Week 2 of preseason NFL football continues Saturday afternoon in Indianapolis, IN, with the Green Bay Packers taking on the Indianapolis Colts.
There is still a huge starting quarterback battle for the Colts, while the Packers will look to see what their backups and guys looking to make the roster can do.
Here is my top Packers vs. Colts prediction and NFL picks for Week 2 of the preseason on Saturday, August 16.
Packers vs Colts prediction
Packers vs Colts Best bet: Colts -3.5 — 1H (-105)
I fell for the Indianapolis Colts starters to cover the first half last week against backups and was burned, but I feel a little more comfortable rolling with them this time. We are going to start with Daniel Jones instead of Anthony Richardson, and hopefully no injuries this time around.
Jones had to come in earlier than expected last week, and that may have thrown off their game plan a bit. They also allowed a punt return for a touchdown and a kick return for nearly 70 yards that resulted in a touchdown on the following drive. You must think they worked on special teams after that disaster.
The Green Bay Packers will not only be resting their starting quarterback and running back but also almost all their top receivers. Five of the top six receivers on the depth chart missed the joint practice on Thursday and will almost surely sit out this game as well.
Last week, the Packers only scored three points in the first half despite starting Jordan Love and many of their top receivers for two drives. They only scored seven points the rest of the game with the backups, and that was in the fourth quarter.
The Colts' run defense is bad, and they must make sure they contain the Packers there, but if they do, then they should have absolutely no issue covering this first-half spread.
Packers vs Colts odds
- Spread: Packers +4.5 | Colts -4.5
- Moneyline: Packers +173 | Colts -218
- Over/Under: Over 39.5 | Under 39.5
How to watch Packers vs Colts
| Location: | Lucas Oil Stadium, Indianapolis, IN |
| Date: | Saturday, 8-16, 2025 |
| Kickoff: | 1:00 p.m. ET |
| TV: | WGBA-TV |
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