The 2-3 Arizona Cardinals are coming off an embarrassing collapse at home and will be looking to bounce back when they travel to Lucas Oil Stadium to take on the 4-1 Indianapolis Colts.
The Colts have several advantages in this matchup, but there is one advantage the Cardinals have that leads to a solid player prop.
Find out who I like in my Cardinals vs. Colts predictions and NFL picks for Sunday, October 12.
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Cardinals vs Colts prediction
Cardinals vs Colts Best bet: Marvin Harrison Jr. longest reception Over 22.5 yards (-108 at FanDuel)
The Indianapolis Colts rank near the top of the NFL in almost every statistical category thus far this season. However, they do rank 30th in the league in defending deep passes – passes over 20 air yards downfield.
Marvin Harrison Jr. will be facing the team where his father is the all-time leader in receptions, receiving yards, and receiving touchdowns.
He is going to want to show out here in Indianapolis in honor of his father. He is also a big-time deep threat for the Arizona Cardinals to take advantage of that poor deep passing defense.
Harrison Jr. is averaging 15.3 yards per catch this season. He has also seen six targets of at least 20+ air yards this season. On those six targets, he has caught four for 136 yards, which is 34.0 yards per reception.
After a slow start to the season, MHJ has been heavily involved the last two weeks. With them likely playing from behind, there should be multiple opportunities for Harrison Jr. to connect with Kyler Murray on some deep routes.
Cardinals vs Colts same-game parlay
To add to my best bet, I am going to add the Over, as the Colts average 38.0 points per game when playing a defense in the bottom half of the NFL.
Finally, I am taking Tyler Warren to find the endzone. He has scored in each of the last two games.
- Marvin Harrison Jr. longest reception Over 22.5 yards
- Over 47.5
- Tyler Warren anytime touchdown
Our big-play SGP: Offense Aplenty
Michael Carter was the bell cow back last week and I expect more of the same with all their injuries and he will find the endzone.
- Marvin Harrison Jr. longest reception Over 22.5 yards
- Over 47.5
- Tyler Warren anytime touchdown
- Michael Carter anytime touchdown
Cardinals vs Colts odds
- Spread: Arizona +7 (-115) | Indianapolis -7 (-105)
- Moneyline: Arizona +250 | Indianapolis -310
- Over/Under: Over 47.5 (-105) | Under 47.5 (-115)
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Cardinals vs Colts betting trend to know
The Indianapolis Colts have hit the Game Total Over in 11 of their last 20 games. Find more NFL betting trends for Cardinals vs. Colts.
How to watch Cardinals vs Colts
| Location | Lucas Oil Stadium, Indianapolis, IN |
| Date | Sunday, October 12, 2025 |
| Kickoff | 1:00 p.m. ET |
| TV | FOX |
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