The NFL Week 2 odds feature a number of marquee matchups, kicking off with the Commanders vs. Packers on TNF, the Falcons vs. Vikings on SNF... and a massive Super Bowl rematch with Jalen Hurts and the Eagles visiting Patrick Mahomes and the Chiefs.
With Week 1 set to kick off, here are the look-ahead NFL odds for Week 2.
NFL odds Week 2
| Matchup | Spread | Moneyline | Over/Under |
|---|---|---|---|
 Commandersvs  Packers |
Packers -3.5 | Commanders +146 Packers -174 |
48.5 |
 Brownsvs  Ravens |
Ravens -12.5 | Browns +500 Ravens -700 |
46.5 |
 Billsvs  Jets |
Jets +7.5 | Bills -450 Jets +350 |
44.5 |
 Patriotsvs  Dolphins |
Dolphins -2.5 | Patriots +128 Dolphins -152 |
45.5 |
 49ersvs  Saints |
Saints +7.5 | 49ers -340 Saints +275 |
44.5 |
 Seahawksvs  Steelers |
Steelers -2.5 | Seahawks +114 Steelers -134 |
40.5 |
 Ramsvs  Titans |
Titans +5.5 | Rams -240 Titans +198 |
44.5 |
 Bearsvs  Lions |
Lions -5.5 | Bears +200 Lions -245 |
48.5 |
 Jaguarsvs  Bengals |
Bengals -4.5 | Jaguars +194 Bengals -235 |
50.5 |
 Giantsvs  Cowboys |
Cowboys -3 | Giants +122 Cowboys -144 |
44.5 |
 Panthersvs  Cardinals |
Cardinals -5.5 | Panthers +188 Cardinals -225 |
45.5 |
 Broncosvs  Colts |
Colts +3 | Broncos -164 Colts +138 |
44.5 |
 Eaglesvs  Chiefs |
Chiefs -1.5 | Eagles -104 Chiefs -112 |
45.5 |
 Falconsvs  Vikings |
Vikings -4.5 | Falcons +172 Vikings -205 |
44.5 |
 Buccaneersvs  Texans |
Texans -2.5 | Buccaneers +108 Texans -126 |
45.5 |
 Chargersvs  Raiders |
Raiders +3 | Chargers -152 Raiders +128 |
43.5 |
Lines as of 9-3
Commanders vs Packers odds (Thursday, 8:15 p.m. ET, Prime Video)
Opening line
- Packers -3.5
- Over/Under 48.5
- View full Commanders vs. Packers odds and matchup
- Read our Commanders vs. Packers picks and predictions (coming soon)
Opening line analysis coming soon!
Also see: full Thursday Night Football odds
Browns vs Ravens odds (Sunday, 1:00 p.m. ET, CBS)
Opening line
- Ravens -12.5
- Over/Under 46.5
- View full Browns vs. Ravens odds and matchup
- Read our Browns vs. Ravens picks and predictions (coming soon)
Opening line analysis coming soon!
Bills vs Jets odds (Sunday, 1:00 p.m. ET, CBS)
Opening line
- Jets +7.5
- Over/Under 44.5
- View full Bills vs. Jets odds and matchup
- Read our Bills vs. Jets picks and predictions (coming soon)
Opening line analysis coming soon!
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Patriots vs Dolphins odds (Sunday, 1:00 p.m. ET, CBS)
Opening line
- Dolphins -2.5
- Over/Under 45.5
- View full Patriots vs. Dolphins odds and matchup
- Read our Patriots vs. Dolphins picks and predictions (coming soon)
Opening line analysis coming soon!
49ers vs Saints odds (Sunday, 1:00 p.m. ET, FOX)
Opening line
- Saints +7.5
- Over/Under 44.5
- View full 49ers vs. Saints odds and matchup
- Read our 49ers vs. Saints picks and predictions (coming soon)
Opening line analysis coming soon!
Seahawks vs Steelers odds (Sunday, 1:00 p.m. ET, FOX)
Opening line
- Steelers -2.5
- Over/Under 40.5
- View full Seahawks vs. Steelers odds and matchup
- Read our Seahawks vs. Steelers picks and predictions (coming soon)
Opening line analysis coming soon!
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Rams vs Titans odds (Sunday, 1:00 p.m. ET, CBS)
Opening line
- Titans +5.5
- Over/Under 44.5
- View full Rams vs. Titans odds and matchup
- Read our Rams vs. Titans picks and predictions (coming soon)
Opening line analysis coming soon!
Bears vs Lions odds (Sunday, 1:00 p.m. ET, FOX)
Opening line
- Lions -5.5
- Over/Under 48.5
- View full Bears vs. Lions odds and matchup
- Read our Bears vs. Lions picks and predictions (coming soon)
Opening line analysis coming soon!
Jaguars vs Bengals odds (Sunday, 1:00 p.m. ET, CBS)
Opening line
- Bengals -4.5
- Over/Under 50.5
- View full Jaguars vs. Bengals odds and matchup
- Read our Jaguars vs. Bengals picks and predictions (coming soon)
Opening line analysis coming soon!
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Giants vs Cowboys odds (Sunday, 1:00 p.m. ET, FOX)
Opening line
- Cowboys -3
- Over/Under 44.5
- View full Giants vs. Cowboys odds and matchup
- Read our Giants vs. Cowboys picks and predictions (coming soon)
Opening line analysis coming soon!
Panthers vs Cardinals odds (Sunday, 4:05 p.m. ET, CBS)
Opening line
- Cardinals -5.5
- Over/Under 45.5
- View full Panthers vs. Cardinals odds and matchup
- Read our Panthers vs. Cardinals picks and predictions (coming soon)
Opening line analysis coming soon!
Broncos vs Colts odds (Sunday, 4:05 p.m. ET, CBS)
Opening line
- Colts +3
- Over/Under 44.5
- View full Broncos vs. Colts odds and matchup
- Read our Broncos vs. Colts picks and predictions (coming soon)
Opening line analysis coming soon!
Eagles vs Chiefs odds (Sunday, 4:25 p.m. ET, FOX)
Opening line
- Chiefs -1.5
- Over/Under 45.5
- View full Eagles vs. Chiefs odds and matchup
- Read our Eagles vs. Chiefs picks and predictions (coming soon)
Opening line analysis coming soon!
Falcons vs Vikings odds (Sunday, 8:20 p.m. ET, NBC)
Opening line
- Vikings -4.5
- Over/Under 44.5
- View full Falcons vs. Vikings odds and matchup
- Read our Falcons vs. Vikings picks and predictions (coming soon)
Opening line analysis coming soon!
Buccaneers vs Texans odds (Monday, 7:00 p.m. ET, ABC/ESPN)
Opening line
- Texans -2.5
- Over/Under 45.5
- View full Buccaneers vs. Texans odds and matchup
- Read our Buccaneers vs. Texans picks and predictions (coming soon)
Opening line analysis coming soon!
Also see: full Sunday Night Football odds
Chargers vs Raiders odds (Monday, 10:00 p.m. ET, ESPN)
Opening line
- Raiders +3
- Over/Under 43.5
- View full Chargers vs. Raiders odds and matchup
- Read our Chargers vs. Raiders picks and predictions (coming soon)
Opening line analysis coming soon!
Also see: full Monday Night Football odds
Best NFL bets this week
Looking for our favorite spread, total, and NFL prop bets for this week's action? Check out our best free NFL picks from the Covers staff!
Odds are correct at the time of publishing and are subject to change.
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