We're in for an exciting TNF affair when the Dallas Cowboys head to the Motor City to take on the Detroit Lions.
Points should come in bunches, and our Cowboys vs. Lions predictions have you covered with a plethora of NFL picks for December 4.
Cowboys vs Lions TNF predictions
- Lions -3 (-115 at bet365)
- Over 53.5 (-110 at bet365)
- Pickens anytime TD (+120 at bet365)
- Gibbs Over 35.5 receiving yards (-110 at bet365)
Cowboys vs Lions TNF best bets
Lions -3
Joe Osborne is backing the trends and taking Detroit to cover on Thursday Night Football.
"The Detroit Lions have consistently responded well after losses, going 13-1 ATS in their last 14 games following an outright loss while showing major offensive spikes in those bounce-back spots. Even though they’ve struggled against top-tier defenses, this matchup is far more favorable against a Dallas Cowboys' unit that ranks near the bottom in points allowed and other key defensive categories."
Over 53.5
With two high-octane offenses doing battle, Osborne is all in on the Over.
"These teams rank second and third in scoring, and both defenses have clear vulnerabilities that should lead to steady drives and plenty of explosive plays. Detroit can take advantage of Dallas’ struggles against the run and on third downs, while the Cowboys’ passing game is well-positioned to attack a Lions defense that’s been picked apart through the air."
Cowboys vs Lions TNF TD picks
George Pickens
Kyle LaRusic is backing George Pickens to find the end zone against this leaky Lions' secondary.
"George Pickens has been everything as advertised since coming to Dallas, and he's become one of Dak's favorite targets. The "WR2" is tied for the team lead with eight touchdowns and ranks first in both targets and catches. That holds when the Cowboys reach the red zone, with Pickens catching seven of his team-high 15 RZ targets."
Cowboys vs Lions TNF props
Jahmyr Gibbs Over 35.5 receiving yards
Rohit Ponnaiya is expecting a huge game from Detroit's RB1 Jahmyr Gibbs.
"The Cowboys lead the league in pressure rate, so expect Lions QB Jared Goff to rely on shorter throws and outlet options like Jahmyr Gibbs. With tight end Sam Laporta on the IR and No. 1 WR Amon-Ra St. Brown injuring his ankle last week, there will be plenty of targets to go around."
Cowboys vs Lions odds
Cowboys vs Lions game info
| Location: | Ford Field, Detroit, MI |
| Date: | Thursday, December 4, 2025 |
| Kickoff: | 8:15 p.m. ET |
| TV: | Amazon Prime |
Cowboys vs Lions latest injuries
Cowboys vs Lions weather
Monitor gametime conditions with our live NFL weather info and learn how weather impacts NFL betting.
Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
Affiliate Disclosure: Our team of experts has thoroughly researched and handpicked each product that appears on our website. We may receive compensation if you sign up through our links.
