Week 2 of the 2025 NFL season is here, and the excitement is just beginning.
After a thrilling opening week, we're about to discover which teams are contenders and which teams are pretenders. Every snap, every drive, and every goal-line stand matters.
Instead of leaving the picks to the talking heads, we turned to artificial intelligence instead. Using the Week 2 moneyline odds from FanDuel, we asked ChatGPT to pick the straight-up winners of every single game on the schedule from the opening whistle on Thursday night to the final play on Monday.
Here’s how the AI sees Week 2 shaking out with its NFL picks.
Week 2 NFL moneyline picks
| Matchup | Pick |
|---|---|
 Commanders vs  Packers |
-184 |
 Rams vs  Titans |
-250 |
 Seahawks vs  Steelers |
+130 |
 Bills vs  Jets |
-320 |
 Bears vs  Lions |
-260 |
 Giants vs  Cowboys |
-240 |
 Browns vs  Ravens |
-750 |
 49ers vs  Saints |
-235 |
 Patriots vs  Dolphins |
+100 |
 Jaguars vs  Bengals |
-176 |
 Panthers vs  Cardinals |
-310 |
 Broncos vs  Colts |
+104 |
 Eagles vs  Chiefs |
-106 |
 Falcons vs  Vikings |
-186 |
 Buccaneers vs  Texans |
+126 |
 Chargers vs  Raiders |
-176 |
Lines courtesy of FanDuel. ChatGPT is 14-2 this season (87.5%).
Commanders vs Packers: Packers (-184)
Green Bay enters off a dominant Week 1, especially on defense, whereas Washington looked solid but faces a tougher challenge on the road. Jordan Love’s experience and home-field edge at Lambeau give the Packers an edge.
Rams vs Titans: Rams (-250)
Tennessee struggled to finish in Week 1, and their offense looks vulnerable. The Rams, though flawed, have shown flashes, especially with their receiving corps. Expect a closer game than many think, but L.A. has the better upside.
Seahawks vs Steelers: Steelers (+130)
Seattle’s offense isn’t pretty, but they play with urgency and opportunism. Pittsburgh’s defense has potential, but their offense has to be sharper. On the road underdog, Seattle may surprise.
Bills vs Jets: Bills (-320)
The Bills’ offense is dangerous and tends to lean on their home crowd. The Jets have some weapons but struggled under pressure in Week 1. Buffalo’s proven ability in tight spots and ability to generate explosive plays gives them the edge.
Bears vs Lions: Lions (+210)
Detroit’s offense was sluggish in Week 1 but the matchup here is favorable. Playing at home indoors helps, and Chicago looked vulnerable defensively. The Lions should control tempo and capitalize on favorable matchups.
Giants vs Cowboys: Cowboys (-240)
The Cowboys aim to bounce back at home after a disappointing loss in Week 1. The Giants are still searching for consistency, particularly on offense, and Russell Wilson remains under scrutiny. In this rivalry, at home, Dallas should have enough.
Browns vs Ravens: Ravens (-750)
Baltimore showed plenty of offense even in a narrow loss to the Bills, and their home crowd helps amplify every possession. Cleveland had heartbreak in Week 1, but questions persist about their ability to sustain pressure and avoid mistakes. The Ravens’ talent and momentum favor them.
49ers vs Saints: 49ers (-235)
The 49ers dealt with injuries early, but even limited, they often rely on defense and control of the clock. The Saints have some upside, but consistency remains an issue. San Francisco should just about do enough.
Patriots vs Dolphins: Patriots (+100)
Both teams lost in Week 1, but Miami looked particularly out of sorts. The Patriots showed some fight and have a more stable offensive plan. As an underdog, New England offers value here, especially if the line moves.
Jaguars vs Bengals: Bengals (-176)
After a shaky opener, Cincinnati should benefit from getting into rhythm. Their quarterback / receiver matchups are dangerous, especially if the Jaguars’ defense doesn’t improve quickly. Expect the Bengals to find some separation in the second half.
Panthers vs Cardinals: Cardinals (-310)
Arizona has a home-field boost and more offensive weapons in this spot. Carolina looked off in Week 1, especially in execution and turnovers. The Cardinals are more reliable in red-zone chances and should be favored in a tight game.
Broncos vs Colts: Colts (+104)
Indianapolis looked strong in Week 1, confident under new leadership. Denver had issues on offense, turning the ball over and failing to sustain drives. In a home game, give me the Colts.
Eagles vs Chiefs: Chiefs (-106)
Super Bowl rematch energy is real, and KC at Arrowhead provides some serious edge. Mahomes & Co. looked dangerous last week, even in a loss. The Eagles are good, but I lean towards the Chiefs at home.
Falcons vs Vikings: Vikings (-186)
The Vikings get a home crowd boost and avoid long travel. Atlanta is dealing with injuries, especially at receiver, and their offense might not have enough tools to keep up in a shootout.
Buccaneers vs Texans: Buccaneers (+126)
Houston struggled protecting C.J. Stroud in Week 1, and with key offensive line injuries, they may continue to have issues. Tampa Bay has shown flashes of life, especially in tight games, and should be able to steal this one.
Chargers vs Raiders: Chargers (-176)
The Chargers opened well with a 27-21 win over the Chiefs, especially in their passing game. The Raiders looked strong in Week 1 against the Pats, but consistency and secondary coverage have been questionable. L.A. has the more stable offensive identity to close this.
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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