NFL Week 6 Picks: ChatGPT Predicts the Winner of Every Game

Week 6 of the NFL season promises to deliver fireworks, shifting power dynamics, and edge-of-your-seat drama. Parity has stormed in, and with no unbeaten teams remaining, the ride to the postseason is suddenly wide open.

Instead of leaving the picks to the talking heads, we've turned to artificial intelligence. Using the Week 6 moneyline odds from FanDuel, we asked ChatGPT to pick the straight-up winners of every single game on the schedule from the opening whistle on Thursday night to the final play on Monday.

Here’s how the AI sees Week 6 shaking out with its NFL picks. 

Week 6 NFL moneyline picks

Matchup	Pick
Eagles vs  Giants	-390
Broncos vs  Jets	-400
Cardinals vs  Colts	-330
Rams vs  Ravens	-370
Browns vs  Steelers	-275
Seahawks vs  Jaguars	-118
Chargers vs  Dolphins	+162
Cowboys vs  Panthers	-174
Patriots vs  Saints	-194
Titans vs  Raiders	-225
49ers vs  Buccaneers	-154
Bengals vs  Packers	-1200
Lions vs  Chiefs	-138
Bills vs  Falcons	-225
Bears vs  Commanders	-215

Lines courtesy of FanDuel.

Eagles vs Giants: Eagles (-390)

The Eagles are significant road chalk for a reason: Their overall roster depth and trench play typically travel, and they face a rebuilding Giants team still searching for offensive consistency. On a short week, backing the better offensive line and the more stable defense is a straightforward angle. I’m siding with the favorite to handle the moment and keep the NFC East pace.

Broncos vs Jets: Broncos (-400)

Early kick, neutral site, and Denver brings the better recent form with a defense that’s tightened up in key spots. London can be quirky, but reduced home-field edges amplify talent gaps, and the Broncos are priced like clear favorites for good reason. I’ll lean with the market and take Denver to grind out a London win.

Cardinals vs Colts: Colts (-330)

Indianapolis has been a steady home performer, and this number reflects that edge. The Colts should control the script with balance and keep Arizona chasing. As sizable favorites, they don’t need style points — just a clean, low-mistake outing.

Rams vs Ravens: Rams (-370)

This is a hefty road price, but it reflects current trajectories. Los Angeles should control passing efficiency and leverage favorable down-and-distance, while Baltimore’s turnover issues make catching up difficult. I’ll follow the board and lay the ML with LA.

Browns vs Steelers: Steelers (-275)

Pittsburgh off extra rest at home is typically a tough nut to crack. Even if this turns into a field-position grind, the Steelers’ defensive havoc rate plays well against a young Cleveland offense. Laying the moneyline avoids a possible late backdoor.

Seahawks vs Jaguars: Jaguars (-118)

Near pick’em pricing usually swings on travel and situational rest. Jacksonville’s slight edge at home and potential for a better scripted start nudges this for me. With both teams able to score in bunches, I’m avoiding the spread and siding with the tiny home moneyline.

Chargers vs Dolphins: Dolphins (+162)

Traveling east for an early kick can sap an offense’s timing, and Miami’s playmakers at home usually tilt the field position battle. With a manageable price for the hosts and a modest total, a Dolphins moneyline pairs “safer” than a spread sweat.

Cowboys vs Panthers: Cowboys (-174)

Dallas’ offense has been adaptable despite injuries, and the Panthers’ recent uptick feels more opponent-driven than sustainable. In what projects as a higher-variance total, the “safer” route is the visitors straight up rather than trusting a road cover. 

Patriots vs Saints: Patriots (-194)

New England enters with confidence after a marquee win and now faces a Saints team still searching for weekly identity. On a neutral number near a field goal, I’ll back the steadier defensive baseline and a quarterback who’s protecting the ball.

Titans vs Raiders:  Raiders (-225)

Las Vegas returns home needing a rebound spot, and the Titans’ offense can sputter if forced into third-and-long. The number implies a clear but not overwhelming gap — perfect for a moneyline inclusion in parlays, but also fine as a solo play.

49ers vs Buccaneers: Buccaneers (-154)

Tampa’s defense has been timely, and the offense has done enough to win tight scripts. In a matchup where both fronts can win, I’ll defer to home field and the shorter travel. Moneyline keeps you safe from a one- or two-point squeaker.

Bengals vs Packers: Packers (-1200)

Green Bay’s massive number says it all. With Lambeau wind or not, the Packers’ defense should feast on a Bengals team still searching for rhythm. This is “survivor-pool chalk” territory — expensive, but justified.

Lions vs Chiefs: Chiefs (-138)

Arrowhead at night is rarely friendly to visitors. Detroit can absolutely punch back, but late-game red-zone execution and situational defense tilt toward Kansas City at home. At sub -150, this price is reasonable for a stand-alone play.

Bills vs Falcons:  Bills (-225)

Buffalo’s offense remains explosive enough to overcome a few negative plays, and the defense can force Atlanta into predictable pass downs. On a fast track indoors, the favorite’s ceiling wins out more often than not.

Bears vs Commanders: Commanders (-215)

Washington’s pass rush paired with a home crowd is a tough combo for a Bears attack still developing week-to-week answers. The number implies a solid but not dominant edge; ML protection feels appropriate in a potentially choppy primetime flow.

ChatGPT has gone 52-25 so far this season for +24.5 units.

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