense ranks 28th in wOBA against lefties.
I’m confident in Cubbies southpaw Matthew Boyd, too. He’s a start removed from returning from his biceps injury and sports a rock-solid 3.39 ERA, 1.09 WHIP, and 3.74 xERA since joining the club in 2025.
Friars righty Randy Vasquez's 1.88 ERA is also miles below his 4.31 xERA, so I’m expecting hiccups navigating a Chicago lineup that’s specialized in timely hitting during an active 13-5 heater.
COVERS INTEL: The Cubs pace the majors in wOBA while averaging 6.0 runs per game during the highlighted 13-5 stretch.
Cubs vs Padres Over/Under pick: Under 8.5 (-133)
The No. 1 reason I like this Under is that while Vasquez is off to an unsustainable start, his fastball velocity and movement are up to generate more swinging strikes. It has enabled him to allow just four runs across 22 2/3 innings during his first two trips through the order over his five starts.
Add the wind blowing in at Petco Park to the highlighted San Diego struggles against lefties, and I expect Boyd to keep the Padres off balance at the dish, too.
Of course, San Diego has only played to the Over in 19 of its past 50 games, too.
- ML/RL bets: 12-7, +6.14 units
- Over/Under bets: 5-5, -0.64 units
Cubs vs Padres odds
- Moneyline: Cubs -102 | Padres -118
- Run line: Cubs -1.5 (+150) | Padres +1.5 (-182)
- Over/Under: Over 8 (-105) | Under 8 (-115)
Cubs vs Padres trend
The Cubs have won 10 of their last 12 games for +8.75 units and a 61% ROI. Find more MLB betting trends for Cubs vs. Padres.
How to watch Cubs vs Padres and game info
| Location | Petco Park, San Diego, CA |
| Date | Monday, April 27, 2026 |
| First pitch | 9:40 p.m. ET |
| TV | Marquee, Padres.TV |
| Cubs starting pitcher | Matthew Boyd (1-1, 5.79 ERA) |
| Padres starting pitcher | Randy Vasquez (2-0, 1.88 ERA) |
Cubs vs Padres latest injuries
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Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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