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Best NFL Picks Today

Find the best NFL bets today - Sept. 22, 2026. Free expert and computer picks for every NFL game.

New Computer Picks powered by Odds Shark

Predicted Score

ATL logo
ATL
ATL

19.47 @ 26.00

GB
GB logo
GB

Falcons vs Packers · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

ATL logo
ATL
ATL

19.47

+6.5 -108

o43.5 -124

+235

GB logo
GB
GB

26.00

-6.5 +100

u44.5 -109

-275

Kansas City @ Miami
Matchup Stats

Predicted Score

KC logo
KC
KC

26.23 @ 17.35

MIA
MIA logo
MIA

Chiefs vs Dolphins · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

KC logo
KC
KC

26.23

-10.5 -112

o45.5 -111

-700

MIA logo
MIA
MIA

17.35

+10.5 -108

u46.5 -115

+575

Carolina @ Cleveland
Matchup Stats

Predicted Score

CAR logo
CAR
CAR

18.22 @ 19.91

CLE
CLE logo
CLE

Panthers vs Browns · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

CAR logo
CAR
CAR

18.22

-2.5 -115

o41.5 -115

-145

CLE logo
CLE
CLE

19.91

+2.5 +105

u42.5 -110

+131

Tennessee @ N.Y. Giants
Matchup Stats

Predicted Score

TEN logo
TEN
TEN

18.04 @ 24.30

NYG
NYG logo
NYG

Titans vs Giants · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

TEN logo
TEN
TEN

18.04

+3.5 -110

o40.5 +100

+165

NYG logo
NYG
NYG

24.30

-3.5 -105

u40.5 -112

-170

New England @ Jacksonville
Matchup Stats

Predicted Score

NE logo
NE
NE

22.11 @ 23.80

JAC
JAC logo
JAC

Patriots vs Jaguars · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

NE logo
NE
NE

22.11

+3.5 -125

o45.0 -110

+140

JAC logo
JAC
JAC

23.80

-3.5 +110

u45.5 -108

-155

L.A. Chargers @ Buffalo
Matchup Stats

Predicted Score

LAC logo
LAC
LAC

20.78 @ 27.11

BUF
BUF logo
BUF

Chargers vs Bills · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

LAC logo
LAC
LAC

20.78

+7.5 -120

o50.0 -110

+310

BUF logo
BUF
BUF

27.11

-7.5 +100

u50.5 -114

-334

N.Y. Jets @ Detroit
Matchup Stats

Predicted Score

NYJ logo
NYJ
NYJ

19.49 @ 29.59

DET
DET logo
DET

Jets vs Lions · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

NYJ logo
NYJ
NYJ

19.49

+6.5 -102

o48.0 -109

+270

DET logo
DET
DET

29.59

-6.5 -110

u48.5 -115

-300

Houston @ Indianapolis
Matchup Stats

Predicted Score

HOU logo
HOU
HOU

23.83 @ 24.25

IND
IND logo
IND

Texans vs Colts · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

HOU logo
HOU
HOU

23.83

+0.0 -154

o43.5 +100

-142

IND logo
IND
IND

24.25

+2.5 +100

u43.5 -106

+130

Seattle @ Washington
Matchup Stats

Predicted Score

SEA logo
SEA
SEA

20.58 @ 19.42

WAS
WAS logo
WAS

Seahawks vs Commanders · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

SEA logo
SEA
SEA

20.58

+0.0 -333

o40.0 -110

-295

WAS logo
WAS
WAS

19.42

+0.0 +235

u40.5 -105

+270

Cincinnati @ Pittsburgh
Matchup Stats

Predicted Score

CIN logo
CIN
CIN

25.33 @ 21.63

PIT
PIT logo
PIT

Bengals vs Steelers · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

CIN logo
CIN
CIN

25.33

-3.5 -105

o42.0 -110

-182

PIT logo
PIT
PIT

21.63

+0.0 +148

u42.5 -107

+165

Arizona @ San Francisco
Matchup Stats

Predicted Score

ARI logo
ARI
ARI

20.91 @ 27.21

SF
SF logo
SF

Cardinals vs 49ers · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

ARI logo
ARI
ARI

20.91

+8.5 -110

o47.5 -115

+360

SF logo
SF
SF

27.21

-8.5 -105

u48.5 -115

-400

Minnesota @ Tampa Bay
Matchup Stats

Predicted Score

MIN logo
MIN
MIN

17.39 @ 22.30

TB
TB logo
TB

Vikings vs Buccaneers · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

MIN logo
MIN
MIN

17.39

-1.5 -105

o42.5 -115

-120

TB logo
TB
TB

22.30

+1.5 -106

u43.5 -112

+105

Baltimore @ Dallas
Matchup Stats

Predicted Score

BAL logo
BAL
BAL

26.55 @ 26.45

DAL
DAL logo
DAL

Ravens vs Cowboys · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

BAL logo
BAL
BAL

26.55

+0.0 -164

o52.5 -106

-148

DAL logo
DAL
DAL

26.45

+2.5 +105

u52.5 -105

+135

Las Vegas @ New Orleans
Matchup Stats

Predicted Score

LV logo
LV
LV

20.87 @ 26.78

NO
NO logo
NO

Raiders vs Saints · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

LV logo
LV
LV

20.87

+3.5 -118

o43.5 -105

+150

NO logo
NO
NO

26.78

-3.5 +100

u43.5 -105

-168

L.A. Rams @ Denver
Matchup Stats

Predicted Score

LA logo
LA
LA

23.15 @ 24.14

DEN
DEN logo
DEN

Rams vs Broncos · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

LA logo
LA
LA

23.15

-2.5 -105

o45.5 -110

-134

DEN logo
DEN
DEN

24.14

+2.5 -106

u45.5 -105

+118

Philadelphia @ Chicago
Matchup Stats

Predicted Score

PHI logo
PHI
PHI

22.60 @ 21.96

CHI
CHI logo
CHI

Eagles vs Bears · Prediction & Game Odds

Team

Predicted Score

Spread

Total

ML

PHI logo
PHI
PHI

22.60

+0.0 -172

o43.5 -111

-167

CHI logo
CHI
CHI

21.96

+3.0 -105

u44.5 -110

+155

Carolina Panthers image thumbnail CAR @ Cleveland Browns image thumbnail CLE Sun, Sep 27 • 1:00 PM ET
Total
Carolina Panthers image thumbnail Cleveland Browns image thumbnail o41.0 (-110)
Best Odds
Pick made: 18 hours ago
Jason Logan logo
Jason Logan
Senior Betting Analyst

The Cleveland Browns finished No. 6 in EPA per dropback in Week 2. Deshaun Watson had his best game in a long time despite the Bucs bringing the heat, picking up 7.0 yards per pass. Carolina has thrown on 64% of dropbacks after a shootout with Chicago and a squash of Atlanta to kick off 2026. Quarterback Bryce Young is thriving with offensive coordinator Brad Idzik calling plays. He’s Top 10 in all the fancy passing stats, including air yards. Both teams have given up plays over the top, sitting sixth and seventh in most air yards allowed. The Panthers defense looks tougher than it truly is after fattening up on the Falcons’ backup QBs in Week 2. Carolina still got gashed for 157 rushing yards from Atlanta, despite focusing their energy on stuffing the run.

Total
Carolina Panthers image thumbnail Cleveland Browns image thumbnail o41.5 (-103)
Best Odds
Pick made: 18 hours ago
Shawn Krest logo
Shawn Krest
Betting Analyst

Brad Izdik's new offense in Carolina is the real deal--aggressive and explosive. The Browns are more conservative, but the young players at receiver and on the line are delivering. 

View 3 Picks
Tennessee Titans image thumbnail TEN @ New York Giants image thumbnail NYG Sun, Sep 27 • 1:00 PM ET
Spread
New York Giants image thumbnail NYG -5.5 (-115)
Best Odds
Pick made: yesterday
Neil Parker logo
Neil Parker
Betting Analyst

Grabbing this -5.5 line before Monday Night Football because I’m expecting the Giants to hang with the Los Angeles Rams in Week 2, and New York will be an even larger home favorite over Tennessee by Sunday afternoon. The Titans were only on offense for 23:35 against the Philadelphia Eagles on Sunday, and QB Cam Ward has thrown for just 6.2 yards per attempt through two weeks. Tennessee also hits the highway for the first time in 2026, and the new-look G-Men put on an offensive clinic in their season opener at MetLife Stadium. 

View Pick
New England Patriots image thumbnail NE @ Jacksonville Jaguars image thumbnail JAC Sun, Sep 27 • 1:00 PM ET
Spread
Jacksonville Jaguars image thumbnail JAC -2.5 (-110)
Best Odds
Pick made: yesterday
Jason Logan logo
Jason Logan
Senior Betting Analyst

I won’t discount the Jaguars too much for having a tough day in Denver. Jacksonville gets to come home for what will be its only outing in Duval County until Week 8. The Patriots looked much better than they were against the corpse of Aaron Rodgers in Week 2. New England managed just 20 points – seven coming from a defensive score – went 4-for-12 on third down and 0 for 1 in the red zone. This Jaguars defense still did a lot right against the Broncos, standing tall on third downs and inside the red zone. I’ll take the home side short of the key number of three.

View Pick
New York Jets image thumbnail NYJ @ Detroit Lions image thumbnail DET Sun, Sep 27 • 1:00 PM ET
Total
New York Jets image thumbnail Detroit Lions image thumbnail u48.5 (-120)
Best Odds
Pick made: 11 hours ago
Ed Scimia logo
Ed Scimia
Betting Analyst

The New York Jets have allowed just 4.0 yards per play, third-best in the NFL, and rank sixth in EPA per defensive play for the season. And while the Detroit Lions have given up an embarrassing 457.5 yards per game on defense, Geno Smith and the New York offense haven't shown any signs that they can even approach that kind of number. I'm backing the Under at totals as low as 47.5 points.

Spread
Detroit Lions image thumbnail DET -6.5 (-116)
Best Odds
Pick made: 11 hours ago
Ed Scimia logo
Ed Scimia
Betting Analyst

The New York Jets defense still looks legit, but the offense sputtered against its first real taste of adversity, totaling just 285 yards against the Green Bay Packers. That won't be enough to deal with a Detroit Lions team that has averaged 362 yards and 31.0 ppg on offense this season. I'm backing the Lions to cover at -6.5 points.

View 2 Picks
Houston Texans image thumbnail HOU @ Indianapolis Colts image thumbnail IND Sun, Sep 27 • 1:00 PM ET
Total
Houston Texans image thumbnail Indianapolis Colts image thumbnail o43.5 (-116)
Best Odds
Pick made: 16 hours ago
Dustin Saracini logo
Dustin Saracini
Senior Analyst

We have two teams that have hit the Over in three of four games this year, leading me to believe that this number is far too low. The Colts' defense is simply the worst in football so far, giving up a total of eight touchdowns through two weeks. Most of these are due to a struggling red-zone unit, which is coughing up a score 67% of the time. So what's been working for Indy? Undeniably, its offense, which is scoring at an 84% clip once they get inside the 20. While yes, the Colts are going up against one of the better defensive units in football, Houston has still allowed over 350 yards of total offense in the early parts of 2026. What does this all add up to? An Over. Play this up to 55%.

Spread
Houston Texans image thumbnail HOU -2.5 (-137)
Best Odds
Pick made: 16 hours ago
Dustin Saracini logo
Dustin Saracini
Senior Analyst

The Houston Texans defense has faced two of the most potent offenses in football, the Buffalo Bills and Cincinnati Bengals, and still comes out on top in virtually every statistical category against the Indianapolis Colts. The Colts have a major issue, allowing 514 total yards per game - the most in the NFL by almost 60 yards. That coincides with allowing 37 points per game, also the worst mark in the league. They'll be going up against an offense that ranks in the top 10 in yards per game, which is good enough for me to get behind the Texans, even if Nico Collins misses another game. I'm expecting David Montgomery to run all over Indy, which is allowing 5.4 yards per carry through two weeks of the season. Comfortably fade the Colts and play this up to 60%.

View 2 Picks
Cincinnati Bengals image thumbnail CIN @ Pittsburgh Steelers image thumbnail PIT Sun, Sep 27 • 1:00 PM ET
Moneyline
Cincinnati Bengals image thumbnail CIN (-174)
Best Odds
Pick made: yesterday
Jason Logan logo
Jason Logan
Senior Betting Analyst

Pittsburgh takes a series step up in competition and this is no longer the Steelers we could count on under Mike Tomlin. Aaron Rodgers is done and Cincinnati is looking like the best two-way team in the NFL, after handling Houston on the road in Week 3. The Bengals have collected eight sacks in the first two games and I wouldn’t be surprised if Rodgers doesn’t make it through Week 3, given the pounding he took in New England.  Oh, and Joe Burrow is absolutely firing on all cylinders. He’s surgical versus zone coverage and will slice up Patrick Graham’s passive playcalling. I'm taking Cincy ML before this price ticks up to two bucks or higher.

View Pick
Minnesota Vikings image thumbnail MIN @ Tampa Bay Buccaneers image thumbnail TB Sun, Sep 27 • 4:05 PM ET
Total
Minnesota Vikings image thumbnail Tampa Bay Buccaneers image thumbnail u42.5 (-108)
Best Odds
Pick made: 14 hours ago
Dustin Saracini logo
Dustin Saracini
Senior Analyst

We're seeing two mediocre offenses against two top-10 defenses in Week 3. The Vikings have had to play mistake-free football on both sides of the ball - their defense has allowed an average of just 12.5 points per game as a result. It's also one of the best red-zone defenses this year, allowing a touchdown on just 12% of trips inside the 20. With positive regression looming for the Bucs' defense against Murray and Co. I'm projecting this total to close closer to 40.5.

Spread
Tampa Bay Buccaneers image thumbnail TB +1.5 (-111)
Best Odds
Pick made: 14 hours ago
Dustin Saracini logo
Dustin Saracini
Senior Analyst

The Tampa Bay Buccaneers are better than their 0-2 record indicates, and it's put-up-or-shut-up time against the Minnesota Vikings in Week 3 if they want to win a weak NFC South. It's probably a welcome sight that Kyler Murray will likely get the start, with Carson Wentz leading the Vikings to two wins in his absence. Murray played just 11 snaps in the team's opener before leaving with a concussion, and now draws a difficult matchup against a top-10 defense. Baker Mayfield hasn't gotten going this year yet (albeit, he was playing in rain in Week 2), but the offense has too much talent surrounding him to lay low for one more week. I'm expecting a bigger breakout in what should finally be a sunny day in Tampa.

View 2 Picks
Baltimore Ravens image thumbnail BAL @ Dallas Cowboys image thumbnail DAL Sun, Sep 27 • 4:25 PM ET
Total
Baltimore Ravens image thumbnail Dallas Cowboys image thumbnail o52.5 (-105)
Best Odds
Pick made: yesterday
Neil Parker logo
Neil Parker
Betting Analyst

Baltimore just allowed New Orleans Saints QB Tyler Shough to throw for 7.4 yards per attempt with a 79.4 completion percentage in Week 2, and now the Ravens go up against a Dallas offense that’s fourth in both EPA per play and offensive success rate ahead of Monday Night Football in Week 2. Of course, there’s no stop on defense for the Cowboys, and the Ravens respectively check in sixth and third in the two highlighted metrics. Finally, I anticipate the trip south to Maracana Stadium to also take its toll on the two defenses in Week 3.

View Pick

For every matchup in an NFL season, our NFL computer produces selections for a variety of different betting angles. Our computer picks are based on a proprietary algorithm that values each team in the current week to produce moneyline, spread, and point total selections.

The table above, below the game picks, tracks our NFL computer's results over the last 100 games, outlining the record and profit for selections, based on $100 unit size. We track the profit based on both opening and closing lines for every matchup.

How to Use NFL Computer Picks

The easiest way to utilize our computer picks is to simply follow our selections for every matchup, what you'd call ailing the computer." But there are other ways to utilize our NFL computer picks, as well.

You can use our NFL computer as a jumping-off point to do more research into specific lines, cross-referencing with expert picks, which can be found above the selections for some matchups, recent NFL betting trends, and more.

As well, you can gauge the confidence of the matchup. The larger the projected score, the more confident the computer is in a specific pick.

Or, if you want to implement a system, betting only on underdogs, for example, you can look for matchups in which our computer likes the underdog to inform which picks you're going to hone in on for a given week.

We have these computer picks for every sport you're looking to wager on, as well:

Free Computer Picks by Odds Shark

Moneyline

NFL moneyline picks are the simplest way to get in on the NFL action. All you have to do is simply bet on which team you think will win the game.

For moneyline picks, the favorite is represented with a minus sign (-) in front of the odds, while the underdog has a plus (+). However, you don't get the same profit for picking an underdog compared to a favorite. If the favored team is -120, a $100 bet on them would pay out $80 in profit and $180 total, if they win the game. The underdog winning at +150 would pay out a $150 profit, $250 total.

We have a complete breakdown of how to read NFL moneyline odds for these NFL computer picks.

Spread

While moneyline picks are the simplest, picking NFL games against the spread is probably the most common wager for regular NFL bettors.

To bet an NFL spread, you wager on whether a team will win by a certain number of points or more or if they'll lose by fewer points than the spread. For example, if the spread is -6.5 for the New England Patriots, you would win the bet if they win the game by 7 points or more. Or if a team is +6.5, you're betting on if they'll win outright or lose by fewer than 6.5 points.

There is a correlation between moneyline odds and the spread, as books set these lines based on the same information.

You can read more about NFL spreads here.

Totals (Over/Under)

If you aren’t entirely sold on which NFL team will win or cover in an NFL game, you can still use our NFL computer picks to bet on the point total.

As opposed to taking a side, in total or Over/Under betting, you wager on whether both NFL teams will combine for a final score of more than (Over) or less than (Under) the total number of points set by oddsmakers.

The computer picks, and your handicapping of totals is more about how you think both teams will score points, not which team has the edge to win.

More NFL Picks & Betting Tools

Our NFL Computer Picks are a great way to place weekly football wagers, but you should also consider handicapping games yourself using some of our other tools. If you're looking to bet on long-term futures this football season, check out some of our other dedicated pages:

Best Football Betting Sites

If you’re ready to bet on NFL picks, you first need to find the right sportsbook. Our NFL betting sites guide offers secure banking, the best odds, bonuses, and reliable customer service options for you.

NFL Free Picks FAQs

When do we release our NFL picks?

Covers NFL picks are released two to three days before each game on the NFL schedule.

What kinds of NFL picks do we make?

Covers provides free NFL picks covering many markets, including point spreads, totals, moneylines, player props, and more.