College Football Week 7 Picks: ChatGPT Predicts the Winner of Every Big Game

No. 24 South Florida vs North Texas

Moneyline prediction: South Florida (-116)
Odds: USF -1.5 (-110); Total 68.5.

South Florida’s balanced attack has helped them crack the Top 25, and the Bulls enter Denton as a slight favorite. North Texas can score in bunches, but its defense has been porous against quality opponents.

USF’s passing efficiency and red-zone finishing give it the edge. Expect a high-scoring affair, but talent and consistency lean toward the visitors.

No. 1 Ohio State vs No. 17 Illinois

Moneyline prediction: Ohio State (-690)
Odds: Ohio State -14.5 (−108); Total 49.5.

The Buckeyes have steamrolled opponents behind an elite defense and steady quarterback play. Illinois has improved under its current staff, but it remains outgunned in the trenches.

Unless Ohio State’s offense stalls on the road, this should be controlled from start to finish. Illinois may keep it respectable early, but Ohio State wins comfortably to stay unbeaten.

No. 8 Alabama vs No. 14 Missouri

Moneyline prediction: Alabama (-156)
Odds: Alabama -3.5 (-104); Total 52.5.

This SEC showdown features two ranked powers trending in opposite directions. Alabama’s defense has stabilized after early hiccups, while Missouri relies heavily on quarterback efficiency and tempo.

Expect a physical chess match featuring Bama’s defensive line against Missouri’s quick-strike offense. With experience in big moments, Alabama grinds out a narrow win in Columbia.

Pittsburgh vs No. 25 Florida State

Moneyline prediction: Florida State (−385)
Odds: FSU −10.5 (−108); Total 57.5.

Florida State’s explosive passing attack has shown signs of revival after an inconsistent start. Pittsburgh, meanwhile, has struggled to generate offense and protect its quarterback.

At home, FSU’s playmakers should exploit Pitt’s secondary. The Seminoles’ superior speed and home-field advantage make them the clear moneyline choice. 

Washington State vs No. 4 Mississippi

Moneyline prediction: Mississippi (-10000)
Odds: Mississippi -33.5 (-105); Total 58.5.

Lane Kiffin’s Rebels enter Week 7 as massive favorites, and rightfully so. Washington State’s offense can occasionally surprise, but its defense ranks among the nation’s worst against balanced attacks.

Mississippi cruises at home in a no-brainer straight-up pick.

No. 7 Indiana vs No. 3 Oregon

Moneyline prediction: Oregon (-315)
Odds: Oregon -7.5 (-110); Total 55.5.

Oregon’s high-tempo attack underpins a legitimate playoff push. Indiana’s surprising surge into the Top 10 has been built on disciplined defense and clutch offense, but Autzen Stadium is unforgiving.

The Ducks' speed on the perimeter should stretch Indiana thin. Expect a few early defensive stops before Oregon’s depth wears them down.

No. 6 Oklahoma vs Texas

Moneyline prediction: Texas (-113)
Odds: Texas -1.5 (-105); Total 43.5.

The Red River Rivalry delivers another toss-up. Oklahoma’s offense has been efficient and turnover-averse, while Texas boasts one of the nation’s deepest defensive fronts.

Neutral-site chaos is always part of the script, but Texas’s balance and physicality may prevail this time. The Longhorns’ strength on both sides gives them the narrow edge.

Virginia Tech vs No. 13 Georgia Tech

Moneyline prediction: Georgia Tech (-630)
Odds: GT -14.5 (-110); Total 54.5.

Georgia Tech has quietly pieced together one of the ACC’s most complete squads. Their offense is humming, and the defense continues to improve against the run.

Virginia Tech can keep games close early, but it lacks the firepower to sustain drives. Playing in Atlanta, the Yellow Jackets should roll. 

NC State vs No. 16 Notre Dame

Moneyline prediction: Notre Dame (-2300)
Odds: Notre Dame -22.5 (-110); Total 60.5.

Notre Dame’s offense has rediscovered rhythm thanks to improved line play and a deeper receiving corps. NC State faces a tall order slowing them in South Bend.

While the Wolfpack defense is disciplined, it lacks the playmakers to threaten Notre Dame for four quarters. Expect the Irish to dictate tempo and pull away late. 

No. 22 Iowa State vs Colorado

Moneyline prediction: Iowa State (-150)
Odds: ISU -3.5 (+100); Total 52.5.

The Cyclones have re-established defensive toughness and are quietly climbing the rankings. Colorado’s offense flashes excitement but still struggles against disciplined defenses.

Iowa State’s ground game and special teams give it a steadier profile. Boulder’s altitude could test depth, but overall quality leans toward the Cyclones.

Arkansas vs No. 12 Tennessee

Moneyline prediction: Tennessee (-450)
Odds: Tennessee -12.5 (-110); Total 68.5.

Tennessee’s offensive tempo continues to be one of the nation’s fastest. Arkansas brings physicality but lacks secondary depth to contain the Vols’ vertical passing game.

Neyland Stadium will be rocking, and Tennessee’s defense should generate just enough pressure. Pick Tennessee to win outright, though the total may soar past 68.

Florida vs No. 5 Texas A&M

Moneyline prediction: Texas A&M (-275)
Odds: A&M -7.5 (-102); Total 47.5.

Texas A&M’s defense ranks among the best in the SEC, and Kyle Field gives them a major edge. Florida’s young offense is improving, but the Gators’ line has struggled against elite fronts.

Expect A&M to control the clock and lean on its running game. Aggies take it straight up with disciplined, physical football.

Kansas vs No. 9 Texas Tech

Moneyline prediction: Texas Tech (-650)
Odds: Tech -14.5 (-110); Total 59.5.

Texas Tech remains a Big 12 dark horse. Kansas has shown resilience but is overmatched athletically, especially on defense.

Expect Tech to air it out early and use tempo to build separation. At home, they should handle business comfortably.

No. 10 Georgia vs Auburn

Moneyline prediction: Georgia (-172)
Odds: Georgia -3.5 (-110); Total 45.5.

This SEC classic often defies logic, but Georgia’s defense remains the most reliable unit on the field.

Auburn’s improved offense will test the Bulldogs early, yet Georgia’s poise and efficiency under pressure make the difference. Expect a low-scoring, grind-it-out contest.

No. 15 Michigan vs USC

Moneyline prediction: USC (-134)
Odds: USC -2.5 (-114); Total 57.5.

A clash of blue-blood programs in Los Angeles. Michigan’s physical run game meets USC’s explosive passing attack. If the Trojans’ line can protect long enough, their playmakers will find space.

Michigan’s defense can limit big plays, but cross-country travel and speed mismatches tilt this one westward.

South Carolina vs No. 11 LSU

Moneyline prediction: LSU (-330)
Odds: LSU -8.5 (-110); Total 44.5.

LSU’s defense has stiffened since early-season struggles, and Death Valley at night remains daunting. South Carolina has battled injuries and inconsistency under center.

LSU’s offensive versatility — particularly in the red zone — should prove too much. Pick LSU straight up, with the Under in play given both defenses.

No. 18 BYU vs Arizona

Moneyline prediction: BYU (-126)
Odds: BYU -1.5 (-115); Total 48.5.

A sneaky-good late-night matchup. BYU’s defense travels well, and Arizona’s offense has been inconsistent.

Expect a physical game decided by turnovers and field position. BYU’s balanced approach and veteran leadership give it the edge in Tucson.

No. 21 Arizona State at Utah

Moneyline prediction: Utah (-205)
Odds: Utah -5.5 (-110); Total 48.5.

Utah’s defensive front remains one of the toughest in the Pac-12. Arizona State’s offense has spark, but consistency remains elusive.

Expect Utah to dominate time of possession and lean on its physical rushing attack. Rice-Eccles Stadium is a fortress, and Utah takes care of business.