College Football Week 8 Picks: ChatGPT Predicts the Winner of Every Big Game

Louisville vs No. 2 Miami

Moneyline prediction: Miami (-560)
Odds: Miami -13.5; total 51.5.

Miami is a sizable favorite at home with a double-digit spread and a steep moneyline, signaling strong win probability. Louisville has some punch as a big dog (+420), but the market clearly tilts toward the ‘Canes controlling the night. For a straight-up wager, laying the price with Miami is the safer side.

No. 25 Nebraska vs Minnesota

Moneyline prediction: Nebraska (-330)
Odds: Nebraska -8.5; total 46.5.

Nebraska is lined as more than a touchdown favorite at home with a correspondingly short price. Minnesota’s take-back (+265) is tempting for contrarians, but the spread implies a comfortable Cornhuskers edge. I’ll ride the ranking and market respect: Nebraska on the moneyline is the pick.

No. 10 LSU vs No. 17 Vanderbilt

Moneyline prediction: LSU (+110)
Odds: Vanderbilt -2.5; total 48.5.

Vanderbilt’s offense has been one of the SEC’s most efficient to date with 465.6 yards per game (No. 14 nationally) thanks to senior QB Diego Pavia. Explosives and balance have been their calling card. 

LSU’s profile tilts the other way: a stingy defense that’s limited foes to 297.0 yards per game and about 12.2 points per game, while the offense has been more workmanlike (373.5 yards per game). Red-zone TD rate and third-down defense have been LSU strengths as their games have trended lower scoring.

If Vanderbilt protects Pavia and keeps early downs on schedule, the Commodores can leverage chunk plays. LSU’s path is compressing explosives, forcing field goals, and winning the hidden-yardage battle (punts/returns), something their defense/special teams have supported so far. With a tight spread and a live total, single-possession sequencing matters.

In a near coin-flip, I’ll back LSU at +110 to eke out the straight-up result.

No. 12 Georgia Tech vs Duke

Moneyline prediction: Georgia Tech (+102)
Odds: Duke -1.5; total 61.5.

This one’s tight, with Duke a small favorite and Tech a slight plus-money option. Given the AP rank edge and the essentially coin-flip spread, the value case tilts to the Yellow Jackets at plus money. For a straight-up call, I’ll take the modest upset with Georgia Tech.

No. 14 Oklahoma vs South Carolina

Moneyline prediction: Oklahoma (-210)
Odds: Oklahoma -5.5; total 43.5.

The Sooners carry a one-score spread and a moderate moneyline, which implies a solid but not overwhelming edge. South Carolina’s +172 is live, but the market leans OU to handle business. Straight-up, lay the -210 with Oklahoma.

No. 1 Ohio State at Wisconsin

Moneyline prediction: Ohio State (-4500)
Odds: Ohio State -26.5; total 41.5.

Another heavy favorite scenario. The Buckeyes are laying nearly four touchdowns with a corresponding massive moneyline, indicating a very high win probability. Upsets happen, but the market is emphatic. Ohio State is the straight-up choice.

Michigan State at No. 3 Indiana

Moneyline prediction: Indiana (-4500)
Odds: Indiana -27.5; total 52.5.

This is one of the day’s biggest mismatches by the numbers. A four-plus touchdown spread and an enormous moneyline price strongly imply a routine home win. There’s no need to overthink it: Indiana on the moneyline.

No. 4 Texas A&M vs Arkansas

Moneyline prediction: Texas A&M (-315)
Odds: Texas A&M -7.5; total 61.5.

With the Aggies giving more than a touchdown and a fairly short favorite price, the market suggests they’re a tier above here. Arkansas offers +250, but the combination of rank and line strength points to A&M getting it done. I’ll take the Aggies on the moneyline.

No. 5 Mississippi vs No. 9 Georgia 

Moneyline prediction: Georgia (-285)
Odds: Georgia -7.5; total 53.5.

This is a rare Top-10 meeting in a series long controlled by Georgia; the Bulldogs lead 33–14–1 all-time and are 19–4–1 in Athens. The last clash (Nov. 9, 2024) went the other way—Mississippi won 28–10—adding spice to Saturday’s rematch at Sanford Stadium. 

Entering Week 8, Georgia sits 4–1 (2–1 SEC) and Top-10 in the AP poll, while Mississippi comes in unbeaten after surviving Washington State last week to reach 6–0.

The matchup shapes up as Georgia’s physicality and home-field edge versus Mississippi’s explosive offense under Lane Kiffin. The Rebels’ pace and chunk-play ability can stress secondaries, but they’ve shown volatility in game flow (see the narrow WSU escape). Georgia’s profile leans steadier—ball control, field position, and defense that’s typically better on money downs in big spots—plus the series history here favors the Dawgs. 

Mississippi at +230 is frisky, yet the spread says the Bulldogs are more likely to separate late. Straight-up, go for Georgia.

No. 7 Texas Tech vs Arizona State

Moneyline prediction: Texas Tech (-315)
Odds: Texas Tech -8.5; total 51.5.

Lined just under double digits, the Red Raiders’ price mirrors a strong but not runaway edge. The +250 on ASU is notable, yet the spread implies Tech should finish the job more often than not. For a straight-up bet, Texas Tech is the side.

No. 22 Memphis vs UAB

Moneyline prediction: Memphis (-1800)
Odds: Memphis -21.5; total 64.5.

A three-score spread and short favorite price signal controlled dominance expectations. UAB’s +920 is long for a reason. If you’re just picking winners, Memphis is the logical call at a steep number (parlays may be the practical path given the juice).

Oregon vs Rutgers

Moneyline prediction: Oregon (-800)
Odds: Oregon -17.5; total 60.5.

FanDuel’s board paints a clear picture. At -800, Oregon’s implied win probability is about 88.9%, while Rutgers at +550 is roughly 15.4%. The spread/total combo implies a projection near Oregon 39, Rutgers 22. That script expects Oregon to stack 5–6 scoring drives and create separation, with Rutgers needing sustained, clock-chewing offense and a plus turnover margin to stay live.

A -17.5 favorite paired with a 60.5 total also signals pace and explosive-play potential, factors that increase backdoor-cover risk late but rarely flip the outright winner. With the market decisively behind the higher-ceiling side and a three-score expectation, the straight-up pick is the chalk: Oregon to win.

No. 21 Texas vs Kentucky

Moneyline prediction: Texas (-550)
Odds: Texas -12.5; total 42.5.

Texas is laying close to two touchdowns with a moneyline that fits a strong favorite profile. Kentucky at +400 is sizable, but the spread suggests the Longhorns’ defense can grind this down and their offense can stay ahead.

Washington State vs No. 18 Virginia

Moneyline prediction: Virginia (-880)
Odds: Virginia -17.5; total 56.5.

The Cavaliers are big home favorites. With nearly three possessions on the spread and a heavy moneyline, FanDuel’s market expects Virginia to control this game. Washington State’s +580 gives underdog appeal, but straight-up I’ll follow the chalk and back Virginia.

No. 11 Tennessee vs No. 6 Alabama

Moneyline prediction: Alabama (-310)
Odds: Alabama -7.5; total 58.5.

The Tide are a one-score favorite with a moderate favorite price. Tennessee’s +245 is live if this turns into a shootout, but the number indicates Alabama’s edge in key moments. For a moneyline call, lay it with Bama.

No. 20 USC vs No. 13 Notre Dame

Moneyline prediction: Notre Dame (-345)
Odds: Notre Dame -9.5; total 61.5.

The Jeweled Shillelagh rivalry returns to South Bend with Notre Dame leading the all-time series 52–38–5 and riding a two-game streak. USC enters the week 5–1 after a 31–13 win over Michigan, while Notre Dame is 4–2 heading into Week 8. 

The matchup frames USC’s big-play offense and recent momentum against Notre Dame’s steadier, more balanced profile at home. Defensively, both teams have been mid-pack by yardage allowed so far (Notre Dame and USC sitting in the 40s nationally), which puts a premium on situational football—third downs, red zone, and explosives.  

If USC protects the quarterback and turns chunk gains into touchdowns as it did vs. Michigan, the Trojans can tilt it. If Notre Dame limits explosives and leans on a cleaner, methodical script in front of its crowd, the Irish’s consistency becomes the edge.

The -345 price reflects solid confidence in the Irish at home. Straight-up, Notre Dame is the pick.

Florida Atlantic vs No. 19 South Florida

Moneyline prediction: South Florida (-2300)
Odds: South Florida -21.5; total 73.5.

USF is a massive favorite with a very high total, pointing to a game where the Bulls’ offense is expected to roll. FAU’s +1060 is the lottery ticket, but the market is clear. Straight-up, the pick is South Florida.

No. 16 Missouri vs Auburn

Moneyline prediction: Missouri (-122)
Odds: Missouri -1.5; total 43.5.

A true toss-up by spread with Mizzou a small road favorite and a near-pick’em moneyline. When the book hangs -1.5, it’s essentially asking you to choose the winner. I’ll side with the ranked team at the short price: Missouri to win.

No. 23 Utah vs No. 15 BYU

Moneyline prediction: Utah (-162)
Odds: Utah -3.5; total 48.5.

The tightest ranked rivalry line of the night: Utah a field-goal-plus favorite on the road with a manageable moneyline. BYU +134 is attractive in a lower-total setting, but the market still leans Utes to edge it. Straight-up, go for Utah.

No. 24 Cincinnati vs Oklahoma State 

Moneyline prediction: Cincinnati (-2100)
Odds: Cincinnati -21.5; total 57.5.

Cincinnati is laying three touchdowns and priced like a heavy favorite to take care of business. Oklahoma State’s +1000 is a long shot based on the number. If you’re playing it straight up, the Bearcats are the clear selection.