No. 9 Ole Miss visits Vanderbilt today at FirstBank Stadium in Nashville in Week 6. Kickoff is scheduled for 3:30 p.m. ET on ESPN. The Rebels have a 76% win probability as the 9.5-point favorite.
My Ole Miss vs. Vanderbilt prediction and Week 6 college football picks have the Commodores keeping this SEC battle competitive in a low-scoring affair. For the full slate, see our Week 6 Top 25 predictions and best bets.
Ole Miss is a 9.5-point favorite today, with the total currently at 55.5 and potentially on the move due to Hurricane Isaias.
TOP PICK
Who will win Ole Miss vs Vanderbilt today? Pick: Vanderbilt +9.5
Playable to 52%.
The strength of the Ole Miss offense is undeniably its passing attack, led by Trinidad Chambliss, which could prove problematic against a fundamentally sound Vanderbilt secondary.
Vanderbilt held Auburn quarterback Byrum Brown to a season-low 140 passing yards one week after he threw for 271 yards and three touchdowns against Florida. In Week 5, Vanderbilt gave Georgia its toughest test to date in 2026, trailing by only one score midway through the third quarter before the Bulldogs finally pulled away.
Ole Miss running backs had only 84 rushing yards against Florida and 63 rushing yards against LSU. If the Rebels can't establish their ground attack in rainy conditions today, it's difficult to see them covering a large number. Our Week 6 college football AI predictions agree, projecting a 29-28 Vanderbilt win.
COVERS INTEL: Vanderbilt's pass defense ranks 43rd nationally in PFF grading. Slowing down Trinidad Chambliss through the air is Vanderbilt's key to victory today.
Ole Miss vs Vanderbilt Over/Under pick: Under 55.5
Playable to 55%.
Today's game between Ole Miss and Vanderbilt is forecast to be directly in the path of Hurricane Isaias. Sustained winds above 20 mph, coupled with even stronger gusts, figure to make passing the ball downfield a significant challenge for both offenses. Check our college football weather page for the latest forecast.
A high chance of rain only further increases the likelihood that we see plenty of rushing attempts and a running clock between these teams in Week 6.
Ole Miss vs Vanderbilt combo
Playable to 30%.
In poor weather conditions, taking the underdog to cover in a low-scoring game is a correlated strategy. The strength of Vanderbilt's roster is its veteran defense, which has performed well against other top offenses early in 2026.
Ole Miss vs Vanderbilt combo
- Vanderbilt +9.5
- Under 55.5
Ole Miss vs Vanderbilt prop: Ole Miss team total Under 34.5
Playable to 60%.
Vanderbilt returned seven of its top 10 tacklers from the 2025 campaign, and the results have been evident early this fall.
Auburn scored 39 points and produced 373 yards of total offense against Florida but managed only 21 points and 279 yards of total offense a week later against Vanderbilt.
Georgia had scored at least 41 points in each of its first four games this season but finished Week 5 against Vanderbilt with a season-low 38 points — 17 of which came off turnovers or missed field goals.
Vanderbilt plays good, fundamental defense, rarely missing tackles or suffering major communication breakdowns after the snap. It's difficult to see Ole Miss flirting with 40 points this weekend, especially with poor weather forecast around kickoff.
Ole Miss vs Vanderbilt market trends
Here is how trusted traders are dealing on today's Ole Miss vs. Vanderbilt matchup. Use the widget below to help inform your Ole Miss vs. Vanderbilt prediction.
More Week 6 college football picks
- Today's top college football picks: Saturday, Oct. 10
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- College football underdog picks and upset predictions: Week 6
- College football AI predictions Week 6: ATS and Over/Under picks for every game
- College football Week 6 picks against the spread
- Our favorite college football combos for Week 6
- College football Top 25 predictions and best bets: Week 6
- Our favorite Group of 6 predictions: Week 6
- College football player props: Week 6
- Top picks: 5-2, +2.59 units
- Combos: 4-5, +2.53 units
Ole Miss vs Vanderbilt odds today
For help understanding probabilities, see our odds calculator.
- Spread: Ole Miss -9.5 | Vanderbilt +9.5
- Over/Under: Over 55.5 (48%) | Under 55.5 (53%)
- Moneyline: Ole Miss 77% | Vanderbilt 24%
For the full slate of Week 6 college football matchups, check out our Week 6 college football odds board!
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Ole Miss vs Vanderbilt weather
Today's game between Ole Miss and Vanderbilt is one of several college football matchups directly in the path of Hurricane Isaias. Sustained winds above 20 mph and rain are likely to have a significant impact on this game.
Check out our college football weather page for up-to-date info on every matchup.
Ole Miss vs Vanderbilt trend to know
Vanderbilt has covered the spread in nine of its last 12 games (+5.70 units, 43% ROI). Find more college football betting trends for Ole Miss vs. Vanderbilt.
How to watch Ole Miss vs Vanderbilt
| Location | FirstBank Stadium, Nashville, Tenn. |
| Date | Saturday, Oct. 10, 2026 |
| Kickoff | 3:30 p.m. ET |
| TV | ESPN |
Ole Miss vs Vanderbilt latest injuries
Check out our college football injuries page for updates on every team.
Odds are correct at the time of publishing and are subject to change.
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