Anytime Touchdown Scorer Panthers vs 49ers Prediction: TD Picks for Monday Night Football Week 12

Rico Dowdle was held out of the red zone last week, but he'll find paydirt again in Week 12.

Ryan Gilbert - Contributor at Covers.com
Ryan Gilbert • Betting Analyst
Nov 23, 2025 • 16:24 ET • 4 min read
Carolina Panthers running back Rico Dowdle (5) runs with the ball in the first quarter against the Atlanta Falcons at Mercedes-Benz Stadium.
Photo By - Imagn Images. Carolina Panthers running back Rico Dowdle (5) runs with the ball in the first quarter against the Atlanta Falcons at Mercedes-Benz Stadium.

The San Francisco 49ers are looking to win consecutive games for the first time since September when they host the Carolina Panthers on Monday Night Football.

The total is set at 49.5 for this Monday Night Football matchup, so there should be more than a few touchdowns. Here are my best free Panthers vs. 49ers anytime touchdown picks for Monday, November 24.

For more NFL picks, check out our complete Panthers vs. 49ers predictions

Panthers anytime touchdown pick

Rico Dowdle (-140 at bet365)

Rico Dowdle put up 100 total yards last week in Atlanta but saw his two-game touchdown streak come to an end in the overtime win. He scored a rushing touchdown the previous week against the Saints, and two before that at Green Bay.

Dowdle leads the Panthers with six TDs on the season after signing in Carolina in the offseason. There aren’t a ton of offensive weapons on the Carolina Panthers, so Dowdle has become their go-to back even after Chubba Hubbard returned from injury.

The 49ers have allowed a touchdown to RBs in two straight games and four of their last eight overall. I’ll take Dowdle to find paydirt at this price.

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49ers anytime touchdown pick

George Kittle (+135 at bet365)

George Kittle scored in Week 1 before missing five weeks with an injury, but he hasn’t missed a beat in the last few weeks.

The San Francisco 49ers tight end had two touchdowns last week in Arizona after hauling in nine catches for 84 yards and a score the previous week against the Rams.

He now has five touchdowns in six games this season and has been one of the 49ers’ main targets alongside wide receiver Jauan Jennings.

The Panthers have allowed five touchdowns to tight ends this season, and Kittle is a good bet to make that six.

Odds are correct at the time of publishing and are subject to change.
Not intended for use in MA.
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Ryan Gilbert - Covers
Betting Analyst

Ryan Gilbert brings the passion and pain of being a Philadelphia sports fan. After graduating from Monmouth University with a finance degree, he now uses his statistical background to find inefficiencies in betting markets. With past stops at NHL.com, NBC Sports, and currently at Covers, Ryan's hot picks blend well with the cold ice of a hockey rink.

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